Cotinus coggygria Scop.: A study on the Investigation of in vitro Antioxidant Activity and Prevention of Ethanol-induced Rat Brain Damage
Abstract
| Cotinus coggygria Scop. (C. coggygria) has been reported to contain numerous secondary metabolites. In the present study, in vitro total phenolic and flavonoid contents and antioxidant activity of C. coggygria extract were determined. In in vivo experiments, rats were divided into four groups. Total oxidant and antioxidant status, nitric oxide, reduced glutathione, lipid peroxidation, sialic acid, advanced oxidized protein product levels and carbonic anhydrase, aryl esterase, xanthine oxidase, lactate dehydrogenase, paraoxonase, prolidase, acetylcholinesterase enzyme activities and antioxidant and glutathione-related enzyme activities were determined in all brain tissue homogenates. According to the results, aqueous C. coggygria extract shows protective properties against ethanol-induced brain damage due to various bioactive components it contains and provides restoration of biochemical parameters. Considering the data from our study, C. coggygria can be used to prevent ethanol-induced oxidative stress in brain tissue due to its strong antioxidant activity. |
Keywords
Antioxidant activity, Brain, Cotinus coggygria Scop., Ethanol, Oxidative stress
Project Number
This work was supported by Scientific Research Projects Coordination Unit of Istanbul University. Project number: UDP-19304.
Ethical Statement
This study was approved by the Istanbul University-Animal Experiments Ethics Committee (Approval no: 2015/68).
Thanks
The authors would like to thank Assoc. Prof. Sukran Kultur (Istanbul University, Faculty of Pharmacy) for the identification of the plant.
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