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Resveratrolün Kronik Hastalıklar Üzerindeki Etkileri

Year 2024, , 6 - 14, 30.04.2024
https://doi.org/10.58208/cphs.1345889

Abstract

Resveratrol, vücutta çeşitli terapötik faydaları bulunan bir nutrasötiktir. Çok sayıda bitkide bulunduğu bilinmektedir. Özellikle üzüm, dut, çilek ve yer fıstığı gibi besinlerde farklı konsantrasyonlarda olduğu görülmüştür. Resveratrol bitkilerin ultraviyole, yaralanma ve mantar gibi durumlara maruz kalması sonucu, sentezlenen ikincil metabolittir. Resveratrol üzerine yapılan araştırmaların sonucunda; immun sistemi düzenlediği, kronik hastalıklara karşı fayda sağladığı gözlenmiştir. Kardiyovasküler hastalıklar ve nörodejeneratif hastalıklarda vücudu oksijen stresine karşı koruduğu, oksidatif stres oluşumunu engellediği, inflamasyon oluşumunu ve gelişimini engellediği gözlenmiştir. Resveratrol alımının, glikoz metabolizması ve yağ metabolizması üzerinde etkili olduğu gözlenmiştir. Bu nedenle obezite gelişimine karşı vücutta etkili olabileceği düşünülmektedir. Resveratrolün hücresel süreçlerde rol oynayan apoptoz, mitokondriyal biyogenez, anti-oksidan sistem ve enzimler, glikoz ve lipit metabolizması ve inflamatuvar sitokinler üzerine de etkileri bulunmaktadır. Bunların yanında anti-tümör özellik gösterdiği, kan şekerini regüle ettiği, kalp ve sinir hücrelerini koruduğu, anti-adipojenik faaliyet gösterdiği yapılan araştırmalarda gözlenmiştir. Metabolik sendromla ilişkili glikoz ve lipit metabolizması, kan basıncı, yağ kütlesi, inflamasyon ve oksidatif stresin resveratrol alımıyla regüle edildiği yapılan deneylerde elde edilmiştir. Bu derlemede, resveratrolün sağlık üzerine potansiyel etki mekanizmaları ile kronik hastalıkların önlenmesi ve tedavisindeki rolü üzerine yapılan araştırmaların değerlendirilmesi amaçlanmıştır.

References

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  • Ronis MJJ, Pedersen KB, Watt J. Adverse effects of nutraceuticals and dietary supplements. Annu Rev Pharmacol Toxicol. 2018;58:583-601.
  • Karaman S, Özcan T. Fonksiyonel Süt ürünlerinin geliştirilmesinde nutrasötik bileşenler. Gıda ve Yem Bilimi Teknolojisi Dergisi. 2018;20:30-45.
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  • Ronis MJJ, Pedersen KB, Watt J. Adverse effects of nutraceuticals and dietary supplements. Annu Rev Pharmacol Toxicol. 2018;58:583-601.
  • Yang AJT, Bagit A, MacPherson REK. Resveratrol, metabolic dysregulation, and Alzheimer’s disease: Considerations for neurogenerative disease. Int J Mol Sci. 2021;22(9):4628.
  • Tain YL, Hsu CN. Developmental programming of the metabolic syndrome: Can we reprogram with resveratrol?. Int J Mol Sci. 2018;19(9):2584.
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The Effects of Resveratrol in Chronic Diseases

Year 2024, , 6 - 14, 30.04.2024
https://doi.org/10.58208/cphs.1345889

Abstract

Resveratrol is a nutraceutical with various therapeutic benefits in the body. It is known to be found
in many plants. It is found in different concentrations in plants such as grape, mulberry, strawberry
and peanut etc. It is a secondary metabolite synthesized by exposure of plants to conditions such as
ultraviolet, injury and fungi in order to synthesize resveratrol. A lot of research made on resveratrol
has shown that it regulates the immune system and provides benefits against chronic diseases.
It has also shown that it protects the body against oxidative stress in cardiovascular diseases and
neurodegenerative diseases, thus preventing the formation of oxidative stress and preventing the
formation and development of inflammation. Furthermore resveratrol intake has an effect on glucose
metabolism and fat metabolism. Thus, it is thought that it can form a defense against the development
of obesity. Resveratrol also has effects on apoptosis, mitochondrial biogenesis, anti-oxidant system
and enzymes, glucose and lipid metabolism, and inflammatory cytokines that play a role in cellular
processes. In addition, it has been observed that it has anti-tumor properties, regulates blood sugar,
protects heart and nerve cells, and has anti-adiggienic activity. According to information obtained in
experiments, glucose and lipid metabolism, blood pressure, fat mass, inflammation and oxidative stress
associated with metabolic syndrome are regulated by resveratrol intake. To conclude, in this rewiev,
it was aimed to evaluate the studies on potential effects of resveratrol on health and its role in the
prevention and treatment of chronic diseases.

References

  • Aronson JK. Defining 'nutraceuticals': Neither nutritious nor pharmaceutical. Br J Clin Pharmacol. 2017;83(1):8-19.
  • Ronis MJJ, Pedersen KB, Watt J. Adverse effects of nutraceuticals and dietary supplements. Annu Rev Pharmacol Toxicol. 2018;58:583-601.
  • Karaman S, Özcan T. Fonksiyonel Süt ürünlerinin geliştirilmesinde nutrasötik bileşenler. Gıda ve Yem Bilimi Teknolojisi Dergisi. 2018;20:30-45.
  • Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, et al. Potential adverse effects of resveratrol: A literature review. Int J Mol Sci. 2020;21(6):2084.
  • Pannu N, Bhatnagar A. Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases. Biomed Pharmacother. 2019;109:2237-2251.
  • Ronis MJJ, Pedersen KB, Watt J. Adverse effects of nutraceuticals and dietary supplements. Annu Rev Pharmacol Toxicol. 2018;58:583-601.
  • Yang AJT, Bagit A, MacPherson REK. Resveratrol, metabolic dysregulation, and Alzheimer’s disease: Considerations for neurogenerative disease. Int J Mol Sci. 2021;22(9):4628.
  • Tain YL, Hsu CN. Developmental programming of the metabolic syndrome: Can we reprogram with resveratrol?. Int J Mol Sci. 2018;19(9):2584.
  • Zhang LX, Li CX, Kakar MU, Khan MS, Wu PF, Amir RM, et al. Resveratrol (RV): A pharmacological review and call for further research. Biomed Pharmacother. 2021;143:112164.
  • Barber TM, Kabisch S, Randeva HS, Pfeiffer AFH, Weickert MO. Implications of resveratrol in obesity and ınsulin resistance: A State-of-the-Art review. Nutrients. 2022;14(14):2870.
  • Chaplin A, Carpéné C, Mercader J. Resveratrol, metabolic syndrome, and gut microbiota. Nutrients. 2018;10(11):1651.
  • Hu Y, Chen D, Zheng P, Yu J, He J, Mao X, et al. The bidirectional interactions between resveratrol and gut microbiota: An insight into oxidative stress and inflammatory bowel disease therapy. Biomed Res Int. 2019; 2019: 5403761.
  • Berman AY, Motechin RA, Wiesenfeld MY, Holz MK. The therapeutic potential of resveratrol: A review of clinical trials. NPJ Precision Oncology. 2017;1(1): 1-9.
  • Biesinger S, Michaels HA, Quadros AS, Qian Y, Rabovsky AB, Badger RS, et al. A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects. Eur J Clin Nutr. 2016;70(1):10-16.
  • Göçmen AY, Burgucu D, Gümüşlü S. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target. Appl Physiol Nutr Metab. 2011;36(3):323-330.
  • Lin YC, Chen LH, Varadharajan T, Tsai MJ, Chia YC, Yuan TC, et al. Resveratrol inhibits glucose-induced migration of vascular smooth muscle cells mediated by focal adhesion kinase. Mol Nutr Food Res. 2014;58(7):1389-1401.
  • Bonnefont-Rousselot D. Resveratrol and cardiovascular diseases. Nutrients. 2016; 8(5):250.
  • Breuss JM, Atanasov AG, Uhrin P. Resveratrol and its effects on the vascular system. Int J Mol Sci. 2019;20(7):1523.
  • Dolinsky VW, Chakrabarti S, Pereira TJ, Oka T, Levasseur J, Beker D, et al. Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochim Biophys Acta. 2013;1832(10):1723-1733.
  • Dyck GJB, Raj P, Zieroth S, Dyck JRB, Ezekowitz JA. The effects of resveratrol in patients with cardiovascular disease and heart failure: A narrative review. Int J Mol Sci. 2019;20(4):904.
  • Sung MM, Das SK, Levasseur J, Byrne NJ, Fung D, Kim TT, et al. Resveratrol treatment of mice with pressure-overload-induced heart failure improves diastolic function and cardiac energy metabolism. Circ Heart Fail. 2015;8(1):128-137.
  • Kung HC, Lin KJ, Kung CT, Lin TK. Oxidative stress, mitochondrial dysfunction, and neuroprotection of polyphenols with respect to resveratrol in Parkinson’s disease. Biomedicines. 2021;9(8):918.
  • Brites D, Fernandes A. Neuroinflammation and depression: Microglia activation, extracellular microvesicles and microRNA dysregulation. Front Cell Neurosci. 2015;9:476.
  • Zortea K, Franco VC, Francesconi LP, Cereser KM, Lobato MI, Belmonte-de-Abreu PS. Resveratrol supplementation in schizophrenia patients: A randomized clinical trial evaluating serum glucose and cardiovascular risk factors. Nutrients. 2016;8(2):73.
  • Alayev A, Berger SM, Holz MK. Resveratrol as a novel treatment for diseases with mTOR pathway hyperactivation. Ann N Y Acad Sci. 2015;1348(1):116-123.
  • McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Yang LV, Murata RM, et al. Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging (Albany NY). 2017;9(6):1477-1536.
  • Majumdar AP, Banerjee S, Nautiyal J, Patel BB, Patel V, Du J, et al. Curcumin synergizes with resveratrol to inhibit colon cancer. Nutr Cancer. 2009;61(4):544-553.
  • Carter LG, D'Orazio JA, Pearson KJ. Resveratrol and cancer: Focus on in vivo evidence. Endocr Relat Cancer. 2014;21(3):R209-R225.
  • Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, et al. The role of resveratrol in cancer therapy. J Mol Sci. 2017;18(12):2589.
  • Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis. Mol Nutr Food Res. 2015;59(1):147-159.
  • Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res. 2012;32(7):537-541.
  • Thazhath SS, Wu T, Bound MJ, Checklin HL, Standfield S, Jones KL, et al. Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: A randomized controlled trial. Am J Clin Nutr. 2016;103(1):66-70.
  • Novelle MG, Wahl D, Diéguez C, Bernier M, de Cabo R. Resveratrol supplementation: Where are we now and where should we go?. Ageing Res Rev. 2015;21:1-15.
  • Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, et al. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab. 2013;18(4):533-545.
  • Konings E, Timmers S, Boekschoten MV, Goossens GH, Jocken JW, Afman LA, et al. The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. Int J Obes (Lond). 2014;38(3):470-473.
  • Springer M, Moco S. Resveratrol and ıts human metabolites-effects on metabolic health and obesity. Nutrients. 2019;11(1):143.
  • Szkudelska K, Nogowski L, Szkudelski T. Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes. J Steroid Biochem Mol Biol. 2009;113(1-2):17-24.
  • Gomez-Zorita S, Tréguer K, Mercader J, Carpéné C. Resveratrol directly affects in vitro lipolysis and glucose transport in human fat cells. J Physiol Biochem. 2013;69(3):585-593.
  • Zhao Y, Chen B, Shen J, Wan L, Zhu Y, Yi T, et al. The beneficial effects of quercetin, curcumin, and resveratrol in obesity. Oxid Med Cell Longev. 2017;2017:1459497.
  • Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, et al. Novel insights of dietary polyphenols and obesity. J Nutr Biochem. 2014;25(1):1-18.
  • Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127(6):1109-1122.
  • Szkudelska K, Szkudelski T. Resveratrol, obesity and diabetes. Eur J Pharmacol. 2010;635(1-3):1-8.
  • Heebøll S, Kreuzfeldt M, Hamilton-Dutoit S, Kjær PM, Stødkilde-Jørgensen H, Møller HJ, et al. Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease. Scand J Gastroenterol. 2016;51(4):456-464.
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There are 65 citations in total.

Details

Primary Language Turkish
Subjects Clinical Nutrition
Journal Section Reviews
Authors

Betül Tuba Başkurt 0009-0002-4915-402X

Solmaz Ece Yılmaz 0000-0002-7133-7079

Publication Date April 30, 2024
Published in Issue Year 2024

Cite

Vancouver Başkurt BT, Yılmaz SE. Resveratrolün Kronik Hastalıklar Üzerindeki Etkileri. SBGY. 2024;5(1):6-14.