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A Questionnaire-Based Study on Use of Plants in Diabetic Patients

Year 2025, Volume: 15 Issue: 1, 63 - 68, 28.03.2025
https://doi.org/10.33808/clinexphealthsci.1431781

Abstract

Objective: Among patients diagnosed with diabetes mellitus, we aimed to investigate the rates of use of medicinal plants, detailed information on use and purchase, socio-demographic characteristics associated with the tendency to use plants, and the status of reporting to health care professionals.
Methods: The study was conducted in family health centers where patients diagnosed with diabetes mellitus visited. A questionnaire form of objective questions was filled for patients. The questionnaire included socio-demographic characteristics (age, gender, education) of the patients, disease condition, medicines used, and whether or not they used plants. If so, more information was obtained on the plants that are the name, used part, preparation method, frequency of administration, the place from which the plants was obtained, the person who advised the product, the knowledge of the physician and his/her attitude about herbals.
Results: 100 people (66% women, 34% men) participated in the study between the ages of 24-80, 13% of them have Type 1 and 87% have Type 2 diabetes. Only 11% of patients use plants. Eight plants have been identified. The most commonly used plant (36.36%) is cinnamon. Among the usage of the plants, decoction is placed on the top, with 78%. 62.5% of the patients obtain the plants from herbal shops. Friends or relatives are the primary sources of information regarding medicinal plant use (73%).
Conclusion: By increasing the knowledge of physicians about plants, it has been seen that patients can share their usage of plants more easily with physicians.

Ethical Statement

This study was approved by Ethics Committee of İstanbul University İstanbul Faculty of Medicine Clinical Research Ethics Committee (09.12.2016/21)

Supporting Institution

The authors received no financial support for the research.

Thanks

We thank all the patients who participated in this survey and shared valuable information.

References

  • WHO. Global report on diabetes. World Health Organization, 2016.
  • IDF. IDF Diabetes Atlas 10th edition. International Diabetes Federation. Brussels, Belgium, 2021. https://www.diabetesatlas.org
  • WHO. Traditional medicine. Fifty-Sixth World Health Assembly, A56/18, 14.10, 31 March 2003.
  • WHO. Noncommunicable Diseases. World Health Organization 2018. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
  • Çakmak S, Nural N. Complementary and alternative medicine applications in chronic diseases. J Intern Med Nurs-Special Topics 2017;3(2):57-64.
  • Ernst E, Fugh-Berman A. Complementary and alternative medicine: What is it all about? Occup Environ Med. 2002;59(2):140-144.
  • Parildar H, Serter R, Yesilada E. Diabetes mellitus and phytotherapy in Turkey. J Pak Med Assoc. 2011;61(11): 1116.
  • Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995;2(2):137-189. https://doi.org/10.1016/S09447113(11)80059-0
  • Governa P, Baini G, Borgonetti V, Cettolin G, Giachetti D, Magnano AR, Miraldi E, Biagi M. Phytotherapy in the management of diabetes: A review. Molecules 2018;23(1):105. https://doi.org/10.3390/molecules23010105
  • Aslan M, Orhan N. Diyabet tedavisinde kullanılan bitkisel ürünler ve gıda destekleri. MİSED 2010;23-24:27-38.
  • Özkum D, Akı Ö, Toklu HZ. Herbal medicine use among diabetes mellitus patients in Northern Cyprus. J Med Plant Res. 2013;7(22):1652-1664. https://doi.org/10.5897/JMPR12.1207
  • Öztürk S, Gündoğdu YP, Gürsu M, Yamak M, Özkan O, Şar F, Yenigün M, Kazancıoğlu R. Use of herbal products in type 2 diabetic patients. Medical Bulletin of Haseki. 2015;53(3):214-219.
  • Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177. https://doi.org/10.3389/fphar.2013.00177
  • Ceylan S, Azal O, Taşlipinar A, Türker T, Açikel CH, Gulec M. Complementary and alternative medicine use among Turkish diabetes patients. Complement Ther Med. 2009;17:78-83. https://doi.org/10.1016/j.ctim.2008.07.003
  • Soner BC, Sahin AS, Sahin TK. A survey of Turkish hospital patients’ use of herbal medicine. Eur J Integr Med. 2013;5(6):547-552. https://doi.org/10.1016/j.eujim.2013.08.004
  • Ali BAM, Mahfouz MS. Herbal medicine use among patients with type 2 diabetes in North Sudan. Annu Res Rev Biol 2014;4(11):1827-1838.
  • Ali-Shtayeh MS, Jamous RM, Jamous RM. Complementary and alternative medicine use amongst Palestinian diabetic patients. Complement Ther Clin Pract. 2012;18(1):16-21. https://doi.org/10.1016/j.ctcp.2011.09.001
  • Mahabir D, Gulliford MC. Use of medicinal plants for diabetes in Trinidad and Tobago. Rev Panam Salud Publ. 1997;1(3):174-179.
  • Al-Asadi JN, Salih N. Herbal remedies use among diabetic patients in Nassyria, Iraq. Middle East J Fam Med. 2012;10(10):40-46.
  • Alami Z, Aynaou H, Alami B, Hdidou Y, Latrech H. Herbal medicines use among diabetic patients in Oriental Morocco. J Pharmacogn Phytotherapy 2015;7(2):9. https://doi.org/10.5897/JPP2014.0338
  • Wazaify M, Afifi FU, El-Khateeb M, Ajlouni K. Complementary and alternative medicine use among Jordanian patients with diabetes. Complement Ther Clinl Pract. 2011;17(2): 71-75. https://doi.org/10.1016/j.ctcp.2011.02.002
  • Dixit S, Tiwari S. Investigation of anti-diabetic plants used among the ethnic communities of Kanpur division, India. J Ethnopharmacol. 2020;253:112639. https://doi.org/10.1016/j.jep.2020.112639
  • Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal. 1999;19(5):757-762. https://doi.org/10.1016/S0731-7085(98)00300-8
  • Nickavar B, Mojab F, Javidnia K, Amoli MAR. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch C. 2003;58(9-10):629-631. https://doi.org/10.1515/znc-2003-9-1004
  • Benhaddou-Andaloussi A, Martineau LC, Spoor D, Vuong T, Leduc C, Joly E, Burt A, Meddah B, Settaf A, Arnason JT, Prentki M, Haddad PS. Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic β-cells, skeletal muscle cells, and adipocytes. Pharm Biol. 2008;46(1-2):96-104. https://doi.org/10.1080/13880200701734810
  • Mathura ML, Gaura J, Sharmaa R, Haldiya KR. Antidiabetic properties of a spice plant Nigella sativa. J Endocrinol Metab. 2011;1(1):1-8. https://doi.org/10.4021/jem12e
  • Shinjyo N, Waddell G, Green J. A tale of two cinnamons: A comparative review of the clinical evidence of Cinnamomum verum and C. cassia as diabetes interventions. J Herb Med. 2020;21:100342. https://doi.org/10.1016/j.hermed.2020.100342
  • Zaidi SF, Aziz M, Muhammad JS, Kadowaki M. Diverse pharmacological properties of Cinnamomum cassia: A review. Pak J Pharm Sci. 2015;28(4):1433-1438.
  • Kumar K, Issac A, Ninan E, Kuttan R, Maliakel B. Enhanced anti-diabetic activity of polyphenol-rich de-coumarinated extracts of Cinnamomum cassia. J Funct Foods. 2014;10:54-64. https://doi.org/10.1016/j.jff.2014.05.008
  • Verspohl EJ, Bauer K, Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother Res. 2005;19(3):203-206. https://doi.org/10.1002/ptr.1643
  • Al-Baidhani R, Rezadoost H, Hamidi A, Motevali SM, Mirzajani F. The α-amylase and α-glucosidase inhibitory effects of some traditional antidiabetic prescriptions based on bioautography using LC-ESI/MSMS. J Medicinal Plants. 2020;21(81): 33-50. https://doi.org/10.52547/jmp.21.81.33
  • Eidi A, Eidi M, Darzi R. Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytother Res. 2009;23(3): 347-350. https://doi.org/10.1002/ptr.2629
  • Guex CG, Reginato FZ, de Jesus PR, Brondani JC, Lopes GHH, de Freitas Bauermann L. Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin. J Ethnopharmacol. 2019;235:1-7. https://doi.org/10.1016/j.jep.2019.02.001
  • Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, Li Y. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-γ and identification of an active component. Toxicol Appl Pharmacol. 2005;207(2):160-169. https://doi.org/10.1016/j.taap.2004.12.009
  • Bagri P, Ali M, Aeri V, Bhowmik M, Sultana S. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 2009;47(1):50-54. https://doi.org/10.1016/j.fct.2008.09.058
Year 2025, Volume: 15 Issue: 1, 63 - 68, 28.03.2025
https://doi.org/10.33808/clinexphealthsci.1431781

Abstract

References

  • WHO. Global report on diabetes. World Health Organization, 2016.
  • IDF. IDF Diabetes Atlas 10th edition. International Diabetes Federation. Brussels, Belgium, 2021. https://www.diabetesatlas.org
  • WHO. Traditional medicine. Fifty-Sixth World Health Assembly, A56/18, 14.10, 31 March 2003.
  • WHO. Noncommunicable Diseases. World Health Organization 2018. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
  • Çakmak S, Nural N. Complementary and alternative medicine applications in chronic diseases. J Intern Med Nurs-Special Topics 2017;3(2):57-64.
  • Ernst E, Fugh-Berman A. Complementary and alternative medicine: What is it all about? Occup Environ Med. 2002;59(2):140-144.
  • Parildar H, Serter R, Yesilada E. Diabetes mellitus and phytotherapy in Turkey. J Pak Med Assoc. 2011;61(11): 1116.
  • Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995;2(2):137-189. https://doi.org/10.1016/S09447113(11)80059-0
  • Governa P, Baini G, Borgonetti V, Cettolin G, Giachetti D, Magnano AR, Miraldi E, Biagi M. Phytotherapy in the management of diabetes: A review. Molecules 2018;23(1):105. https://doi.org/10.3390/molecules23010105
  • Aslan M, Orhan N. Diyabet tedavisinde kullanılan bitkisel ürünler ve gıda destekleri. MİSED 2010;23-24:27-38.
  • Özkum D, Akı Ö, Toklu HZ. Herbal medicine use among diabetes mellitus patients in Northern Cyprus. J Med Plant Res. 2013;7(22):1652-1664. https://doi.org/10.5897/JMPR12.1207
  • Öztürk S, Gündoğdu YP, Gürsu M, Yamak M, Özkan O, Şar F, Yenigün M, Kazancıoğlu R. Use of herbal products in type 2 diabetic patients. Medical Bulletin of Haseki. 2015;53(3):214-219.
  • Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177. https://doi.org/10.3389/fphar.2013.00177
  • Ceylan S, Azal O, Taşlipinar A, Türker T, Açikel CH, Gulec M. Complementary and alternative medicine use among Turkish diabetes patients. Complement Ther Med. 2009;17:78-83. https://doi.org/10.1016/j.ctim.2008.07.003
  • Soner BC, Sahin AS, Sahin TK. A survey of Turkish hospital patients’ use of herbal medicine. Eur J Integr Med. 2013;5(6):547-552. https://doi.org/10.1016/j.eujim.2013.08.004
  • Ali BAM, Mahfouz MS. Herbal medicine use among patients with type 2 diabetes in North Sudan. Annu Res Rev Biol 2014;4(11):1827-1838.
  • Ali-Shtayeh MS, Jamous RM, Jamous RM. Complementary and alternative medicine use amongst Palestinian diabetic patients. Complement Ther Clin Pract. 2012;18(1):16-21. https://doi.org/10.1016/j.ctcp.2011.09.001
  • Mahabir D, Gulliford MC. Use of medicinal plants for diabetes in Trinidad and Tobago. Rev Panam Salud Publ. 1997;1(3):174-179.
  • Al-Asadi JN, Salih N. Herbal remedies use among diabetic patients in Nassyria, Iraq. Middle East J Fam Med. 2012;10(10):40-46.
  • Alami Z, Aynaou H, Alami B, Hdidou Y, Latrech H. Herbal medicines use among diabetic patients in Oriental Morocco. J Pharmacogn Phytotherapy 2015;7(2):9. https://doi.org/10.5897/JPP2014.0338
  • Wazaify M, Afifi FU, El-Khateeb M, Ajlouni K. Complementary and alternative medicine use among Jordanian patients with diabetes. Complement Ther Clinl Pract. 2011;17(2): 71-75. https://doi.org/10.1016/j.ctcp.2011.02.002
  • Dixit S, Tiwari S. Investigation of anti-diabetic plants used among the ethnic communities of Kanpur division, India. J Ethnopharmacol. 2020;253:112639. https://doi.org/10.1016/j.jep.2020.112639
  • Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal. 1999;19(5):757-762. https://doi.org/10.1016/S0731-7085(98)00300-8
  • Nickavar B, Mojab F, Javidnia K, Amoli MAR. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch C. 2003;58(9-10):629-631. https://doi.org/10.1515/znc-2003-9-1004
  • Benhaddou-Andaloussi A, Martineau LC, Spoor D, Vuong T, Leduc C, Joly E, Burt A, Meddah B, Settaf A, Arnason JT, Prentki M, Haddad PS. Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic β-cells, skeletal muscle cells, and adipocytes. Pharm Biol. 2008;46(1-2):96-104. https://doi.org/10.1080/13880200701734810
  • Mathura ML, Gaura J, Sharmaa R, Haldiya KR. Antidiabetic properties of a spice plant Nigella sativa. J Endocrinol Metab. 2011;1(1):1-8. https://doi.org/10.4021/jem12e
  • Shinjyo N, Waddell G, Green J. A tale of two cinnamons: A comparative review of the clinical evidence of Cinnamomum verum and C. cassia as diabetes interventions. J Herb Med. 2020;21:100342. https://doi.org/10.1016/j.hermed.2020.100342
  • Zaidi SF, Aziz M, Muhammad JS, Kadowaki M. Diverse pharmacological properties of Cinnamomum cassia: A review. Pak J Pharm Sci. 2015;28(4):1433-1438.
  • Kumar K, Issac A, Ninan E, Kuttan R, Maliakel B. Enhanced anti-diabetic activity of polyphenol-rich de-coumarinated extracts of Cinnamomum cassia. J Funct Foods. 2014;10:54-64. https://doi.org/10.1016/j.jff.2014.05.008
  • Verspohl EJ, Bauer K, Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother Res. 2005;19(3):203-206. https://doi.org/10.1002/ptr.1643
  • Al-Baidhani R, Rezadoost H, Hamidi A, Motevali SM, Mirzajani F. The α-amylase and α-glucosidase inhibitory effects of some traditional antidiabetic prescriptions based on bioautography using LC-ESI/MSMS. J Medicinal Plants. 2020;21(81): 33-50. https://doi.org/10.52547/jmp.21.81.33
  • Eidi A, Eidi M, Darzi R. Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytother Res. 2009;23(3): 347-350. https://doi.org/10.1002/ptr.2629
  • Guex CG, Reginato FZ, de Jesus PR, Brondani JC, Lopes GHH, de Freitas Bauermann L. Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin. J Ethnopharmacol. 2019;235:1-7. https://doi.org/10.1016/j.jep.2019.02.001
  • Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, Li Y. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-γ and identification of an active component. Toxicol Appl Pharmacol. 2005;207(2):160-169. https://doi.org/10.1016/j.taap.2004.12.009
  • Bagri P, Ali M, Aeri V, Bhowmik M, Sultana S. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 2009;47(1):50-54. https://doi.org/10.1016/j.fct.2008.09.058
There are 35 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Botany
Journal Section Articles
Authors

Bahar Gurdal 0000-0003-4009-100X

Behiye Toprak 0009-0000-5937-243X

Early Pub Date March 23, 2025
Publication Date March 28, 2025
Submission Date February 5, 2024
Acceptance Date March 5, 2025
Published in Issue Year 2025 Volume: 15 Issue: 1

Cite

APA Gurdal, B., & Toprak, B. (2025). A Questionnaire-Based Study on Use of Plants in Diabetic Patients. Clinical and Experimental Health Sciences, 15(1), 63-68. https://doi.org/10.33808/clinexphealthsci.1431781
AMA Gurdal B, Toprak B. A Questionnaire-Based Study on Use of Plants in Diabetic Patients. Clinical and Experimental Health Sciences. March 2025;15(1):63-68. doi:10.33808/clinexphealthsci.1431781
Chicago Gurdal, Bahar, and Behiye Toprak. “A Questionnaire-Based Study on Use of Plants in Diabetic Patients”. Clinical and Experimental Health Sciences 15, no. 1 (March 2025): 63-68. https://doi.org/10.33808/clinexphealthsci.1431781.
EndNote Gurdal B, Toprak B (March 1, 2025) A Questionnaire-Based Study on Use of Plants in Diabetic Patients. Clinical and Experimental Health Sciences 15 1 63–68.
IEEE B. Gurdal and B. Toprak, “A Questionnaire-Based Study on Use of Plants in Diabetic Patients”, Clinical and Experimental Health Sciences, vol. 15, no. 1, pp. 63–68, 2025, doi: 10.33808/clinexphealthsci.1431781.
ISNAD Gurdal, Bahar - Toprak, Behiye. “A Questionnaire-Based Study on Use of Plants in Diabetic Patients”. Clinical and Experimental Health Sciences 15/1 (March 2025), 63-68. https://doi.org/10.33808/clinexphealthsci.1431781.
JAMA Gurdal B, Toprak B. A Questionnaire-Based Study on Use of Plants in Diabetic Patients. Clinical and Experimental Health Sciences. 2025;15:63–68.
MLA Gurdal, Bahar and Behiye Toprak. “A Questionnaire-Based Study on Use of Plants in Diabetic Patients”. Clinical and Experimental Health Sciences, vol. 15, no. 1, 2025, pp. 63-68, doi:10.33808/clinexphealthsci.1431781.
Vancouver Gurdal B, Toprak B. A Questionnaire-Based Study on Use of Plants in Diabetic Patients. Clinical and Experimental Health Sciences. 2025;15(1):63-8.

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