BIOLOGICAL ACTIVITIES OF ADIANTUM CAPILLUS-VENERIS COLLECTED FROM DUHOK PROVINCE (IRAQ)

Year 2019, Volume: 28 Issue: 2, 128 - 142, 15.12.2019

Falah Saleh Mohammed , Mustafa Sevindik , Celal Bal , Hasan Akgül , Zeliha Selamoglu

Abstract

           This study determined the DPPH free-radical scavenging activity, total
antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index
(OSI), DNA-protective activity, antiproliferative activity, antimicrobial
activity and phenolic contents of methanol (MeOH) and dichloromethane (DCM)
extracts of A. capillus-veneris
leaves collected from the province of Duhok (Iraq). As a result of the studies,
it was determined that the MeOH extract of A.
calocephalum had a 49.74% free-radical scavenging activity at 2 mg/mL
concentration. It was found that the extracts were effective against the test
microorganisms at a concentration level of 200-400 µg/mL. TAS, TOS and OSI
values were 3.086±0.066, 21.532±0.525 and 0.698±0.002, respectively. The
DNA-protective activity of the extracts was found to be weak compared to the
positive control. It was found that, depending on the increase in
concentration, the extracts showed antiproliferative activity on A549 cells.
Furthermore, the HPLC analyses found Catechin, Cinnamic acid, Chlorogenic acid,
Caffeic acid, p-Coumaric acid, Rosmarinic acid and 4-Hydroxybenzoic acid with
various ppm values. Consequently, it was determined that A. capillus-veneris could be a potential natural source
pharmacologically.

Keywords

Adiantum capillus-veneris, Antioxidant, Antimicrobial, DNA protective, antiproliferative, Phenolic content

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