Review
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Year 2024, , 58 - 72, 06.07.2024
https://doi.org/10.38093/cupmap.1464497

Abstract

References

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  • 2. Al Najjar, O. A., Alkhars, M. A., Al Molhim, S. F., AlAjmi, M. S., Alhafith, A. A., Al Najjar, M. A., & Alajmi, M. S. (2023). The impact of androgenic alopecia on the quality of life of male individuals: A cross-sectional study. Cureus, 15(10). doi:10.7759/cureus.47760.
  • 3. Alves, R. (2017). Androgenetic alopecia: a review and emerging treatments. Clinical Research in Dermatology, 4(04), 1-13. doi:10.15226/2378-1726/4/4/00164.
  • 4. Alzaid, M. Y. M. (2023). Dutasteride for androgenetic alopecia. The Egyptian Journal of Hospital Medicine, 90(1), 1098-1101. doi:10.21608/EJHM.2023.280264.
  • 5. Aukerman, E. L., & Jafferany, M. (2023). The psychological consequences of androgenetic alopecia: A systematic review. Journal of Cosmetic Dermatology, 22(1), 89-95. doi:10.1111/jocd.14983 .
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  • 8. Chan, L., & Cook, D. K. (2018). Female pattern hair loss. Australian Journal of General Practice, 47(7), 459-464. doi:10.31128/AJGP-02-18-4498.
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  • 10. Cho, C. H., Bae, J. S., & Kim, Y. U. (2010). 5α-Reductase inhibitory components as antiandrogens from herbal medicine. Journal of Acupuncture and Meridian Studies, 3(2), 116-118. doi:10.1016/S2005-2901(10)60021-0.
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  • 12. Choi, H. M., Jung, Y., Park, J., Kim, H. L., Youn, D. H., Kang, J., & Lee, S. G. (2016). Cinnamomi cortex (Cinnamomum verum) suppresses testosterone-induced benign prostatic hyperplasia by regulating 5α-reductase. Scientific Reports, 6(1), 31906. doi:10.1038/srep31906.
  • 13. Chumlea, W. C., Rhodes, T., Girman, C. J., Johnson-Levonas, A., Lilly, F. R., Wu, R., & Guo, S. S. (2004). Family history and risk of hair loss. Dermatology, 209(1), 33-39. doi:10.1159/000078584.
  • 14. Cwynar, A., Olszewska-Słonina, D., & Czajkowski, R. (2020). The impact of oxidative stress in the androgenic alopecia in women. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(1), 119-120. doi:10.5114/ada.2019.81685.
  • 15. Dallob, A., Sadick, N., Unger, W., Lipert, S., Geissler, L., Gregoire, S., & Tanaka, W. (1994). The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology & Metabolism, 79(3), 703-706. doi:10.1210/jcem.79.3.8077349.
  • 16. De Lacharrière, O., Deloche, C., Misciali, C., Piraccini, B. M., Vincenzi, C., Bastien, P., & Tosti, A. (2001). Hair diameter diversity: a clinical sign reflecting the follicle miniaturization. Archives of Dermatology, 137(5), 641-646.
  • 17. Devjani, S., Ezemma, O., Kelley, K. J., Stratton, E., & Senna, M. (2023). Androgenetic alopecia: Therapy update. Drugs, 83(8), 701-715. doi:10.1007/s40265-023-01880-x.
  • 18. Dhanotia, R., Chauhan, N. S., Saraf, D. K., & Dixit, V. K. (2011). Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Natural Product Research, 25(15), 1432-1443. doi:10.1080/14786410802632820.
  • 19. Ellis, J. A., Sinclair, R., & Harrap, S. B. (2002). Androgenetic alopecia: pathogenesis and potential for therapy. Expert Reviews in Molecular Medicine, 4(22), 1-11.
  • 20. Feldman, P. R., Gentile, P., Piwko, C., Motswaledi, H. M., Gorun, S., Pesachov, J., & Feldman, O. J. (2023). Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis. Frontiers in Medicine, 9, 3800. doi:10.3389/fmed.2022.998623.
  • 21. Fischer, T. W., Hipler, U., & Elsner, P. (2007). Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. International Journal of Dermatology, 46(1), 27-35. doi:10.1111/j.1365-4632.2007.03119.x.
  • 22. Fus-Mazurkiewicz, L., Nowiński, M., Sak, J., Mazurkiewicz, W., & Król, D. (2024). Review of current knowledge and management of androgenetic alopecia. Polish Journal of Applied Sciences, 9(3), 32-35. doi:10.34668/PJAS.2023.9.3.05.
  • 23. Guerrero, A. R., & Ch, M. K. (2011). Alopecias. Revista Médica Clínica Las Condes, 22(6), 775-783.
  • 24. Hamilton, J. B. (1951). Patterned loss of hair in man: types and incidence. Annals of the New York Academy of Sciences, 53(3), 708-728. doi:10.1111/j.1749-6632.1951.tb31971.x.
  • 25. Hirata, N., Tokunaga, M., Naruto, S., Iinuma, M., & Matsuda, H. (2007). Testosterone 5α-reductase inhibitory active constituents of Piper nigrum leaf. Biological and Pharmaceutical Bulletin, 30(12), 2402-2405. doi:10.1248/bpb.30.2402.
  • 26. Hong, G. L., Park, S. R., Jung, D. Y., Karunasagara, S., Lee, K. P., Koh, E. J., & Jung, J. Y. (2020). The therapeutic effects of Stauntonia hexaphylla in benign prostate hyperplasia are mediated by the regulation of androgen receptors and 5α-reductase type 2. Journal of Ethnopharmacology, 250, 112446. doi:10.1016/j.jep.2019.112446
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A Narrowed Look Into Plant-Derived Testosterone 5α-Reductase Inhibitors for Androgenetic Alopecia

Year 2024, , 58 - 72, 06.07.2024
https://doi.org/10.38093/cupmap.1464497

Abstract

Androgenetic alopecia (AGA) is the most prevalent cause of hair loss in men and women, resulting from a combination of genetic susceptibility and androgen hormones. Increased activity of testosterone 5α-reductase in hair follicles leads to increased synthesis of dihydrotestosterone (DHT). DHT's destructive effect on hair follicles is one of the leading reasons for hair loss. Conventional pharmacotherapeutic treatments, e.g. finasteride and minoxidil, are frequently accompanied by adverse effects and may be ineffective for certain people. Recent years have seen a rise in research on plant-derived testosterone 5α-reductase enzyme inhibitors. These herbal substances produced by various plant extracts and natural ingredients show promise in terms of fewer side effects and improved tolerability. This mini review investigates herbal testosterone 5α-reductase inhibitors for treatment AGA.

Ethical Statement

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Supporting Institution

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Thanks

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References

  • 1. Adamowicz, R., Załęcki, P., Dukiel, A., & Nowicka, D. (2022). Association between androgenetic alopecia and psychosocial disease burden: A cross-sectional survey among Polish men. Dermatology Research and Practice, 2022. doi:10.1155/2022/1845044.
  • 2. Al Najjar, O. A., Alkhars, M. A., Al Molhim, S. F., AlAjmi, M. S., Alhafith, A. A., Al Najjar, M. A., & Alajmi, M. S. (2023). The impact of androgenic alopecia on the quality of life of male individuals: A cross-sectional study. Cureus, 15(10). doi:10.7759/cureus.47760.
  • 3. Alves, R. (2017). Androgenetic alopecia: a review and emerging treatments. Clinical Research in Dermatology, 4(04), 1-13. doi:10.15226/2378-1726/4/4/00164.
  • 4. Alzaid, M. Y. M. (2023). Dutasteride for androgenetic alopecia. The Egyptian Journal of Hospital Medicine, 90(1), 1098-1101. doi:10.21608/EJHM.2023.280264.
  • 5. Aukerman, E. L., & Jafferany, M. (2023). The psychological consequences of androgenetic alopecia: A systematic review. Journal of Cosmetic Dermatology, 22(1), 89-95. doi:10.1111/jocd.14983 .
  • 6. Burns, T., Breathnach, S. M., Cox, N., & Griffiths, C. (2008). Rook's Textbook of Dermatology: John Wiley & Sons.
  • 7. Chaiyana, W., Punyoyai, C., Somwongin, S., Leelapornpisid, P., Ingkaninan, K., Waranuch, N., & Schuster, R. (2017). Inhibition of 5α-reductase, IL-6 secretion, and oxidation process of Equisetum debile Roxb. ex vaucher extract as functional food and nutraceuticals ingredients. Nutrients, 9(10), 1105. doi:10.3390/nu9101105.
  • 8. Chan, L., & Cook, D. K. (2018). Female pattern hair loss. Australian Journal of General Practice, 47(7), 459-464. doi:10.31128/AJGP-02-18-4498.
  • 9. Chittur, S., Parr, B., & Marcovici, G. (2011). Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic acid and saw palmetto extract. Evidence-Based Complementary and Alternative Medicine, 2011. doi:10.1093/ecam/nep102.
  • 10. Cho, C. H., Bae, J. S., & Kim, Y. U. (2010). 5α-Reductase inhibitory components as antiandrogens from herbal medicine. Journal of Acupuncture and Meridian Studies, 3(2), 116-118. doi:10.1016/S2005-2901(10)60021-0.
  • 11. Choi, G. S., Sim, W. Y., Kang, H., Huh, C. H., Lee, Y. W., Shantakumar, S., & Cheng, W. Y. (2022). Long-term effectiveness and safety of dutasteride versus finasteride in patients with male androgenic alopecia in South Korea: A multicentre chart review study. Annals of Dermatology, 34(5), 349. doi:10.5021/ad.22.027.
  • 12. Choi, H. M., Jung, Y., Park, J., Kim, H. L., Youn, D. H., Kang, J., & Lee, S. G. (2016). Cinnamomi cortex (Cinnamomum verum) suppresses testosterone-induced benign prostatic hyperplasia by regulating 5α-reductase. Scientific Reports, 6(1), 31906. doi:10.1038/srep31906.
  • 13. Chumlea, W. C., Rhodes, T., Girman, C. J., Johnson-Levonas, A., Lilly, F. R., Wu, R., & Guo, S. S. (2004). Family history and risk of hair loss. Dermatology, 209(1), 33-39. doi:10.1159/000078584.
  • 14. Cwynar, A., Olszewska-Słonina, D., & Czajkowski, R. (2020). The impact of oxidative stress in the androgenic alopecia in women. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(1), 119-120. doi:10.5114/ada.2019.81685.
  • 15. Dallob, A., Sadick, N., Unger, W., Lipert, S., Geissler, L., Gregoire, S., & Tanaka, W. (1994). The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology & Metabolism, 79(3), 703-706. doi:10.1210/jcem.79.3.8077349.
  • 16. De Lacharrière, O., Deloche, C., Misciali, C., Piraccini, B. M., Vincenzi, C., Bastien, P., & Tosti, A. (2001). Hair diameter diversity: a clinical sign reflecting the follicle miniaturization. Archives of Dermatology, 137(5), 641-646.
  • 17. Devjani, S., Ezemma, O., Kelley, K. J., Stratton, E., & Senna, M. (2023). Androgenetic alopecia: Therapy update. Drugs, 83(8), 701-715. doi:10.1007/s40265-023-01880-x.
  • 18. Dhanotia, R., Chauhan, N. S., Saraf, D. K., & Dixit, V. K. (2011). Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Natural Product Research, 25(15), 1432-1443. doi:10.1080/14786410802632820.
  • 19. Ellis, J. A., Sinclair, R., & Harrap, S. B. (2002). Androgenetic alopecia: pathogenesis and potential for therapy. Expert Reviews in Molecular Medicine, 4(22), 1-11.
  • 20. Feldman, P. R., Gentile, P., Piwko, C., Motswaledi, H. M., Gorun, S., Pesachov, J., & Feldman, O. J. (2023). Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis. Frontiers in Medicine, 9, 3800. doi:10.3389/fmed.2022.998623.
  • 21. Fischer, T. W., Hipler, U., & Elsner, P. (2007). Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. International Journal of Dermatology, 46(1), 27-35. doi:10.1111/j.1365-4632.2007.03119.x.
  • 22. Fus-Mazurkiewicz, L., Nowiński, M., Sak, J., Mazurkiewicz, W., & Król, D. (2024). Review of current knowledge and management of androgenetic alopecia. Polish Journal of Applied Sciences, 9(3), 32-35. doi:10.34668/PJAS.2023.9.3.05.
  • 23. Guerrero, A. R., & Ch, M. K. (2011). Alopecias. Revista Médica Clínica Las Condes, 22(6), 775-783.
  • 24. Hamilton, J. B. (1951). Patterned loss of hair in man: types and incidence. Annals of the New York Academy of Sciences, 53(3), 708-728. doi:10.1111/j.1749-6632.1951.tb31971.x.
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There are 65 citations in total.

Details

Primary Language English
Subjects Pharmacognosy
Journal Section Review Articles
Authors

Nurten Abacı 0000-0002-4144-7074

İlkay Erdoğan Orhan 0000-0002-7379-5436

Early Pub Date May 25, 2024
Publication Date July 6, 2024
Submission Date April 4, 2024
Acceptance Date May 10, 2024
Published in Issue Year 2024

Cite

APA Abacı, N., & Erdoğan Orhan, İ. (2024). A Narrowed Look Into Plant-Derived Testosterone 5α-Reductase Inhibitors for Androgenetic Alopecia. Current Perspectives on Medicinal and Aromatic Plants, 7(1), 58-72. https://doi.org/10.38093/cupmap.1464497

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