Research Article
BibTex RIS Cite
Year 2018, Volume: 27 Issue: 1, 25 - 36, 01.06.2018
https://doi.org/10.1501/commuc_0000000189

Abstract

References

  • C.A. Challener, Overview of chirality. In: Chiral drugs, 1st. Aldershot (England): Ashgate Publisher, 3-14, 2001.
  • D.E. Drayer, The early history of stereochemistry. In: Drug stereochemistry, Analytical methods and pharmacology, I.W. Wainer, editor. New York: Marcel Dekker Publisher. 1-24, (1993).
  • L.A. Nguyen, H. He, and C. Pham-Huy, Chiral drugs: an overview, International Journal of Biomedical Science, 2(2), (2006) 85.
  • H.B. Vickery, Rules for the nomenclature of the natural amino acids and related substances. Journal of Biological Chemistry, 169(2), (1947) 237-245.
  • J.L. Bada, Racemization of amino acids. In: Chemistry and biochemistry of the amino acids, Dordrecht: Springer. 399-414, 1985.
  • B.J. Johnson and G.H. Miller, Archaeological applications of amino acid racemization, Archaeometry. 39(2), (1997) 265-287.
  • A. Julg, Origin of the L-homochirality of amino-acids in the proteins of living organisms. In: Molecules in Physics, Chemistry, and Biology. Dordrecht: Springer. 33-52, 1989.
  • J.L. Bada, Amino acid racemization dating of fossil bones, Annual Review of Earth and Planetary Sciences, 13(1), (1985) 241-268.
  • J. Csapo, Z. S. Kiss-Csapo, C. Albert and K. Lóki, Hydrolysis of proteins performed at high temperatures and for short times with reduced racemization, in order to determine the enantiomers of D-and L-amino acids, Acta Univ. Sapientiae, Alimentaria, 1, (2008) 31-48.
  • K. Alkass, B.A. Buchholz, S. Ohtani, T. Yamamoto, H. Druid and K.L. Spalding, Age estimation in forensic sciences application of combined aspartic acid racemization and radiocarbon analysis, Proteomics.,9(5), (2010) 1022-1030.
  • A. Koçyiğit, Karabük‐Safranbolu Tersiyer havzası kuzey kenarının stratigrafisi ve niteligi, Bull. Geol. Soc. Turk. 30, (1987) 61-69.
  • J. Csapó, C. Albert, K. Lóki and G. Pohn, Age determination based on amino acid racemization: a new possibility, Acta Univ. Sapientiae, 1, (2008) 109-118.
  • J. Blamire, Kjeldahl Method, http://www.brooklyn.cuny.edu/bc/ahp/ SDKC/Chem/SD_KjeldahlMethod.html, (2003) Retrieved 11/04/2018.
  • R.C. Team, R: A language and environment for statistical computing, 2013.

AGE DETERMINATION OF FOSSILS COLLECTED FROM KARABÜK, SAFRANBOLU, BULAK RIVER AREA BY USING AMINO ACID RACEMIZATION METHOD

Year 2018, Volume: 27 Issue: 1, 25 - 36, 01.06.2018
https://doi.org/10.1501/commuc_0000000189

Abstract

Amino acids present in the proteins of living organisms are mostly in L forms at the time they are synthesized. Over a very long period of time after the death of living organisms, due to the effect of high temperature, pressure and other environmental factors a chemical transformation of L form to its enantiomer, D form occurs. This conversion reaction is known as racemization and it continues until D/L ratio is equal to 1. Thus, the age of any death body can be predicted by determining the D/L ratio of amino acids. The aim of this study is to determine the age of fossils collected from Karabük, Safranbolu, Bulak River area by using amino acid racemization method. Five fossil samples were used and D/L alanine ratios in the samples were used to determine their ages. As a result of the study it was observed that the age estimations by amino acid racemization method were quite lower than the age predictions during fossil identification step. The reason of this difference is thought to be related to the lack of data in the literature, which is used in constructing calibration curve

References

  • C.A. Challener, Overview of chirality. In: Chiral drugs, 1st. Aldershot (England): Ashgate Publisher, 3-14, 2001.
  • D.E. Drayer, The early history of stereochemistry. In: Drug stereochemistry, Analytical methods and pharmacology, I.W. Wainer, editor. New York: Marcel Dekker Publisher. 1-24, (1993).
  • L.A. Nguyen, H. He, and C. Pham-Huy, Chiral drugs: an overview, International Journal of Biomedical Science, 2(2), (2006) 85.
  • H.B. Vickery, Rules for the nomenclature of the natural amino acids and related substances. Journal of Biological Chemistry, 169(2), (1947) 237-245.
  • J.L. Bada, Racemization of amino acids. In: Chemistry and biochemistry of the amino acids, Dordrecht: Springer. 399-414, 1985.
  • B.J. Johnson and G.H. Miller, Archaeological applications of amino acid racemization, Archaeometry. 39(2), (1997) 265-287.
  • A. Julg, Origin of the L-homochirality of amino-acids in the proteins of living organisms. In: Molecules in Physics, Chemistry, and Biology. Dordrecht: Springer. 33-52, 1989.
  • J.L. Bada, Amino acid racemization dating of fossil bones, Annual Review of Earth and Planetary Sciences, 13(1), (1985) 241-268.
  • J. Csapo, Z. S. Kiss-Csapo, C. Albert and K. Lóki, Hydrolysis of proteins performed at high temperatures and for short times with reduced racemization, in order to determine the enantiomers of D-and L-amino acids, Acta Univ. Sapientiae, Alimentaria, 1, (2008) 31-48.
  • K. Alkass, B.A. Buchholz, S. Ohtani, T. Yamamoto, H. Druid and K.L. Spalding, Age estimation in forensic sciences application of combined aspartic acid racemization and radiocarbon analysis, Proteomics.,9(5), (2010) 1022-1030.
  • A. Koçyiğit, Karabük‐Safranbolu Tersiyer havzası kuzey kenarının stratigrafisi ve niteligi, Bull. Geol. Soc. Turk. 30, (1987) 61-69.
  • J. Csapó, C. Albert, K. Lóki and G. Pohn, Age determination based on amino acid racemization: a new possibility, Acta Univ. Sapientiae, 1, (2008) 109-118.
  • J. Blamire, Kjeldahl Method, http://www.brooklyn.cuny.edu/bc/ahp/ SDKC/Chem/SD_KjeldahlMethod.html, (2003) Retrieved 11/04/2018.
  • R.C. Team, R: A language and environment for statistical computing, 2013.
There are 14 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Research Articles
Authors

Sibel Kara This is me

Tahir Özdemir This is me

Ergin Murat Altuner This is me

Publication Date June 1, 2018
Published in Issue Year 2018 Volume: 27 Issue: 1

Cite

Communications Faculty of Sciences University of Ankara Series C-Biology.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.