Ürolitin-A’nın Non-Enfeksiyöz İshalli Buzağılarda Dışkı Skorları Üzerine Etkinliğinin Araştırılması

Year 2025, Volume: 6 Issue: 1, 39 - 46, 30.04.2025

Deniz Alıç Ural , Kerem Ural , Serdar Paşa , Mehmet Gültekin , Hasan Erdoğan , Songül Erdoğan , Cansu Balıkçı , Ayşe İdil Kizilkanat

https://doi.org/10.58208/cphs.1607670

Abstract

Amaç: Bu araştırmada amaç, fonksiyonel gıda özelliğine sahip olan Ürolithin-a' (Ür-a)’nın enfeksiyöz
olmayan ishalli buzağılarda doğal tedavi katılımcısı olarak etki edip edemeyeceğini multidisipliner
olarak tespit etmektir. Gereç ve Yöntem: Bu amaçla 1 ila 28 günlük ishalli neonatal buzağılar
arasından seçilerek, non-enfeksiyöz etiyolojiye sahip olan 40 buzağı çalışmaya dahil edildi. Enfeksiyöz
ve enfeksiyöz olmayan ishaller arasında ayırıcı tanı için mikrobiyolojik, parazitolojik ve virolojik
laboratuvar testlerine dayalı bir algoritma kullanıldı. Dışkı puanlaması 0 (normal kıvam) ile 3 (sıvı
form) arasında bir ölçekle yapıldı. Ür-a, herhangi bir yan etki olmaksızın 10 ardışık gün boyunca 50
mg/kg dozunda oral yoldan uygulandı. Bulgular: Ür-a uygulamasına ilişkin olarak dışkı skorları
(ortalama±standart sapma) önceki başlangıç değerleri olan 1.826 ± 0.242'ye (p < 0,01) kıyasla 0'a düştü.
Sonuç: Elde edilen veriler, bu ön sonuçların non-infeksiyöz ishalli buzağılarda Ür-a'nın gastrointestinal
sağlığı destekleyici etkinliğine sahip olabileceğini gösterebilir. İleriki çalışmaların gerçekleştirilmesi
gerekliliği, bir sonraki çalışmamızın amacı olacaktır

Keywords

Buzağı , ishal , non-enfeksiyöz , urolithin-a

Investigation Of The Effectiveness Of Urolithin-A On Fecal Scores In Calves With Non-İnfectious Diarrhea

Abstract

Aim: The aim of this study was to determine multidisciplinary whether Urolithin-a (Ur-a), which has
functional food properties, can be effective as a natural treatment agent in calves with non-infectious
diarrhea. Materials and Methods: For this purpose, neonatal calves with diarrhea aged 1 to 28 days
and 40 calves selected with non-infectious etiology were included in the study. An algorithm based on
microbiological, parasitological and virological laboratory tests was used for differential diagnosis
between infectious and non-infectious diarrhea. Stool scoring was done on a scale from 0 (normal
consistency) to 3 (liquid form). Ur-a was administered orally at a dose of 50 mg/kg for 10 consecutive
days without any side effects. Results: With regard to Ur-a administration, fecal scores (mean±standard
deviation) decreased to 0 compared to the previous baseline values of 1.826 ± 0.242 (p < 0.01).
Conclusion: The obtained data may indicate that these preliminary results may have the efficacy of
Ur-a in supporting gastrointestinal health in calves with non-infectious diarrhea. The need for further
studies will be the aim of our next study.

Keywords

Calf , diarrhea , non-infectious , Urolithin-a

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