The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin

Ezgi Akan; Mehmet Sakıncı; Gültekin Süleymanlar; Emin Türkay Korgun; Dijle Kipmen Korgun

doi:10.17776/csj.1893745

The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin

Abstract

Chronic glomerular and tubulointerstitial fibrosis represents a major pathological process leading to end-stage renal failure. Mesenchymal stem cell (MSC) therapy has emerged as a promising approach for renal tissue repair. The identification of molecular markers associated with disease progression may contribute to the evaluation of therapeutic responses. Adiponectin has been suggested as a potential indicator in chronic kidney injury. The present study aimed to investigate adiponectin-related molecular changes following MSC therapy in a rat model of chronic renal injury. Mesenchymal stem cells were isolated from the amniotic membrane of term placentas. Chronic renal injury was induced in rats by subtotal (5/6) nephrectomy. MSCs were administered via the tail vein, and animals were evaluated at 15 and 30 days after transplantation. Protein and mRNA expression levels of adiponectin, adiponectin receptor 1, fibronectin, and phosphorylated AMP-activated protein kinase (AMPK) were assessed using Western blotting and real-time PCR. Serum and urinary adiponectin levels, as well as urinary albumin levels, were measured by rat-specific ELISA kits. Compared to control animals, nephrectomized rats exhibited increased expression levels of adiponectin, adiponectin receptor 1, fibronectin, and phosphorylated AMPK. Following MSC administration, these molecular alterations showed a declining trend. In parallel, urinary albumin levels were reduced in MSC-treated groups. The findings suggest that MSC therapy is associated with modulation of adiponectin-related molecular pathways in chronic renal injury. Adiponectin-associated changes may provide preliminary insight into molecular responses during disease progression; however, further studies are required to clarify its utility as a definitive biomarker.

Keywords

Adiponectin, Chronic renal injury, Fibrosis, Mesenchymal stem cell, Placenta

Supporting Institution

This study was supported by the Research Foundation of Akdeniz University, Turkey (Project No: TYL-2017-2398).

Ethical Statement

All experimental procedures involving animals were reviewed and approved by the Local Ethics Committee for Animal Experiments (Approval No: 70, Protocol No: 2016/09/05, Date: 29 August 2016). The committee concluded that the proposed study did not pose any ethical concerns and approved the conduct of the project accordingly. In addition, the study protocol was evaluated and approved by the Clinical Research Ethics Committee (Approval No: 464, Date: 18 August 2016). The committee confirmed that the study was scientifically and ethically appropriate and that there were no ethical objections to its implementation. All procedures involving human-related data were conducted in accordance with the ethical principles of the Declaration of Helsinki, and all experimental procedures were carried out in compliance with relevant institutional and ethical guidelines.

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Authors

Ezgi Akan
0000-0002-5589-8554
Türkiye

Mehmet Sakıncı
0000-0001-5074-0005
Türkiye

Gültekin Süleymanlar
0000-0001-7935-6402
Türkiye

Emin Türkay Korgun
0000-0003-4997-3869
Türkiye

Dijle Kipmen Korgun ^*
0000-0003-0692-7491
Türkiye

Publication Date

August 31, 2026

Submission Date

February 20, 2026

Acceptance Date

July 1, 2026

Published in Issue

Year 2026 Volume: 47 Number: 4

DOI

https://doi.org/10.17776/csj.1893745

IZ

https://izlik.org/JA76GZ99YG

APA

Akan, E., Sakıncı, M., Süleymanlar, G., Korgun, E. T., & Kipmen Korgun, D. (2026). The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin. Cumhuriyet Science Journal, 47(4), 648-658. https://doi.org/10.17776/csj.1893745

AMA

1.Akan E, Sakıncı M, Süleymanlar G, Korgun ET, Kipmen Korgun D. The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin. CSJ. 2026;47(4):648-658. doi:10.17776/csj.1893745

Chicago

Akan, Ezgi, Mehmet Sakıncı, Gültekin Süleymanlar, Emin Türkay Korgun, and Dijle Kipmen Korgun. 2026. “The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin”. Cumhuriyet Science Journal 47 (4): 648-58. https://doi.org/10.17776/csj.1893745.

EndNote

Akan E, Sakıncı M, Süleymanlar G, Korgun ET, Kipmen Korgun D (August 1, 2026) The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin. Cumhuriyet Science Journal 47 4 648–658.

IEEE

[1]E. Akan, M. Sakıncı, G. Süleymanlar, E. T. Korgun, and D. Kipmen Korgun, “The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin”, CSJ, vol. 47, no. 4, pp. 648–658, Aug. 2026, doi: 10.17776/csj.1893745.

ISNAD

Akan, Ezgi - Sakıncı, Mehmet - Süleymanlar, Gültekin - Korgun, Emin Türkay - Kipmen Korgun, Dijle. “The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin”. Cumhuriyet Science Journal 47/4 (August 1, 2026): 648-658. https://doi.org/10.17776/csj.1893745.

JAMA

1.Akan E, Sakıncı M, Süleymanlar G, Korgun ET, Kipmen Korgun D. The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin. CSJ. 2026;47:648–658.

MLA

Akan, Ezgi, et al. “The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin”. Cumhuriyet Science Journal, vol. 47, no. 4, Aug. 2026, pp. 648-5, doi:10.17776/csj.1893745.

Vancouver

1.Ezgi Akan, Mehmet Sakıncı, Gültekin Süleymanlar, Emin Türkay Korgun, Dijle Kipmen Korgun. The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin. CSJ. 2026 Aug. 1;47(4):648-5. doi:10.17776/csj.1893745

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December

The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin

Abstract

Keywords

Supporting Institution

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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