ASYMMETRIC SYNTHESIS İN A REFORMATZKY REACTION PREPARATION OF OPTICALLY ACTIVE p-HYDROXY ACIDS

Year 1985, Volume: 31 , 0 - 0, 01.01.1985

H. H. Zoorob

https://doi.org/10.1501/Commub_0000000265

Abstract

Reaction of benzaldehyde with optically active bromoacetic ester derivative I in a Refor* matzky reaction gives, after hydrolysis of the resulting ester, laevorotatory B-hydroxy-Bphenyl phenyl-propionic acid. Moreover, reaction of ethyi bromoacetate with acetophenone in the pre¬sence of zinc and 1,2:5,6-di-Odsopropylideno-a-D-glucofuranose (II) is accompanied by partial asymmetric synthesis as is shownby hydrolysis of the resulting ester to laevorotatory B-hydroxy -B-phenylbutyric acid.

Keywords

ASYMMETRIC , REFORMATZKY REACTION , p-HYDROXY ACIDS

References

• Communications Faculty of Sciences University of Ankara Series B Chemistry and Chemical Engineering