Antifungal Activity of Some Benzimidazole-Hydrazones

Year 2019, Volume: 40 Issue: 3, 695 - 699, 30.09.2019

Derya Osmaniye Ulviye Acar Çevik

https://doi.org/10.17776/csj.579734

Cited By: 1

Abstract

In the present work, 15 4-(1-(prop-2-in-1-yl)-1H-benzoimidazole-2-yl)-N'-(substitutedmethylene)benzohydrazide
derivatives (4a-4o) were re-synthesized to evaluate their antifungal activity. Structure
identification of synthesized compounds was elucidated by ¹H-NMR, ¹³C-NMR,
and HRMS spectroscopic methods.
Inhibitory potential of the re-synthesized compounds was investigated against Candida supp. The compounds 4e
and 4l showed significant anti fungal activity. Consistent with the
activity studies, 4e was found to be potent derivative with its MIC₅₀
value of (1.95 µg/mL) against Candida
glabrata. And 4l was found to
be potent derivative with its MIC₅₀ value of (1.95 µg/mL) against Candida krusei.

Keywords

Benzimidazole, hydrazone

Bazı Benzimidazol-Hidrazonların Antifungal Etkinliği

Abstract

Mevcut
çalışmada, 15 4-(1-(prop-2-in-1-il)-1H-benzimidazol-2-il)-N’-(sübstitüemetilen) benzohidrazit
türevleri (4a-4o), antifungal
aktivitelerini değerlendirmek üzere yeniden sentezlendi. Sentezlenen bileşiklerin
yapı tanımlamaları ¹H-NMR, ¹³C-NMR ve HRMS spektroskopik
yöntemlerle açıklandı. Yeniden sentezlenen bileşiklerin antifungal etkinlikleri
Candida türlerine karşı değerlendirildi. Bileşik 4e ve 4l önemli aktivite
gösterdi. Aktivite çalışmaları ile uyumlu olarak, 4e bileşiği Candida glabrata'ya
karşı 1.95 µg / mL MIC₅₀ değeri ile güçlü bir türev olarak bulundu.
Aynı zamanda 4l bileşiği Candida krusei’ye karşı 1.95 µg / mL MIC₅₀
değeri ile güçlü bir türev olarak bulundu.

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