Research Article

Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Volume: 39 Number: 2 June 29, 2018
EN TR

Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Abstract

In this study, gamma rays were applied to the sulfadimethoxine, pyrazinamide, and chloramphenicol in the dose range of 1-15 kilogray, in order to detect radiosensitivity of paramagnetic species, which are formed after irradiation by electron paramagnetic resonance spectroscopy. Firstly, the intensities of electron paramagnetic resonance signals of the samples as a function of the microwave power were investigated at room temperature. While no signal was obtained from the unirradiated samples, the irradiated samples exhibited significant spectra. Additionally, the time dependency of the samples was analyzed to study the stability of the radicals.

Keywords

Electron Paramagnetic Resonance,Free radicals,Drug

References

  1. [1]. Gopal N.G.S., Radiation Sterilization of Pharmaceuticals and Polymers, Radiat. Phys. Chem., 12 (1978) 35-50.
  2. [2]. Diehl J.F., Food Irradiation-Past, Present and Future, Radiat. Phys. Chem., 63 (2002) 211-215.
  3. [3]. Bhat R. and Sridhar K.R., Influence of Ionizing Radiation and Conventional Food Processing Treatments on the Status of Free Radicals in Lotus Seeds: An ESR Study, J. Food Comp. Anal., 24 (2011) 563-567.
  4. [4]. Aleksieva K., Lagunov O., Dimov K. and Yordanov N.D., EPR Study on Non-and Gamma-Irradiated Herbal Pills, Radiat. Phys. Chem., 80 (2011) 767-770.
  5. [5]. Ambroż H.B., Kornacka E.M., Marciniec B. and Przybytniak G., Radical Decay in Irradiated Drugs: Flutamide, Ifosfamide, J. Radioanalyt. Nucl. Chem., 254 (2002) 293-298.
  6. [6]. Basly J.P., Bernard M. and Basly I., Electron Spin Resonance Detection of Radiosterilization of Pharmaceuticals: Application to four nitrofurans, Analyst, 123 (1998) 1753-1756.
  7. [7]. Basly J.P. and Bernard M., Radio Sterilization Dosimetry by ESR Spectroscopy: Ritodrine Hydrochloride and Comparison with other Sympathomimetics, Int. J. Pharmaceut., 149 (1997) 85-91.
  8. [8]. Delincée H., Analytical Methods to Identify Irradiated Food-a Review, Radiat. Phys. Chem., 63 (2002) 455-458.
  9. [9]. Karakirova Y. and Yordanov N., Mannitol as a Radiation Sensitive Material for Electron Paramagnetic Resonance Dosimetry, Bulgarian Chem. Commun., 47 (2015) 144-148.
  10. [10]. Ambroż H.B., Kornacka E.M., Marciniec B., Ogrodowczyk M. and Przybytniak, G.K., EPR Study of Free Radicals in Some Drugs γ-Irradiated in the Solid State, Radiat. Phys. Chem., 58 (2000) 357-366.
APA
Osmanoğlu, Ş., & Sütçü, K. (2018). Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders. Cumhuriyet Science Journal, 39(2), 380-388. https://doi.org/10.17776/csj.390570
AMA
1.Osmanoğlu Ş, Sütçü K. Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders. CSJ. 2018;39(2):380-388. doi:10.17776/csj.390570
Chicago
Osmanoğlu, Şemsettin, and Kerem Sütçü. 2018. “Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders”. Cumhuriyet Science Journal 39 (2): 380-88. https://doi.org/10.17776/csj.390570.
EndNote
Osmanoğlu Ş, Sütçü K (June 1, 2018) Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders. Cumhuriyet Science Journal 39 2 380–388.
IEEE
[1]Ş. Osmanoğlu and K. Sütçü, “Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders”, CSJ, vol. 39, no. 2, pp. 380–388, June 2018, doi: 10.17776/csj.390570.
ISNAD
Osmanoğlu, Şemsettin - Sütçü, Kerem. “Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders”. Cumhuriyet Science Journal 39/2 (June 1, 2018): 380-388. https://doi.org/10.17776/csj.390570.
JAMA
1.Osmanoğlu Ş, Sütçü K. Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders. CSJ. 2018;39:380–388.
MLA
Osmanoğlu, Şemsettin, and Kerem Sütçü. “Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders”. Cumhuriyet Science Journal, vol. 39, no. 2, June 2018, pp. 380-8, doi:10.17776/csj.390570.
Vancouver
1.Şemsettin Osmanoğlu, Kerem Sütçü. Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders. CSJ. 2018 Jun. 1;39(2):380-8. doi:10.17776/csj.390570