Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Göknil Coşkun; Akın Aklamuz; Ufuk İnce; Mert Ülgen

doi:10.17776/csj.1105811

EN

Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Abstract

Bacterial infection today occupies a tremendous place in world health. The infection diseases were kept under control after the development of penicillin and further studies were performed on the development of new antibacterial agents. However, to date, bacterial resistance caused a big failure in the treatment of infectious disease and therefore, development of new antibacterial agents became important for human health. In the present study, we have designed, synthesized and elucidated the structures of new hydrazide-hydrazone compounds and their hybrid amide derivatives. The structures of the compounds were elucidated with spectroscopic methods and their purity were proven by TLC, HPLC-MS analysis. The antibacterial and antifungal activity studies of the novel molecules were investigated on different strains. Among the synthesized compounds, AA3a and AA4a appeared to show promising antibacterial activity. None of the compounds showed significant antifungal activity on Candida albicans. The drug likeness properties and boiled-egg plot analysis were performed for all of the compounds. The novel molecules showed no violation on Lipinski’s rule of five and all the molecules showed good gastrointestinal absorption properties in the in silico studies.

Keywords

4-ASA, Hydrazide, Hydrazone, Amide, Antibacterial activity.

Supporting Institution

TUBITAK

Project Number

This study was granted by TUBITAK 2209-A 2021/1 1919B012100499

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Göknil Coşkun ^*
0000-0001-5168-3866
Türkiye

Akın Aklamuz This is me
0000-0003-2374-3061
Türkiye

Ufuk İnce This is me
0000-0002-7316-4802
Türkiye

Mert Ülgen
0000-0003-4913-4950
Türkiye

Publication Date

September 30, 2022

Submission Date

April 22, 2022

Acceptance Date

June 30, 2022

Published in Issue

Year 2022 Volume: 43 Number: 3

DOI

https://doi.org/10.17776/csj.1105811

IZ

https://izlik.org/JA62AA68PT

APA

Coşkun, G., Aklamuz, A., İnce, U., & Ülgen, M. (2022). Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal, 43(3), 384-390. https://doi.org/10.17776/csj.1105811

AMA

1.Coşkun G, Aklamuz A, İnce U, Ülgen M. Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. CSJ. 2022;43(3):384-390. doi:10.17776/csj.1105811

Chicago

Coşkun, Göknil, Akın Aklamuz, Ufuk İnce, and Mert Ülgen. 2022. “Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds”. Cumhuriyet Science Journal 43 (3): 384-90. https://doi.org/10.17776/csj.1105811.

EndNote

Coşkun G, Aklamuz A, İnce U, Ülgen M (September 1, 2022) Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal 43 3 384–390.

IEEE

[1]G. Coşkun, A. Aklamuz, U. İnce, and M. Ülgen, “Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds”, CSJ, vol. 43, no. 3, pp. 384–390, Sept. 2022, doi: 10.17776/csj.1105811.

ISNAD

Coşkun, Göknil - Aklamuz, Akın - İnce, Ufuk - Ülgen, Mert. “Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds”. Cumhuriyet Science Journal 43/3 (September 1, 2022): 384-390. https://doi.org/10.17776/csj.1105811.

JAMA

1.Coşkun G, Aklamuz A, İnce U, Ülgen M. Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. CSJ. 2022;43:384–390.

MLA

Coşkun, Göknil, et al. “Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds”. Cumhuriyet Science Journal, vol. 43, no. 3, Sept. 2022, pp. 384-90, doi:10.17776/csj.1105811.

Vancouver

1.Göknil Coşkun, Akın Aklamuz, Ufuk İnce, Mert Ülgen. Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. CSJ. 2022 Sep. 1;43(3):384-90. doi:10.17776/csj.1105811

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