Electrochemical Detection of Epinephrine in The Presence of Ascorbic Acid at Poly (p-Aminobenzene Sulfonic Acid) Modified Sensor
Abstract
In this study, a rapid, reliable, selective and sensitive simultaneous
voltammetric determination of Epinephrine (EP) in the presence of ascorbic acid
at poly (p-aminobenzene sulphonic
acid, ABSA) modified sensor was aimed. The glassy carbon electrode was
successfully modified with ABSA in 0.1 M KCl solution by the cycling
voltammetry technique. The sensor, modified with a polymeric thin film, showed
excellent electrocatalytic activity against the oxidation of EP and ascorbic
acid (AA). The results showed that the oxidation potential and current
responses of EP and AA improved significantly. The modified sensor showed
excellent response with limit of detection as 50 nM in the determination of EP
at the 5.0 - 53.2 μM concentration range under optimum conditions. In real
sample analyzes performed in pharmaceutical preparation and blood serum,
recovery values were 77.3%-98.4%. The results obtained show that the modified
sensor can be applied to the detection of EP in the presence of AA. The proposed
sensor is promising for routine analysis because of its high selectivity,
reproducibility, reproducibility and long-term stability characteristics and
high recovery values obtained in pharmaceutical and biological samples.
Keywords
Epinephrine,p-aminobenzene sulfonic acid,sensor,voltammetry,voltammetry
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