Research Article

A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation

Volume: 3 Number: 1 April 30, 2018
EN

A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation

Abstract

We present a 2D - mathematical model for tumor angiogenesis and solve it by linearizing it using an initial data perturbation approximation method. This method is a well-known and highly effective method to obtain solutions of coupled non-linear differential equations. This method shows that a few terms of the obtained approximate solution are enough to get an idea about the movement of endothelial, macrophage and pericyte cells in the extra cellular matrix, which are needed for the initiation of tumor angiogenesis.  MATLAB-generated figures are provided.


Keywords

References

  1. [1] Paweletz, N., Knierim, M., Tumor-related angiogenesis, Critical Reviews in Oncology/Hematology, V.9, N.3, 1989, pp.197-242.
  2. [2] Nicosia, R.F., Bonanno, E., Smith, M., Fibronectin promotes the elongation of micro vessels during angiogenesis in vitro, Journal of Cellular Physiology, V.154, N.3, 1993, pp.654-661.
  3. [3] Yamada, K.M., Olden, K., Fibronectins-adhesive glycoproteins of cell surface and blood, Nature, V. 275, N. 5677, 1978, pp. 179-184.
  4. [4] Folkman, J., Tumor angiogenesis: therapeutic implications, New England Journal of Medicine, V.285, N.21, 1971, pp.1182-1186.
  5. [5] Folkman, J., The vascularization of tumors, Scientific American, V.234, N.5, 1976, pp.58-70.
  6. [6] Schleef, R. R., Birdwell, C. R., The effect of proteases on endothelial cell migration in vitro, Experimental Cell Research, V.141, N.2, 1982, pp. 505-508.
  7. [7] Othmer, H. G., Stevens, A., Aggregation, blow up, and collapse: the ABCS of taxis in reinforced random walks, SIAM Journal on Applied Mathematics, V. 57, N. 4, 1997, pp. 1044-1081.

Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

İrem Cay This is me
Türkiye

Publication Date

April 30, 2018

Submission Date

November 15, 2017

Acceptance Date

January 15, 2018

Published in Issue

Year 2018 Volume: 3 Number: 1

APA
Pamuk, S., & Cay, İ. (2018). A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation. Communication in Mathematical Modeling and Applications, 3(1), 13-27. https://izlik.org/JA57PC27SZ
AMA
1.Pamuk S, Cay İ. A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation. CMMA. 2018;3(1):13-27. https://izlik.org/JA57PC27SZ
Chicago
Pamuk, Serdal, and İrem Cay. 2018. “A Mathematical Analysis of a 2D Model for Tumor Angiogenesis: An Initial Data Perturbation Approximation”. Communication in Mathematical Modeling and Applications 3 (1): 13-27. https://izlik.org/JA57PC27SZ.
EndNote
Pamuk S, Cay İ (April 1, 2018) A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation. Communication in Mathematical Modeling and Applications 3 1 13–27.
IEEE
[1]S. Pamuk and İ. Cay, “A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation”, CMMA, vol. 3, no. 1, pp. 13–27, Apr. 2018, [Online]. Available: https://izlik.org/JA57PC27SZ
ISNAD
Pamuk, Serdal - Cay, İrem. “A Mathematical Analysis of a 2D Model for Tumor Angiogenesis: An Initial Data Perturbation Approximation”. Communication in Mathematical Modeling and Applications 3/1 (April 1, 2018): 13-27. https://izlik.org/JA57PC27SZ.
JAMA
1.Pamuk S, Cay İ. A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation. CMMA. 2018;3:13–27.
MLA
Pamuk, Serdal, and İrem Cay. “A Mathematical Analysis of a 2D Model for Tumor Angiogenesis: An Initial Data Perturbation Approximation”. Communication in Mathematical Modeling and Applications, vol. 3, no. 1, Apr. 2018, pp. 13-27, https://izlik.org/JA57PC27SZ.
Vancouver
1.Serdal Pamuk, İrem Cay. A mathematical analysis of a 2D model for tumor angiogenesis: An initial data perturbation approximation. CMMA [Internet]. 2018 Apr. 1;3(1):13-27. Available from: https://izlik.org/JA57PC27SZ