Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group

Ayşegül Köse

doi:10.17776/csj.1114040

EN

Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group

Abstract

In this work, a new homo-disulphide Schiff base compound (HDSB) was prepared and its structure was characterised by common spectroscopic and analytical methods. The compound was obatined from the condensation reaction of 2-aminothiophenol and 2-hydroxy-4-(prop-2-yn-1-yloxy)benzaldehyde in benzene. In the reaction, both Schiff base condensation and oxidation of thiols into disulphide formed. The isolated compound was structurally characterized by single crystal X-ray diffraction experiment. The homo-disulphide Schiff base compound (HDSB) was screened for its DNA/BSA binding properties using UV-Vis absorption and emission spectral studies. The compound showed considerable binding affinity to double-stranded fish sperm DNA (FSds-DNA) with binding constant of 4.1 × 104 M-1. Spectral measurements suggest that HDSB interacts with DNA in a minor groove binding mode. The compound also showed binding properties towards BSA (bovine serum albumin). The incremental addition of HDSB to the BSA solution resulted in a significant decrease in the characteristic emission band of BSA in the range of 320-500 nm (λexc: 280 nm) showing the binding interactions between HDSB and BSA.

Keywords

Homo-disulphide Schiff base, Structural characterization, DNA/BSA binding, Spectroscopy

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Ayşegül Köse ^*
0000-0003-3323-8149
Türkiye

Publication Date

December 27, 2022

Submission Date

May 9, 2022

Acceptance Date

September 7, 2022

Published in Issue

Year 2022 Volume: 43 Number: 4

DOI

https://doi.org/10.17776/csj.1114040

IZ

https://izlik.org/JA56KM46BF

APA

Köse, A. (2022). Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group. Cumhuriyet Science Journal, 43(4), 613-620. https://doi.org/10.17776/csj.1114040

AMA

1.Köse A. Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group. CSJ. 2022;43(4):613-620. doi:10.17776/csj.1114040

Chicago

Köse, Ayşegül. 2022. “Synthesis, Structural Characterization and Investigation of DNA BSA Binding Properties of a Homo-Disulphide Schiff Base Compound Carrying Oxo Propargyl Group”. Cumhuriyet Science Journal 43 (4): 613-20. https://doi.org/10.17776/csj.1114040.

EndNote

Köse A (December 1, 2022) Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group. Cumhuriyet Science Journal 43 4 613–620.

IEEE

[1]A. Köse, “Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group”, CSJ, vol. 43, no. 4, pp. 613–620, Dec. 2022, doi: 10.17776/csj.1114040.

ISNAD

Köse, Ayşegül. “Synthesis, Structural Characterization and Investigation of DNA BSA Binding Properties of a Homo-Disulphide Schiff Base Compound Carrying Oxo Propargyl Group”. Cumhuriyet Science Journal 43/4 (December 1, 2022): 613-620. https://doi.org/10.17776/csj.1114040.

JAMA

1.Köse A. Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group. CSJ. 2022;43:613–620.

MLA

Köse, Ayşegül. “Synthesis, Structural Characterization and Investigation of DNA BSA Binding Properties of a Homo-Disulphide Schiff Base Compound Carrying Oxo Propargyl Group”. Cumhuriyet Science Journal, vol. 43, no. 4, Dec. 2022, pp. 613-20, doi:10.17776/csj.1114040.

Vancouver

1.Ayşegül Köse. Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group. CSJ. 2022 Dec. 1;43(4):613-20. doi:10.17776/csj.1114040

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December

Abstract

Synthesis, Structural Characterization and Investigation of DNA/BSA Binding Properties of a Homo-disulphide Schiff Base Compound Carrying Oxo Propargyl Group

Abstract

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References

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