Research Article
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Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus

Year 2025, Volume: 15 Issue: 1, 76 - 82, 28.03.2025
https://doi.org/10.33808/clinexphealthsci.1442009

Abstract

Objective: Diabetes Mellitus is one of the most common diseases which affects life quality. The aim of the study was to examine sleep quality and sleeping related factors in patients with Type 2 Diabetes Mellitus (T2DM).
Methods: An observational, cross-sectional study was conducted between 01.09.2018-01.12.2018 in Sisli Hamidiye Etfal Research and Training Hospital. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Moreover, we used Patient Health Questionaire-9 (PHQ-9) scale to diagnose depression degree.
Results: The study included 227 individuals with T2DM, with a mean age of 60.26 ± 9.13 years, 59.5% of whom were female. The mean disease duration was 10.46 ± 7.65 years, and 70% had accompanying hypertension. Poor sleep quality (PSQI ≥ 6) was identified in 54.2% of participants, with significantly poorer sleep quality observed in females, obese individuals, unemployed participants, and those with diabetes-related complications such as neuropathy and retinopathy (p < .05). Although no significant correlation was found between PSQI and glycemic control markers (HbA1c or fasting blood glucose), participants with higher levels of these markers tended to report poorer sleep. Depression severity (PHQ-9) was strongly associated with poor sleep quality (p < .001), with higher scores observed in females, low-income and unemployed participants, obese individuals, and those with diabetes-related complications.
Conclusion: This study underscores the high prevalence of sleep disturbances among individuals with T2DM, with factors such as female gender, obesity, unemployment, hypertension, and diabetes-related complications like neuropathy and retinopathy significantly impairing sleep quality. The bidirectional relationship between poor sleep and depression highlights the need for integrated mental health support in diabetes care. Although no significant correlations were found between sleep quality and glycemic markers, trends suggest a potential link, warranting further research.

Ethical Statement

This study was approved by Ethics Board of Sisli Hamidiye Etfal Health Application and Research Center (HARC) (Approval date: 07.08.2018; Number: 2064)

References

  • American Diabetes Association. 6. Glycemic Targets: Standards of Medical Care in Diabetes—2020. Diabetes Care 2020; 43 (Supp. 1): S66–S76. https://doi.org/10.2337/dc20-S006
  • Yılmaz MB, Kılıçkap M, Abacı A, Barçın C, Bayram F, Karaaslan D, Göksülük H, Kayıkçıoğlu M, Özer N, Süleymanlar G, Şahin M, Tokgözoğlu L, Satman İ. Temporal changes in the epidemiology of diabetes mellitus in Turkey: A systematic review and meta-analysis. Archives of the Turkish Society of Cardiology 2018; 46(7):546-555. https://doi.org/10.5543/tkda.2018.88225
  • Garg P, Duggal N. Type 2 diabetes mellitus, its impact on quality of life and how the disease can be managed-a review. Obesity Medicine. 2022; 35: 100459 https://doi.org/10.1016/j.obmed.2022.100459
  • Gebremariam GT, Biratu S, Alemayehu M, Welie AG, Beyene K, Sander B, Gebretekle GB. Health related quality of life of patients with type 2 diabetes mellitus at a tertiary care hospital in Ethiopia. PLoS ONE 2022; 17(2): e0264199. https://doi.org/10.1371/journal.pone.0264199
  • Plantinga L, Rao MN, Schillinger D. Prevalence of self-reported sleep problems among people with diabetes in the United States, 2005-2008. Preventing Chronic Disease 2012;9: E76. https://doi.org/10.5888/pcd9.110244
  • Khandelwal D, Dutta D, Chittawar S, Kalra S. Sleep disorders in type 2 diabetes. Indian Journal of Endocrinology and Metabolism 2017;21(5): 758-761. https://doi.org/10.4103/ijem.IJEM_156_17
  • World Health Organization. Regional Office for Europe. (‎2004)‎. WHO technical meeting on sleep and health: Bonn Germany, 22–24 January 2004. World Health Organization. Regional Office for Europe. Available from: https://apps.who.int/iris/handle/10665/349782
  • Crivello A, Barsocchi P, Girolami M, Palumbo F. The meaning of sleep quality: A survey of available technologies. IEEE Access. 2019;(7):167374–167390. https://doi.org/10.1109/ACCESS.2019.2953835
  • Choi D, Kim BY, Jung CH, Kim CH, Mok JO. Association between sleep quality and painless diabetic peripheral neuropathy assessed by current perception threshold in type 2 diabetes mellitus. Diabetes Metab J. 2021 May;45(3):358-367. https://doi.org/10.4093/dmj.2019.0219
  • Reutrakul S, Van Cauter E. Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes. Metabolism. 2018 Jul;84:56-66. https://doi.org/10.1016/j.metabol.2018.02.010
  • Anothaisintawee T, Reutrakul S, Van Cauter E, Thakkinstian A. Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis. Sleep Medicine Reviews. 2016;30:11-24. https://doi.org/10.1016/j.smrv.2015.10.002
  • Knutson KL, Ryden AM, Mander BA, Van Cauter E. Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Archives of Internal Medicine. 2006;166(16):1768-74. https://doi.org/10.1001/archinte.166.16.1768
  • Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2 nd ed. Lawrence Erlbaum Associates.1988.
  • American Diabetes Association. 6. Glycemic Targets: Standards of Medical Care in Diabetes—2020. Diabetes Care 2020; 43 (Supp. 1): S66-S76. https://doi.org/10.2337/dc20-S006
  • Agargün MY, Kara H, Anlar Ö. Pittsburgh Uyku Kalitesi İndeksi’nin geçerliği ve güvenirliği. Türk Psikiyatri Dergisi 1996; 7(2): 107–115.
  • Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine. 2001;16(9):606-13. https://doi.org/10.1046/j.1525-1497.2001.016009606.x.
  • Sari YE, Kokoglu B, Balcioglu H, Bilge U, Colak E, Unluoglu I. Turkish reliability of the Patient Health Questionnaire-9. Biomedical Research. 2016 Special Issue 460-462.
  • Solińska M, Śliwińska A, Kosmalski M, Drzewoski J. The phenotype of elderly patients with type 2 diabetes mellitus and poor sleep quality. International Journal of Environmental Research and Public Health, 2020;17(16): 5992. https://doi.org/10.3390/ijerph17165992
  • Keskin A, Ünalacak M, Bilge U, Yildiz P, Güler S, Burak SE, Muzaffer B. Effects of sleep disorders on hemoglobin a1c levels in type 2 diabetic patients. Chinese Medical Journal, 2015; 128(24): 3292–3297. https://doi.org/10.4103/0366-6999.171415
  • Tsai Y-W, Kann N-H, Tung T-H, Chao Y-J Lin C-J, Chang KC, Chang SS, Chen JY. Impact of subjective sleep quality on glycemic control in type 2 diabetes mellitus. Family Practice, 2012; 29(1):30–35. https://doi.org/10.1093/fampra/cmr041
  • Shamshirgaran SM, Ataei J, Malek A, Iranparvar-Alamdari M, Aminisani N. Quality of sleep and its determinants among people with type 2 diabetes mellitus in Northwest of Iran. World Journal of Diabetes, 2017;8(7):358-364. https://doi.org/10.4239/wjd.v8.i7.358
  • Barakat S, Abujbara M, Banimustafa R, Batieha A, Ajlouni K. Sleep quality in patients with type 2 diabetes mellitus. Journal of Clinical Medicine Research 2019;11(4):261–266. https://doi.org/10.14740/jocmr2947w
  • Cho E-H, Lee H, Ryu OH, Choi MG, Kim S-W. Sleep disturbances and glucoregulation in patients with type 2 diabetes. Jornal of Korean Medical Science 2014; 29(2):243-247. https://doi.org/10.3346/jkms.2014.29.2.243
  • Arslan I. Bilinçli farkındalık, depresyon düzeyleri ve algılanan stres arasındaki ilişki. Birey ve Toplum 2018; 8(2):73–86. https://doi.org/10.20493/birtop.477445
  • Aktaş H, Şaşmaz CT, Kılınçer A, Mert E, Gülbol S, Külekçioğlu D, Kılar S, Yüce R, İbik Y, Uğuz E, Demirtaş A. Yetişkinlerde fiziksel aktivite düzeyi ve uyku kalitesi ile ilişkili faktörlerin araştırılması. Mersin Univ Saglık Bilim Derg. Mart 2016;8(2):60-70.
  • Hung H-C, Yang Y-C, Ou H-Y, Wu J-S, Lu F-H, Chang CJ. The association between self-reported sleep quality and overweight in a Chinese population. Obesity, 2013;21(3):486–492. https://doi.org/10.1002/oby.20259
  • Güzel A. Sleep related hypoventilation and hypoxemia disorders. Güncel Göğüs Hastalıkları Serisi, 2014;2(2):213–224. https://doi.org/10.5152/gghs.2014.0011
  • Spiegel K, Knutson K, Leproult R, Tasali E, Cauter E. Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes. Journal of Applied Physiology 2005;99(5):2008–2019. https://doi.org/10.1152/japplphysiol.00660.2005
  • Van Cauter E, Spiegel K, Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Medicine, 2008;9(1):23–28. https://doi.org/10.1016/S1389-9457(08)70013-3
  • Şahin S, Haliloglu Ö, Korkmaz ÖP, Durcan E, Şahin HR, Yumuk VD, Damcı T, ilkova HM, Siva ZO. Does treatment with sodium-glucose co-transporter-2 inhibitors have an effect on sleep quality, quality of life, and anxiety levels in people with Type 2 diabetes mellitus? Turkish Journal of Medical Sciences, 2012;51(2):735-742. https://doi.org/10.3906/sag-2008-37
  • Rajendran A, Parthsarathy S, Tamilselvan B, Seshadri KG, Shuaib M. Letter: prevalence and correlates of disordered sleep in southeast asian indians with type 2 diabetes. Diabetes & Metabolism Journal 2012;36(4):314-315. https://doi.org/10.4093/dmj.2012.36.1.70
  • Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: Epidemiology, pain description, and quality of life. Diabetes Research and Clinical Practice 2000;47(2):123–128. https://doi.org/10.1016/S0168-8227(99)00112-6
  • Kara AM, Kara T. Relationship of treatment method with medication adherence, quality of life and depression in patients diagnosed with t2dm. The Medical Bulletin of Haseki, 2019; 57(4):377-385. https://doi.org/10.4274/haseki.galenos.2019.4874
  • Ma L, Zhang C. The function and structure of precuneus is associated with subjective sleep quality in major depression. Frontiers in Psychiatry 2021; 12:831524. https://doi.org/10.3389/fpsyt.2021.831524
Year 2025, Volume: 15 Issue: 1, 76 - 82, 28.03.2025
https://doi.org/10.33808/clinexphealthsci.1442009

Abstract

References

  • American Diabetes Association. 6. Glycemic Targets: Standards of Medical Care in Diabetes—2020. Diabetes Care 2020; 43 (Supp. 1): S66–S76. https://doi.org/10.2337/dc20-S006
  • Yılmaz MB, Kılıçkap M, Abacı A, Barçın C, Bayram F, Karaaslan D, Göksülük H, Kayıkçıoğlu M, Özer N, Süleymanlar G, Şahin M, Tokgözoğlu L, Satman İ. Temporal changes in the epidemiology of diabetes mellitus in Turkey: A systematic review and meta-analysis. Archives of the Turkish Society of Cardiology 2018; 46(7):546-555. https://doi.org/10.5543/tkda.2018.88225
  • Garg P, Duggal N. Type 2 diabetes mellitus, its impact on quality of life and how the disease can be managed-a review. Obesity Medicine. 2022; 35: 100459 https://doi.org/10.1016/j.obmed.2022.100459
  • Gebremariam GT, Biratu S, Alemayehu M, Welie AG, Beyene K, Sander B, Gebretekle GB. Health related quality of life of patients with type 2 diabetes mellitus at a tertiary care hospital in Ethiopia. PLoS ONE 2022; 17(2): e0264199. https://doi.org/10.1371/journal.pone.0264199
  • Plantinga L, Rao MN, Schillinger D. Prevalence of self-reported sleep problems among people with diabetes in the United States, 2005-2008. Preventing Chronic Disease 2012;9: E76. https://doi.org/10.5888/pcd9.110244
  • Khandelwal D, Dutta D, Chittawar S, Kalra S. Sleep disorders in type 2 diabetes. Indian Journal of Endocrinology and Metabolism 2017;21(5): 758-761. https://doi.org/10.4103/ijem.IJEM_156_17
  • World Health Organization. Regional Office for Europe. (‎2004)‎. WHO technical meeting on sleep and health: Bonn Germany, 22–24 January 2004. World Health Organization. Regional Office for Europe. Available from: https://apps.who.int/iris/handle/10665/349782
  • Crivello A, Barsocchi P, Girolami M, Palumbo F. The meaning of sleep quality: A survey of available technologies. IEEE Access. 2019;(7):167374–167390. https://doi.org/10.1109/ACCESS.2019.2953835
  • Choi D, Kim BY, Jung CH, Kim CH, Mok JO. Association between sleep quality and painless diabetic peripheral neuropathy assessed by current perception threshold in type 2 diabetes mellitus. Diabetes Metab J. 2021 May;45(3):358-367. https://doi.org/10.4093/dmj.2019.0219
  • Reutrakul S, Van Cauter E. Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes. Metabolism. 2018 Jul;84:56-66. https://doi.org/10.1016/j.metabol.2018.02.010
  • Anothaisintawee T, Reutrakul S, Van Cauter E, Thakkinstian A. Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis. Sleep Medicine Reviews. 2016;30:11-24. https://doi.org/10.1016/j.smrv.2015.10.002
  • Knutson KL, Ryden AM, Mander BA, Van Cauter E. Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Archives of Internal Medicine. 2006;166(16):1768-74. https://doi.org/10.1001/archinte.166.16.1768
  • Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2 nd ed. Lawrence Erlbaum Associates.1988.
  • American Diabetes Association. 6. Glycemic Targets: Standards of Medical Care in Diabetes—2020. Diabetes Care 2020; 43 (Supp. 1): S66-S76. https://doi.org/10.2337/dc20-S006
  • Agargün MY, Kara H, Anlar Ö. Pittsburgh Uyku Kalitesi İndeksi’nin geçerliği ve güvenirliği. Türk Psikiyatri Dergisi 1996; 7(2): 107–115.
  • Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine. 2001;16(9):606-13. https://doi.org/10.1046/j.1525-1497.2001.016009606.x.
  • Sari YE, Kokoglu B, Balcioglu H, Bilge U, Colak E, Unluoglu I. Turkish reliability of the Patient Health Questionnaire-9. Biomedical Research. 2016 Special Issue 460-462.
  • Solińska M, Śliwińska A, Kosmalski M, Drzewoski J. The phenotype of elderly patients with type 2 diabetes mellitus and poor sleep quality. International Journal of Environmental Research and Public Health, 2020;17(16): 5992. https://doi.org/10.3390/ijerph17165992
  • Keskin A, Ünalacak M, Bilge U, Yildiz P, Güler S, Burak SE, Muzaffer B. Effects of sleep disorders on hemoglobin a1c levels in type 2 diabetic patients. Chinese Medical Journal, 2015; 128(24): 3292–3297. https://doi.org/10.4103/0366-6999.171415
  • Tsai Y-W, Kann N-H, Tung T-H, Chao Y-J Lin C-J, Chang KC, Chang SS, Chen JY. Impact of subjective sleep quality on glycemic control in type 2 diabetes mellitus. Family Practice, 2012; 29(1):30–35. https://doi.org/10.1093/fampra/cmr041
  • Shamshirgaran SM, Ataei J, Malek A, Iranparvar-Alamdari M, Aminisani N. Quality of sleep and its determinants among people with type 2 diabetes mellitus in Northwest of Iran. World Journal of Diabetes, 2017;8(7):358-364. https://doi.org/10.4239/wjd.v8.i7.358
  • Barakat S, Abujbara M, Banimustafa R, Batieha A, Ajlouni K. Sleep quality in patients with type 2 diabetes mellitus. Journal of Clinical Medicine Research 2019;11(4):261–266. https://doi.org/10.14740/jocmr2947w
  • Cho E-H, Lee H, Ryu OH, Choi MG, Kim S-W. Sleep disturbances and glucoregulation in patients with type 2 diabetes. Jornal of Korean Medical Science 2014; 29(2):243-247. https://doi.org/10.3346/jkms.2014.29.2.243
  • Arslan I. Bilinçli farkındalık, depresyon düzeyleri ve algılanan stres arasındaki ilişki. Birey ve Toplum 2018; 8(2):73–86. https://doi.org/10.20493/birtop.477445
  • Aktaş H, Şaşmaz CT, Kılınçer A, Mert E, Gülbol S, Külekçioğlu D, Kılar S, Yüce R, İbik Y, Uğuz E, Demirtaş A. Yetişkinlerde fiziksel aktivite düzeyi ve uyku kalitesi ile ilişkili faktörlerin araştırılması. Mersin Univ Saglık Bilim Derg. Mart 2016;8(2):60-70.
  • Hung H-C, Yang Y-C, Ou H-Y, Wu J-S, Lu F-H, Chang CJ. The association between self-reported sleep quality and overweight in a Chinese population. Obesity, 2013;21(3):486–492. https://doi.org/10.1002/oby.20259
  • Güzel A. Sleep related hypoventilation and hypoxemia disorders. Güncel Göğüs Hastalıkları Serisi, 2014;2(2):213–224. https://doi.org/10.5152/gghs.2014.0011
  • Spiegel K, Knutson K, Leproult R, Tasali E, Cauter E. Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes. Journal of Applied Physiology 2005;99(5):2008–2019. https://doi.org/10.1152/japplphysiol.00660.2005
  • Van Cauter E, Spiegel K, Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Medicine, 2008;9(1):23–28. https://doi.org/10.1016/S1389-9457(08)70013-3
  • Şahin S, Haliloglu Ö, Korkmaz ÖP, Durcan E, Şahin HR, Yumuk VD, Damcı T, ilkova HM, Siva ZO. Does treatment with sodium-glucose co-transporter-2 inhibitors have an effect on sleep quality, quality of life, and anxiety levels in people with Type 2 diabetes mellitus? Turkish Journal of Medical Sciences, 2012;51(2):735-742. https://doi.org/10.3906/sag-2008-37
  • Rajendran A, Parthsarathy S, Tamilselvan B, Seshadri KG, Shuaib M. Letter: prevalence and correlates of disordered sleep in southeast asian indians with type 2 diabetes. Diabetes & Metabolism Journal 2012;36(4):314-315. https://doi.org/10.4093/dmj.2012.36.1.70
  • Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: Epidemiology, pain description, and quality of life. Diabetes Research and Clinical Practice 2000;47(2):123–128. https://doi.org/10.1016/S0168-8227(99)00112-6
  • Kara AM, Kara T. Relationship of treatment method with medication adherence, quality of life and depression in patients diagnosed with t2dm. The Medical Bulletin of Haseki, 2019; 57(4):377-385. https://doi.org/10.4274/haseki.galenos.2019.4874
  • Ma L, Zhang C. The function and structure of precuneus is associated with subjective sleep quality in major depression. Frontiers in Psychiatry 2021; 12:831524. https://doi.org/10.3389/fpsyt.2021.831524
There are 34 citations in total.

Details

Primary Language English
Subjects Endocrinology, Family Medicine
Journal Section Articles
Authors

Elif Serap Esen 0000-0002-1303-4360

Güzin Zeren Öztürk 0000-0001-7730-2929

Early Pub Date March 23, 2025
Publication Date March 28, 2025
Submission Date February 27, 2024
Acceptance Date February 26, 2025
Published in Issue Year 2025 Volume: 15 Issue: 1

Cite

APA Esen, E. S., & Zeren Öztürk, G. (2025). Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus. Clinical and Experimental Health Sciences, 15(1), 76-82. https://doi.org/10.33808/clinexphealthsci.1442009
AMA Esen ES, Zeren Öztürk G. Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus. Clinical and Experimental Health Sciences. March 2025;15(1):76-82. doi:10.33808/clinexphealthsci.1442009
Chicago Esen, Elif Serap, and Güzin Zeren Öztürk. “Analysis of Sleep Quality and Related Factors in Patients With Type 2 Diabetes Mellitus”. Clinical and Experimental Health Sciences 15, no. 1 (March 2025): 76-82. https://doi.org/10.33808/clinexphealthsci.1442009.
EndNote Esen ES, Zeren Öztürk G (March 1, 2025) Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus. Clinical and Experimental Health Sciences 15 1 76–82.
IEEE E. S. Esen and G. Zeren Öztürk, “Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus”, Clinical and Experimental Health Sciences, vol. 15, no. 1, pp. 76–82, 2025, doi: 10.33808/clinexphealthsci.1442009.
ISNAD Esen, Elif Serap - Zeren Öztürk, Güzin. “Analysis of Sleep Quality and Related Factors in Patients With Type 2 Diabetes Mellitus”. Clinical and Experimental Health Sciences 15/1 (March 2025), 76-82. https://doi.org/10.33808/clinexphealthsci.1442009.
JAMA Esen ES, Zeren Öztürk G. Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus. Clinical and Experimental Health Sciences. 2025;15:76–82.
MLA Esen, Elif Serap and Güzin Zeren Öztürk. “Analysis of Sleep Quality and Related Factors in Patients With Type 2 Diabetes Mellitus”. Clinical and Experimental Health Sciences, vol. 15, no. 1, 2025, pp. 76-82, doi:10.33808/clinexphealthsci.1442009.
Vancouver Esen ES, Zeren Öztürk G. Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus. Clinical and Experimental Health Sciences. 2025;15(1):76-82.

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