Deriving Behaviour of Hodgkin Huxley model with fever dynamics: A computational study

Year 2017, Volume: 2 Issue: 2, 47 - 54, 01.06.2017

Hasan Eskalen Sukru Ozgan

https://izlik.org/JA82XY76YH

Abstract

A single neuron can be modeled by the set of differential equations. Hodgkin-Huxley (HH) model, the one of the most
famous neuron model, can be considered as a dynamical system with four independent variables. Here we studied to reduce the number of differential equation required for conductance based HH model under strong inhibitory noise. Exponential Integrate and Fire (EIF) model, one independent variable, is used as a reduced model of HH model by using current-voltage (I-V) curve of the original model.
The required reduction parameters are determined from this curve. The behaviour of HH model and its reduced EIF (rEIF) model are
in good agreement in sub-threshold level. Above-threshold behaviour of reduced EIF model and original model compared in terms of
threshold voltage under strong inhibitory noise. Our numerical simulations clearly show that sub-threshold behaviour of HH model
perfectly reduced to rEIF model

Keywords

Hodgkin-Huxley , exponential integrate and fire , I-V curve , reduction