A COMPARATIVE STUDY OF ZERO-ORDER AND DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF RIVASTIGMINE IN SINGLE DOSAGE FORM

In this study zero-order, first and second derivative spectrophotometric methods were applied to the determination of Rivastigmine (RVT) in capsules. UV-spectrum, first derivative and second derivative spectrums of RVT were plotted in the spectral range of 230-280 nm. Zero-order, first derivative and second derivative absorbance values were measured at maximum wavelenghts for this three methods. Lineer calibration graphs were found in the working range of 0.2 mM -1.0 mM (80 - 400 pg ml1). All three methods were statistically compared with each other and significant results were obtained