Retinoblastoma Radiotherapy Treatment Optimizations Through GATE Simulations
Abstract
One of the most frequent children tumors in the area around the eyes is defined as retinoblastoma. Proton radiotherapy treatment is a particularly effective type of radiation therapy due to the prolonged survival rates of children with childhood cancers such as retinablastoma, continued growth of nearby organs and tissues, low radiation dose restriction of vision-related tissues and systems of these tissues. In this study, a geometry phantom including eyeball, lens, lacrimal gland, optic nerve, optic chiasm, retina, cancer, cornea and bone structures was modeled with Monte Carlo simulation tool GATE (vGATE 9.0). With this simulation, the doses absorbed by the tissues were calculated using the DoseActor and TLEDoseActor algorithms. Secondary doses were determined by the TLEDoseActor algorithm. Determination of secondary radiations is important because of the low radiation dose limit of tissues and systems that affect vision. The best treatment results were tried to be obtained by giving the beam thickness of the radiation used in our study, 4 different angles towards the target and different energies. These results show that it can be helpful in calculating a treatment plan for proton therapy in clinical practice.
Keywords
GATE, DoseActor, TLEDoseActor, Proton therapy, Retinablastoma, Radiotherapy.
References
- [1] Munier F., Vervey J., Pica A., (Eds). New Developments İn External Beam Radiotherapy for Retinoblastoma: From Lens To Normal Tissue-Sparing Techniques, Clinical Experiments Ophthalmology, 36 (2008) 78-89.
- [2] Lee T., Bilton D., Famiglietti R., (Eds). Treatment Planning With Protons For Pediatric Retinoblastoma, Medulloblastoma, And Pelvic Sarcoma: How Do Protons Compare With Other Conformal Techniques, Internation Journal Radiation Oncology Biology Physics, 36 (2005) 362–372.
- [3] M P Mehta, Proton Therapy Predictions for the Next Decade, Miami Cancer Institute, July 06, 2020.
- [4] Paganetti H. (Eds). Proton Therapy Physics. 1 nd ed. Boston, (2012) 516-544.
- [5] Geant 4 A Sımılatıon Toolkıt Available at: https://geant4.web.cern.ch?, statfacts_page=corp. Retrieved August 17, 2022.
- [6] GateOpenGate Collaboration Available at: https://opengate.readthedocs.io/en/latest/introduction /html? , statfacts_page=corp. Retrieved August 17, 2022.
- [7] Başmak H., Gözün Anatomisi ve Fizyolojisi. 1 nd ed. Eskişehir, (2005) 12-44.
- [8] Valentın J.,(Eds). Internatıon Commıssıon On Radıologıcal Protectıon Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values, ICRP Publication 89, 32 (3-4) (2002) 217-220
- [9] Allisy A. (Eds). Reports of the International Commission on Radiation Units and Measurements, ICRU Publication 46, 24 (1) (1992) 19-24
- [10] Stafford S., Pollock B., Leavitt J., A Study Of The Radiation Tolerance Of The Optic Nerves And Chiasm After Stereotactic Radiosurgery, International Journal Radiation Oncology Biology Physics, 55, (2003) 77-81.