Electrochemical Oxidation of Ranitidine using a Boron-Doped Diamond Electrode in the Presence of Anionic Surfactant: A Comprehensive Investigation
Abstract
Ranitidine (RAN) is a drug from the histamine H2 receptor antagonist class and is used to prevent excessive production of stomach acid. An electrochemical investigation of the RAN in pharmaceutical preparation and spiked human urine was performed for the using a boron-doped diamond electrode (BDDE). Voltammetric measurements were performed in a pH 11 BR solution supplemented with the anionic surfactant, sodium dodecyl sulfate (SDS). In the proposed method using optimized experimental conditions, linearity was obtained for RAN in the concentration range of 0.8-50.0 μM. The LOD value obtained is 0.22 μM. Good selectivity, accuracy, precision, and acceptable repeatability were also achieved in this proposed electrochemical sensor. Finally, this electrochemical sensor was successfully used for RAN detection in pharmaceutical samples.
Keywords
Ranitidine, Electrochemical detection, Boron-doped diamond electrode, Surfactant, Pharmaceutical samples
References
- [1] Helman C. A., Tim L. O., Pharmacology and Clinical Efficacy of Ranitidine, a New H2‐Receptor Antagonist, Pharmacother. J. Hum. Pharmacol. Drug Ther., 3(4) (1983) 185-191.
- [2] Dawson J., Richards D. A., Stables R., Dixon G. T., Cockel R., Ranitidine—Pharmacology and Clinical use, J. Clin. Pharm. Ther., 8(1) (1983) 1-13.
- [3] Ashiru D. A., Patel R., Basit A. W., Simple and Universal HPLC-UV Method to Determine Cimetidine, Ranitidine, Famotidine, and Nizatidine ın Urine: Application to the Analysis of Ranitidine and its Metabolites in Human volunteers, J. Chromatogr. B, 860(2) (2007) 235-240.
- [4] Psoma A. K., Rousis N. I., Georgantzi E. N., Τhomaidis Ν. S., An Integrated Approach to MS-based Identification and Risk Assessment of Pharmaceutical Biotransformation in Wastewater, Sci. Total Environ., 770 (2021) 144677.
- [5] Zendelovska D., Stafilov T., Development of an HPLC method for the Determination of Ranitidine and Cimetidine in Human Plasma Following SPE, J. Pharm. Biomed. Anal., 33(2) (2003) 165-173.
- [6] Castro A., Arancibia A., Romero P., Gai M. N., Validated HPLC method for the Determination of Ranitidine in Plasma, Die Pharm. Int. J. Pharm. Sci., 58(10) (2003) 696-698.
- [7] Haque T., Takulder M. M. U., Laila S., Fatema K., Development and Validation of RP-HPLC method for Simultaneous Estimation of Naproxen and Ranitidine Hydrochloride, Pak. J. Pharm. Sci., 23(4) (2010) 379-383.
- [8] Babu B., Hemnath E., Jeyaprakash M., Krishnaveni N., Meyyanathan S., Raja R., Venkatesh D., A RP-HPLC method for Simultaneous Estimation of Ondansetron and Ranitidine in Pharmaceutical Formulation, Int. J. Heal. Allied Sci., 1(2) (2012) 129-129.
- [9] Kiszkiel-Taudul I., Starczewska B., Jabłońska A., Ionic Liquid-based Ultrasound-assisted Emulsification Microextraction for the Determination of Ranitidine in Water Samples and Pharmaceutical Preparations, New J. of Chem., 44(27) (2020) 11490-11497.
- [10] El-Naem O. A., El-Maraghy C. M., A Validated Liquid Chromatography-Tandem Mass Spectrometric method for the Determination of Co-administered Ranitidine and Metronidazole in Plasma of Human Volunteers, Anal. Met., 13(23) (2021) 2586-2595.