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Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries

Year 2025, Volume: 15 Issue: 1, 132 - 136, 28.03.2025
https://doi.org/10.33808/clinexphealthsci.1485598

Abstract

Objective: Chemical eye injuries are ophthalmic emergencies that require rapid intervention. It can cause extensive damage to the ocular surface and anterior segment leading to severe visual impairment. In this study, we aimed to report the clinical findings and visual outcomes of patients with chemical eye injuries.
Methods: A total of 59 eyes of 50 patients who were followed up and treated with the diagnosis of chemical eye injury in Marmara University Ophthalmology Department between 2013 and 2020 were included in the study. Demographic and clinical data of the patients were analyzed.
Results: Mean age of patients was 31.9±12.5 (1-55 years). The mean follow-up period of the patients was 21.3±40.9 (median: 13; range: 3-310) days. 74.6% of the injuries occurred in the workplace. The exposed agent was acidic in 47.5%, alkaline in 39.0%, and the agent in 13.5% of eyes was unknown. The mean initial and final BCVA were 0.51±0.44 and 0.09±0.42 LogMAR, respectively. The observed improvement in BCVA values was statistically significant (p<.001). According to the Roper-Hall classification, 62.7% (37) of the eyes were grade I, and according to the Dua classification, 54.9% (43) of the eyes were grade I and II. The two classifications were correlated with each other (p<.001). While medical treatment was sufficient in 94.9% of the eyes, additional amniotic membrane transplantation (AMT) was applied in 3 eyes. conjunctival limbal autograft transplantation combined with AMT was performed in a patient with a grade IV chemical eye injury.
Conclusion: Adequate and timely treatment helps to of paramount importance to mitigate complications. Additionally, staging of ocular surface burns is crucial to determine prognosis and management plan. Chemical eye injuries are often associated with occupational accidents; therefore, preventive measures and workers' education are imperative.

References

  • Singh P, Tyagi M, Kumar Y, Gupta K, Sharma P. Ocular chemical injuries and their management. Oman Journal of Ophthalmology 2013;6(2):83. https://doi.org/10.4103/0974-620X.116624
  • Wagoner MD. Chemical injuries of the eye: current concepts in pathophysiology and therapy. Surv Ophthalmol. 1997;41(4):275-313. https://doi.org/10.1016/s0039-6257(96)00007-0
  • Roper-Hall MJ. Thermal and chemical burns. Trans Ophthalmol Soc U K (1962). 1965;85:631-653.
  • Gupta N, Kalaivani M, Tandon R. Comparison of prognostic value of Roper Hall and Dua classification systems in acute ocular burns. Br J Ophthalmol. 2011;95(2):194-198. https://doi.org/10.1136/bjo.2009.173724
  • Dua HS, King AJ, Joseph A. A new classification of ocular surface burns. Br J Ophthalmol. 2001;85(11):1379-1383. https://doi.org/10.1136/bjo.85.11.1379
  • Bizrah M, Yusuf A, Ahmad S. An update on chemical eye burns. Eye (Lond). 2019;33(9):1362-1377. https://doi.org/10.1038/s41433-019-0456-5
  • Ghosh S, Salvador-Culla B, Kotagiri A, Pushpoth S, Tey A, Johnson ZK, Figueiredo FC. Acute chemical eye injury and limbal stem cell deficiency. A prospective study in the United Kingdom. Cornea 2019;38(1):8-12. https://doi.org/10.1097/ICO.0000000000001739
  • Kuckelkorn R, Luft I, Kottek AA, Schrage NF, Makropoulos W, Reim M. Chemical and thermal eye burns in the residential area of RWTH Aachen. Analysis of accidents in 1 year using a new automated documentation of findings. Klin Monbl Augenheilkd. 1993;203(1):34-42. https://doi.org/10.1055/s-2008-1045646
  • Haring RS, Sheffield ID, Channa R, Canner JK, Schneider EB. Epidemiologic trends of chemical ocular burns in the United States. JAMA Ophthalmology 2016;134(10):1119-1124. https://doi.org/10.1001/jamaophthalmol.2016.2645
  • Li T, Jiang B, Zhou X. Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017. Int Ophthalmol. 2020;40(4):909-916. https://doi.org/10.1007/s10792-019-01263-w
  • Dua HS, Ting DSJ, Al Saadi A, Said DG. Chemical eye injury: Pathophysiology, assessment and management. Eye 2020;34(11):2001-2019. https://doi.org/10.1038/s41433-020-1026-6
  • Kuckelkorn R, Kottek A, Schrage N, Reim M. Poor prognosis of severe chemical and thermal eye burns: the need for adequate emergency care and primary prevention. Int Arch Occup Environ. Health 1995;67(4):281-284. https://doi.org/10.1007/BF00409410
  • Salman İA, Gündoğdu C. Epithelial healing in experimental corneal alkali wounds with nondiluted autologous serum eye drops. Cutan Ocul Toxicol. 2010;29(2):116-121. https://doi.org/10.3109/15569521003709558
  • Yin J, Jurkunas U, editors. Limbal stem cell transplantation and complications. Semin Ophthalmol. 2018;33(1):134-141. https://doi.org/10.1080/08820538.2017.1353834
  • Lin MP, Ekşioğlu Ü, Mudumbai RC, Slabaugh MA, Chen PP. Glaucoma in patients with ocular chemical burns. Am J Ophthalmol. 2012;154(3):481-485. https://doi.org/10.1016/j.ajo.2012.03.026
  • Kuckelkorn R, Redbrake C, Reim M. Tenonplasty: A new surgical approach for the treatment of severe eye burns. SLACK Incorporated Thorofare, NJ; 1997. p. 105-110.
  • Dua HS, Miri A, Faraj LA, Said DG. Free autologous conjunctival grafts. Ophthalmology 2012;119(10):2189-e2. https://doi.org/10.1016/j.ophtha.2012.06.004
  • Eslani M, Baradaran-Rafii A, Cheung AY, Kurji KH, Hasani H, Djalilian AR, Holland EJ. Amniotic membrane transplantation in acute severe ocular chemical injury: A randomized clinical trial. Am J Ophthalmol. 2019;199: 209-215. https://doi.org/10.1016/j.ajo.2018.11.001
  • Gupta N, Kalaivani M, Tandon R. Comparison of prognostic value of Roper Hall and Dua classification systems in acute ocular burns. Br J Ophthalmol. 2011;95(2):194-198. https://doi.org/10.1136/bjo.2009.173724
Year 2025, Volume: 15 Issue: 1, 132 - 136, 28.03.2025
https://doi.org/10.33808/clinexphealthsci.1485598

Abstract

References

  • Singh P, Tyagi M, Kumar Y, Gupta K, Sharma P. Ocular chemical injuries and their management. Oman Journal of Ophthalmology 2013;6(2):83. https://doi.org/10.4103/0974-620X.116624
  • Wagoner MD. Chemical injuries of the eye: current concepts in pathophysiology and therapy. Surv Ophthalmol. 1997;41(4):275-313. https://doi.org/10.1016/s0039-6257(96)00007-0
  • Roper-Hall MJ. Thermal and chemical burns. Trans Ophthalmol Soc U K (1962). 1965;85:631-653.
  • Gupta N, Kalaivani M, Tandon R. Comparison of prognostic value of Roper Hall and Dua classification systems in acute ocular burns. Br J Ophthalmol. 2011;95(2):194-198. https://doi.org/10.1136/bjo.2009.173724
  • Dua HS, King AJ, Joseph A. A new classification of ocular surface burns. Br J Ophthalmol. 2001;85(11):1379-1383. https://doi.org/10.1136/bjo.85.11.1379
  • Bizrah M, Yusuf A, Ahmad S. An update on chemical eye burns. Eye (Lond). 2019;33(9):1362-1377. https://doi.org/10.1038/s41433-019-0456-5
  • Ghosh S, Salvador-Culla B, Kotagiri A, Pushpoth S, Tey A, Johnson ZK, Figueiredo FC. Acute chemical eye injury and limbal stem cell deficiency. A prospective study in the United Kingdom. Cornea 2019;38(1):8-12. https://doi.org/10.1097/ICO.0000000000001739
  • Kuckelkorn R, Luft I, Kottek AA, Schrage NF, Makropoulos W, Reim M. Chemical and thermal eye burns in the residential area of RWTH Aachen. Analysis of accidents in 1 year using a new automated documentation of findings. Klin Monbl Augenheilkd. 1993;203(1):34-42. https://doi.org/10.1055/s-2008-1045646
  • Haring RS, Sheffield ID, Channa R, Canner JK, Schneider EB. Epidemiologic trends of chemical ocular burns in the United States. JAMA Ophthalmology 2016;134(10):1119-1124. https://doi.org/10.1001/jamaophthalmol.2016.2645
  • Li T, Jiang B, Zhou X. Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017. Int Ophthalmol. 2020;40(4):909-916. https://doi.org/10.1007/s10792-019-01263-w
  • Dua HS, Ting DSJ, Al Saadi A, Said DG. Chemical eye injury: Pathophysiology, assessment and management. Eye 2020;34(11):2001-2019. https://doi.org/10.1038/s41433-020-1026-6
  • Kuckelkorn R, Kottek A, Schrage N, Reim M. Poor prognosis of severe chemical and thermal eye burns: the need for adequate emergency care and primary prevention. Int Arch Occup Environ. Health 1995;67(4):281-284. https://doi.org/10.1007/BF00409410
  • Salman İA, Gündoğdu C. Epithelial healing in experimental corneal alkali wounds with nondiluted autologous serum eye drops. Cutan Ocul Toxicol. 2010;29(2):116-121. https://doi.org/10.3109/15569521003709558
  • Yin J, Jurkunas U, editors. Limbal stem cell transplantation and complications. Semin Ophthalmol. 2018;33(1):134-141. https://doi.org/10.1080/08820538.2017.1353834
  • Lin MP, Ekşioğlu Ü, Mudumbai RC, Slabaugh MA, Chen PP. Glaucoma in patients with ocular chemical burns. Am J Ophthalmol. 2012;154(3):481-485. https://doi.org/10.1016/j.ajo.2012.03.026
  • Kuckelkorn R, Redbrake C, Reim M. Tenonplasty: A new surgical approach for the treatment of severe eye burns. SLACK Incorporated Thorofare, NJ; 1997. p. 105-110.
  • Dua HS, Miri A, Faraj LA, Said DG. Free autologous conjunctival grafts. Ophthalmology 2012;119(10):2189-e2. https://doi.org/10.1016/j.ophtha.2012.06.004
  • Eslani M, Baradaran-Rafii A, Cheung AY, Kurji KH, Hasani H, Djalilian AR, Holland EJ. Amniotic membrane transplantation in acute severe ocular chemical injury: A randomized clinical trial. Am J Ophthalmol. 2019;199: 209-215. https://doi.org/10.1016/j.ajo.2018.11.001
  • Gupta N, Kalaivani M, Tandon R. Comparison of prognostic value of Roper Hall and Dua classification systems in acute ocular burns. Br J Ophthalmol. 2011;95(2):194-198. https://doi.org/10.1136/bjo.2009.173724
There are 19 citations in total.

Details

Primary Language English
Subjects Ophthalmology
Journal Section Articles
Authors

Esra Biberoğlu Çelik 0000-0002-6137-1070

Semra Akkaya Turhan 0000-0001-8322-1842

Özlem Şahin 0000-0003-2907-2852

Ebru Toker 0000-0002-1352-3025

Early Pub Date March 23, 2025
Publication Date March 28, 2025
Submission Date May 17, 2024
Acceptance Date February 26, 2025
Published in Issue Year 2025 Volume: 15 Issue: 1

Cite

APA Biberoğlu Çelik, E., Akkaya Turhan, S., Şahin, Ö., Toker, E. (2025). Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries. Clinical and Experimental Health Sciences, 15(1), 132-136. https://doi.org/10.33808/clinexphealthsci.1485598
AMA Biberoğlu Çelik E, Akkaya Turhan S, Şahin Ö, Toker E. Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries. Clinical and Experimental Health Sciences. March 2025;15(1):132-136. doi:10.33808/clinexphealthsci.1485598
Chicago Biberoğlu Çelik, Esra, Semra Akkaya Turhan, Özlem Şahin, and Ebru Toker. “Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries”. Clinical and Experimental Health Sciences 15, no. 1 (March 2025): 132-36. https://doi.org/10.33808/clinexphealthsci.1485598.
EndNote Biberoğlu Çelik E, Akkaya Turhan S, Şahin Ö, Toker E (March 1, 2025) Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries. Clinical and Experimental Health Sciences 15 1 132–136.
IEEE E. Biberoğlu Çelik, S. Akkaya Turhan, Ö. Şahin, and E. Toker, “Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries”, Clinical and Experimental Health Sciences, vol. 15, no. 1, pp. 132–136, 2025, doi: 10.33808/clinexphealthsci.1485598.
ISNAD Biberoğlu Çelik, Esra et al. “Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries”. Clinical and Experimental Health Sciences 15/1 (March 2025), 132-136. https://doi.org/10.33808/clinexphealthsci.1485598.
JAMA Biberoğlu Çelik E, Akkaya Turhan S, Şahin Ö, Toker E. Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries. Clinical and Experimental Health Sciences. 2025;15:132–136.
MLA Biberoğlu Çelik, Esra et al. “Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries”. Clinical and Experimental Health Sciences, vol. 15, no. 1, 2025, pp. 132-6, doi:10.33808/clinexphealthsci.1485598.
Vancouver Biberoğlu Çelik E, Akkaya Turhan S, Şahin Ö, Toker E. Evaluation of Clinical Findings and Visual Prognosis in Chemical Eye Injuries. Clinical and Experimental Health Sciences. 2025;15(1):132-6.

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