Acne vulgaris and effects of isotretinoin treatment

Year 2023, Volume: 3 Issue: 2, 46 - 51, 30.12.2023

Ada Beler

Abstract

This article focused on treating acne vulgaris, emphasizing isotretinoin's impact. It outlines acne's clinical characteristics and causes, covering both topical and systemic therapies, as well as dermatocosmetic approaches and laser treatments. We also discussed various acne treatment methods, including topical applications, systemic treatments, and dermatocosmetic procedures. The importance of systemic treatments like isotretinoin, especially for severe acne is emphasized. The effectiveness of isotretinoin in treating acne is examined, particularly highlighting its role in achieving long-term remission.

Keywords

Acne vulgaris, Retinoids, Isotretinoin

Akne vulgaris ve izotretinoin tedavisinin etkileri

Abstract

Bu makale, izotretinoin'in etkisini vurgulayarak akne vulgaris tedavisine odaklanmıştır. Aknenin klinik özelliklerini ve nedenlerini ana hatlarıyla ele alan makale, topikal ve sistemik tedavilerin yanı sıra dermatokozmetik yaklaşımları ve lazer tedavilerini de kapsamaktadır. Ayrıca, topikal uygulamalar, sistemik tedaviler ve dermatokozmetik prosedürler dahil olmak üzere çeşitli akne tedavi yöntemleri tartışılmıştır. Özellikle şiddetli akne için izotretinoin gibi sistemik tedavilerin önemi vurgulanmıştır. İzotretinoin'in akne tedavisindeki etkinliği incelenerek özellikle uzun süreli remisyon sağlamadaki rolü üzerinde durulmuştur.

Keywords

Akne vulgaris, Retinoidler, İzotretinoin

References

• Türk Dermatoloji Derneği. Akne ve Rozase Tanı ve Tedavi. Ankara, Türk Dermatoloji Derneği, 2018.
• Strauss JS, Krowchuk DP, Leyden JJ, Lucky AW, Shalita AR, Siegfried EC et al. Guidelines of care for Acne vulgaris management. J Am Acad Dermatol. 2007;56:651–63.
• Thibout D, Gollnick H, Bettoli V, Dréno B, Kang S, Leyden JJ et al. New insights into the management of acne: An update from the global alliance to improve outcomes in acne group. J Am Acad Dermatol. 2009;60:1–50.
• Bershad SV. The modern age of acne therapy: A review of current treatment options. Mt Sinai J Med. 2001;68:279–85.
• Akhavan A., Bershad S. Topical acne drugs. Am J Clin Dermatol. 2003;4:473–92.
• Fox L, Csongradi C, Aucamp M, du Plessis J, Gerber M. Treatment modalities for acne. molecules. 2016;21:1063.
• Bowe WP, Shalita AR. Effective over-the-counter acne treatments. Semin Cutan Med Surg. 2008;27:170–6.
• Katsambas A., Papakonstantinou A. Acne: systemic treatment. Clin Dermatol. 2004;22:412–8.
• Layton A. The use of isotretinoin in acne. Dermatoendocrinology. 2009;1:162-9.
• Strauss JS, Rapini RP, Shalita AR, Konecky E, Pochi PE, Comite H et al. Isotretinoin therapy for acne: results of a multicentre dose-response study. J Am Acad Dermatol. 1994;10:490–6.
• Dessinioti C, Zouboulis CC, Bettoli V, Rigopoulos D. Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin. J Eur Acad Dermatol Venereol. 2020;34:2229-40.
• Akyol M, Ozçelik S. Non-acne dermatologic indications for systemic isotretinoin. Am J Clin Dermatol. 2005;6:175-84.
• Pile HD, Sadiq NM. Isotretinoin, Treasure Island (FL), StatPearls Publishing, 2023.
• Bremner JD. Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed. J Affect Disord Rep. 2021;6:100230.
• Kellett S C, Gawkrodger DJ. The psychological and emotional impact of acne and the effect of treatment with isotretinoin. Br J Dermatol. 1999;140:273-82.
• Strauss JS, Leyden JJ, Lucky AW, Lookingbill DP, Drake LA, Hanifin JM et al. Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: A randomized trial comparing micronized isotretinoin with standard isotretinoin. J Am Acad Dermatol. 2001;45:196-207.
• Kaymak Y, Kalay M, Ilter N, Taner E. Incidence of depression related to isotretinoin treatment in 100 acne vulgaris patients. Psychol Rep. 2006;99:897-906.
• Huang YC, Cheng YC. Isotretinoin treatment for acne and risk of depression: a systematic review and meta-analysis. J. Am. Acad. Dermatol. 2017;76:1026–78.
• .Li C, Chen J, Wang W, Ai M, Zhang Q, Kuang L. Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis. BMJ Open. 2019;9:e021549.
• Vallerand IA, Lewinson RT, Farris MS, Sibley CD, Ramien ML, Bulloch AGM et al. Efficacy and adverse events of oral isotretinoin for acne: a systematic review. Br. J. Dermatol. 2018;178:76–85.
• Rosa FW. Teratogenicity of isotretinoin. Lancet. 1983;2:513.
• Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. New York, Academic Press, 2007.
• Paichitrojjana A, Paichitrojjana A. Oral isotretinoin and its uses in dermatology: a review. Drug Des Devel Ther. 2023;17:2573-91.