Preparationand Characterization of pH-Sensitive Hydrogels Based on Crosslinked Maleic Anhydride-Styrene-Methyl Methacrylate Terpolymer
Abstract
In
this study, the hydrogels have been synthesized by the crosslinking reactions maleic
anhydride-styrene-methyl methacrylate terpolymer with N, N'-methylene-bis-acrylamide and glutaraldehyde in various
crosslinker ratios. Crosslinking reactions were carried out in the presence of tetrahydrofuran
as solvent at 25-50ºC for different time period, and the resulting material
properties compared. The best conditions for effective crosslinking, i.e., crosslinking
temperature, time and crosslinker ratios were determined for each crosslinker
type. The swelling behaviour of the hydrogels was examined in Tris-buffer
solutions at various pH at 37ºC. Swelling depending on pH was observed in the
hydrogels. The pH-dependent swelling of hydrogels was strongly influenced by
the functional group of crosslinker. The molecular structure of the hydrogels
was studied by Fourier Transform Infrared Spectroscopy and their pore structure
was investigated by using Scanning Electron Microscope.
Keywords
References
- [1]. Qiu Y., Park K., Environment-sensitive hydrogels for drug delivery, Adv. Drug Del. Rev.53 (2001) 321-339.
- [2]. İmren D., Gümüşderelioğlu M., Güner A., Synthesis and characterization of dextran hydrogels prepared with chlor- and nitrogen-containing crosslinkers, J. Appl. Polym. Sci. 102 (2006) 4213-4221.
- [3]. Dispenza C., Tripodo G., LoPresti C., Spadaro G., Giammona G., Synthesis, characterisation and properties of α, β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-maleic anhydride precursors and their stimuli-responsive hydrogels, React. Funct. Polym. 69 (2009) 565-575.
- [4]. Alzari V., Ruiu A., Nuvoli D., Sanna R., Martinez J.I., Appelhans D., Voit B., Zschoche S., Mariani A., Three component terpolymer and IPN hydrogels with response to stimuli, Polymer 55 (2014) 5305-5313.
- [5]. Singh B., Chauhan G.S., Kumar S., Chauhan N., Synthesis, characterization and swelling responses of pH sensitive psyllium and polyacryamide based hydrogels for the use in drug delivery (I), Carbohydr.Polym.67 (2007) 190-200.
- [6]. İmren D., Gümüşderelioğlu M., Güner A., In vitro release kinetics of bovine serum albumin from highly swellabledextran hydrogels, J. Appl. Polym. Sci.115 (2010) 740-747.
- [7]. Shalviri A., Chan H.K, Raval G., Abdekhodaie M.J., Liu Q., Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin, Colloids.Surf.B: Biointerfaces101 (2013) 405-413.
- [8]. Xu Q., Huang W., Jiang L., Lei Z., Li X., Deng H., KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release, Carbohydr. Polym. 97 (2013) 565-570.
- [9]. Koetting M.C.,Peppas N.A., pH-Responsivepoly(itaconicacid-co-N-vinylpyrrolidone) hydrogelswithreducedionicstrengthloadingsolutionsofferimproved oral deliverypotentialforhighisoelectricpoint-exhibitingtherapeuticproteins, Int. J.Pharm.471 (2014) 83–91.
- [10]. Akperov E.O.,Maharramov A.M., Akperov O.G., Uranyl ion adsorption using novel cross-linked maleic anhydride-allyl propionate-styrene terpolymer, Hydrometallurgy 100 (2009) 76-81.