Formulation and Control of a Topical Emulsion, Containing Algerian Vitis vinifera.L Leaves Extract

Abstract

Topical emulsions find their applications in wrinkle reduction (skin aging), acne treatment and, sebum secretions regulation. For various dermatological affections, many topical formulations like sunscreens and anti-aging creams are prepared using plant-based ingredients The objective of this study was to formulate an emulsion containing Vitis vinifera. L leaves extract, and to evaluate its stability and antioxidant activity in vitro.A spectrophotometric assay of the main phenolic groups for 10 Vitis vinifera. L leave samples was performed.O/W emulsions were prepared using a nonionic surfactant polysorbate 80.1,1-diphenyl-2-picrylhydrazyl assay was performed to evaluate plant extracts and emulsions antioxidant activity. The Physical stability of the emulsions stored at 25 ºC and 40 ºC for 60 days was assessed based on various physico-chemical characteristics including color, creaming, liquefaction, centrifugation pH, and electrical conductivity. The emulsions showed good physical properties and pharmaceutical stability. The polyphenol-rich-plant-derived extract and the emulsion showed good antioxidant activities. this research allowed the development of an emulsion based on Vitis vinifera. L extract, which can be proposed for topical use. However, in vivo studies are recommended to confirm the antioxidant action of this cream.

Keywords

• Plant
• emulsio
• antioxidant
• stability
• parameters

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