Kan akımı kısıtlamalı direnç egzersizlerinin irisine ve cinsiyet hormonlarına akut etkisi

Year 2022, , 122 - 128, 31.12.2022

Sabriye Ercan , Ayhan Canbulut , Fevziye Burcu Şirin , Hülya Mete Arıcan , Ahsen Oğul , Cem Çetin

https://doi.org/10.58208/cphs.1195891

Abstract

Amaç: Egzersiz ile irisin ve seks hormonlarının salınımı arasındaki ilişki netlik kazanmamış, güncel bir araştırma konusu olarak ilgi çekmektedir. Bu çalışmada kan akımı kısıtlamalı direnç egzersizlerinin irisin ve cinsiyet hormonlarına akut etkisinin incelenmesi amaçlanmıştır.
Gereç ve Yöntem: Araştırmaya, yaşı 20-35 yıl arasında olan sağlıklı erkekler (n=17) dahil edilmiştir. Katılımcıların fiziksel aktivite düzeyi Uluslararası Fiziksel Aktivite Anketi-kısa form ile belirlenmiştir. Vücut kompozisyon analizi ve izotonik kas kuvvet ölçümü yapılan bireyler kan akımı kısıtlamalı düşük şiddetli (1-Maksimum Tekrar’ın %20’sinde) direnç egzersizi (n=6), kan akımı kısıtlamasız yüksek şiddetli (1-Maksimum Tekrar’ın %70’inde) direnç egzersizi (n=5) ve kontrol grubu (n=6) olarak 3 gruba ayrılmıştır. Egzersize akut irisin, testosteron ve östrojen yanıtını değerlendirmek için egzersiz sonrası 15. dakika katılımcılardan kan alınmıştır.
Bulgular: Araştırmaya 17 sağlıklı erkek katılmıştır. Katılımcıların yaş ortalaması 26,12±2,89 yıl, fiziksel aktivite düzeyleri 1259,17±1003,12 MET/hafta, 1-Maksimum Tekrarı ise ortalama 41,12±7,48 kg saptanmıştır. Grupların tanımlayıcı özellikleri homojen dağılmıştır (p>0,05). Akut egzersiz sonrasında irisin ve cinsiyet hormon seviyelerinde gruplar arasında istatistiksel olarak anlamlı fark bulunmamaktadır (p>0,05).
Sonuç: Kan akımı kısıtlamalı düşük şiddetli direnç egzersizleri ile kan akımı kısıtlamasız yüksek şiddetli direnç egzersizleri sonrasında salınan irisin ve cinsiyet hormonları düzeyleri arasında fark saptanmamıştır.

Keywords

Kan akımı, egzersiz, testosteron, östrojen, irisin

Project Number

None

Acute effect of blood flow restricted resistance exercise on irisin and sex hormones

Abstract

Purpose: The relationship between exercise and irisin and sex hormone release is unclear and is of interest to current research. This study aimed to investigate the acute effect of blood flow restricted (BFR) resistance exercise on irisin and sex hormones.
Material and Methods: Healthy males (n=17) aged 20-35 years were included in the study. Participants' physical activity levels were determined using International Physical Activity Questionnaire (IPAQ)-short form. Participants underwent body composition analysis and isotonic muscle strength measurement and were randomly divided into 3 groups: low-intensity (20% of 1-RM) BFR resistance exercise (n=6), high-intensity (70% of 1-RM) non-BFR resistance exercise (n=5), and a control group (n=6). Blood samples were obtained 15 minutes post-exercise to assess acute irisin, testosterone, and estrogen responses.
Results: The study included 17 healthy males. The mean age of participants was 26.12±2.89 years, mean physical activity was 1259.17±1003.12 MET/week, and mean 1-RM was 41.12±7.48 kg. The descriptive characteristics of the groups were homogeneously distributed (p>0.05). The acute post-intervention irisin and sex hormone levels were not statistically different between the groups (p>0.05).
Conclusion: There was no difference found between the levels of irisin and sex hormones released after low-intensity BFR resistance exercise and high-intensity non-BFR resistance exercise.

Keywords

Blood flow, exercise, testosterone, estrogens, irisin

Supporting Institution

None

Project Number

None

Thanks

We thank Dr. FHK for his assistance in data collection.

References

• 1. Fatouros IG. Is irisin the new player in exercise-induced adaptations or not? A 2017 update. Clin Chem Lab Med. 2018; 56:525-548.
• 2. Huh JY, Mougios V, Kabasakalis A, Ioannis F, Aikaterina S, Ioannis D, et al. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J Clin Endocrinol Metab. 2014; 99(11): 2154-2161.
• 3. Hughes L, Paton B, Rosenblatt B, Gissane C, Patterson SD. Blood flow restriction training in clinical musculoskeletal rehabilitation: A systematic review and meta-analysis. Br J Sports Med. 2017(13); 51:1003-1011.
• 4. Miller BC, Tirko AW, Shipe JM, Sumeriski OR, Moran K. The systemic effects of blood flow restriction training: a systematic review. IJSPT. 2021;16(4):978-990.
• 5. Loenneke JP, Kim D, Fahs CA, Thiebaud RS, Abe T, Larson RD, et al. Effects of exercise with and without different degrees of blood flow restriction on torque and muscle activation. Muscle Nerve. 2015; 51(5):713-721.
• 6. Tennent DJ, Hylden CM, Johnson AE, Burns CB, Wilken JM, Owens JG. Blood flow restriction training after knee arthroscopy: A randomized controlled pilot study. Clin J Sport Med. 2017;27:245-252.
• 7. Gundermann DM, Walker DK, Reidy PT, Borack MS, Dickinson JM, Volpi E, et al. Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin. Am J Physiol Metab. 2014;306(10): 1198-1204.
• 8. Fox J, Rioux V, Goulet B, Johanssen NM, Swift DL, Bouchard DR, et al. Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: A meta-analysis. Scand J Med Sci Sport. 2018(1);28:16-28.
• 9. Zunner BE, Wachsmuth NB, Eckstein ML, Scherl L, Schierbauer JR, Haupt S, et al. Myokines and Resistance Training: A Narrative Review. Int J Mol Sci. 2022;23(7):3501.
• 10. Bhasin S, Woodhouse L, Storer TW. Proof of the effect of testosterone on skeletal muscle. J Endocrinol. 2001;170(1):27-38.
• 11. Potter NJ, Tomkinson GR, Dufner TJ, Walch TJ, Roemmich JN, Wilson PB, et al. Effects of exercise training on resting testosterone concentrations in insufficiently active men: a systematic review and meta-analysis. J Strength Cond Res. 2021;35(12):3521-3528.
• 12. Kamenov Z, Assyov Y, Angelova P, Gateva A, Tsakova A. Irisin and testosterone in men with metabolic syndrome. Horm Metab Res. 2017;49(10):755-759.
• 13. Ibrahim M, Ahmed S, Abdel Moety D, Elsayed SF. The relation of serum irisin level with metabolic and hormonal changes in rat model of polycystic ovary. Zagazig Univ Med J. 2018;24(5):409-419.
• 14. Mohamadi S, Khoshdel A, Naserkhani F, Mehdizadeh R. The effect of low- intensity resistance training with blood flow restriction on serum cortisol and testosterone levels in young men. J Arch Mil Med. 2015;3(3):e28306.
• 15. Saglam M, Arikan H, Savci S, Ince D, Guclu M, Karabulut E, et al. International physical activity questionnaire: Reliability and validity of the Turkish version. Percept Mot Skills. 2010; 111:278–284.
• 16. Aslan H. Futbolcularda vücut kompozisyonunun incelenmesi. Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Spor Bilimleri ve Teknolojisi Programı, 2014.
• 17. Silva JC, Domingos-Gomes JR, Freitas ED, Neto GR, Aniceto RR, Bemben MG, et al. Physiological and perceptual responses to aerobic exercise with and without blood flow restriction. J Strength Cond Res. 2021;35(9): 2479-2485.
• 18. Reeves G V., Kraemer RR, Hollander DB, Clavier J, Thomas C, Francois M, et al. Comparison of hormone responses following light resistance exercise with partial vascular occlusion and moderately difficult resistance exercise without occlusion. J Appl Physiol. 2006; 101(6):1616–1622.
• 19. Brzycki M. A practical approach to strength training. Grand Rapids MI: Masters Press, Indianapolis,1989.
• 20. Jackson AS, Pollock ML. Practical assessment of body composition. Phys Sportsmed. 1985;13(5):76–90.
• 21. Clarkson MJ, May AK, Warmington SA. Chronic blood flow restriction exercise improves objective physical function: A systematic review. Front Physiol. 2019;10:1058.
• 22. Lauver JD, Cayot TE, Rotarius TR, Scheuermann BW. Acute neuromuscular and microvascular responses to concentric and eccentric exercises with blood flow restriction. J Strength Cond Res. 2020;34(10):2725–2733.
• 23. Korta P, Pocheć E, Mazur-Biały A. Irisin as a multifunctional protein: Implications for health and certain diseases. Medicina (Kaunas). 2019; 55(8):485.
• 24. Kleerekoper M. Hormones. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostic, Five Edition. Saunders; 2017:837–63.
• 25. Tsuchiya Y, Ando D, Takamatsu K, Goto K. Resistance exercise induces a greater irisin response than endurance exercise. Metabolism. 2015; 64(9):1042–1050.
• 26. Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pöllänen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?. J Physiol. 2013; 591(21):5393–5400.
• 27. Kraemer RR, Goldfarb AH, Reeves GV, Meachum WA, Castracane VD. Effects of partial vascular occlusion on irisin responses to loaded muscle contractions. Appl Physiol Nutr Metab. 2016; 41(3):332–334.
• 28. Madarame H, Neya M, Ochi E, Sato Y, Ishii N. Cross-transfer effects of resistance training with blood flow restriction. Med Sci Sports Exerc. 2008; 40(2):258–263.
• 29. Sharifi S, Monazzami A, Nikousefat Z, Heyrani A, Yari K. The acute and chronic effects of resistance training with blood flow restriction on hormonal responses in untrained young men: A comparison of frequency. Cell Mol Biol (Noisy-le-grand). 2020;66(1):1–8.
• 30. Fekri-Kurabbaslou V, Shams S, Amani-Shalamzari S. Effect of different recovery modes during resistance training with blood flow restriction on hormonal levels and performance in young men: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2022;14(1):47.
• 31. Loenneke JP, Wilson JM, Pujol TJ, Bemben MG. Acute and chronic testosterone response to blood flow restricted exercise. Horm Metab Res.2011;43(10):669–673.
• 32. Singhal V, Lawson EA, Ackerman KE, Fazeli PK, Clarke H, Lee H, et al. Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates. PLoS One. 2014;9(6):e100218.
• 33. Gao S, Cheng Y, Zhao L, Chen Y, Liu Y. The relationships of irisin with bone mineral density and body composition in PCOS patients. Diabetes Metab Res Rev. 2016; 32(4):421–428.