Investigations on the energy reserves of rat liver following oral exposures to nanoparticles

Year 2022, Volume: 1 Issue: 2, 8 - 14, 01.06.2022

Ahmet Bayköse Esin Gülnaz Canlı Mustafa Canlı

Abstract

The liver is the energy store of mammals and its energy budget can change due to xenobiotic stress. There is no adequate information on the effects of nanoparticles (NPs) on the energy policy of mammals. Thus, this study was undertaken to investigate the accumulation of Al2O3, CuO and TiO2 NPs in the liver of female Wistar rats (Rattus norvegicus var. albinos) following oral administrations (0, 0.5, 5, 50 mg/kg b.w./day) for 14 days. Levels of total protein, lipid and glucose were measured to determine the energy reserves of the liver. ICP-MS (Inductively coupled plasma mass spectrometry) measurement showed that NPs accumulated in the liver, as the concentrations of Al, Cu and Ti increased sharply (P<0.05). Data showed that glucose levels decreased significantly (P<0.05) after NP exposures at all doses. Similarly, lipid levels also decreased (P>0.05) at the highest doses of Al2O3 and CuO exposures. However, total protein levels did not change (P>0.05) after any NP exposure. Likewise, the total energy reserves of the liver decreased (P<0.05) after the highest NP exposures. Interestingly, data indicated that the first energy sources (glucose and lipid) of the metabolism were decreased by all NPs, indicating possible metabolic stress.

Keywords

Metal, Nanoparticle, Rat, Liver, Accumulation, Energy

Supporting Institution

Çukurova University

Project Number

(FDK.2017.8197

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