Review of the Pharmacological Properties of Crassocephalum bauchiense

Year 2025, Issue: Advanced Online Publication, 101 - 108

Christian Ezeh , Daniel Digwo , Paul Ekene Chidebelu

Abstract

Crassocephalum bauchiense, a member of the Asteraceae family, is extensively used in traditional medicine across various African regions. Ethnobotanical surveys reveal the plant's utilization in treating ailments such as gastrointestinal disorders, malaria, and inflammation. Phytochemical analyses have identified diverse bioactive compounds, including phenols, tannins, triterpenes, and alkaloids, which are attributed to its medicinal efficacy. Pharmacological investigations demonstrate that C. bauchiense exhibits significant antimicrobial, antioxidant, anti-plasmodial, antinociceptive, sedative, and anti-anxiety activities. Furthermore, it is used to boost fertility and, has been associated with low toxicity. Based on these promising properties, further research is necessary to elucidate the precise mechanisms of action, optimize extraction methods, and conduct comprehensive toxicity studies to fully harness its medicinal benefits. Understanding these aspects is crucial for the development of standardized therapeutic formulations. This review underscores the pharmacological potential of C. bauchiense and advocates for more extensive studies.

Keywords

Crassocephalum bauchiense , pharmacological properties , traditional medicine , bioactive compounds , antimicrobial , antioxidant , phytochemical

References

• Abushouk, A. I., Negida, A., Ahmed, H., and Abdel- Daim, M. M. (2017). Neuroprotective mechanisms of plant extracts against MPTP-induced neurotoxicity: Future applications in Parkinson’s disease. Biomedicine & Pharmacotherapy, 85, 635–645. https://doi.org/10.1016/j.biopha.2016.11.074
• Ekor, M. (2014). The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology, 4, 177. https://doi.org/10.3389/fphar.2013.00177
• Beshbishy, A. M., Batiha, G. E. S., Adeyemi, O. S., Yokoyama, N., and Igarashi, I. (2019). Inhibitory effects of methanolic Olea europaea and acetonic Acacia laeta on the growth of Babesia and Theileria. Asian Pacific Journal of Tropical Medicine, 12, 425–434. https://doi.org/10.4103/1995-7645.267586
• Batiha, G. E., Alkazmi, L. M., Wasef, L. G., Beshbishy, A. M., Nadwa, E. H., et al. (2020). Syzygium aromaticum L. (Myrtaceae): Traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules, 10, 202. https://doi.org/10.3390/biom10020202
• Buba, C. I., Okhale, S. E., and Muazzam, I. (2016). Garcinia kola: The phytochemistry, pharmacology and therapeutic applications. International Journal of Pharmacognosy, 3(2), 67–81.
• Wagner, R. G., Mohammed, G. H., and Noland, T. L. (1999). Critical period of interspecific competition for northern conifers associated with herbaceous vegetation. Canadian Journal of Forest Research, 29(7), 890–897. https://doi.org/10.1139/x99-055
• Nkwemeh, C. N., Tonfack, A. F., Noubissi, P. A., Sidiki, N., and Taiwe, G. S. (2023). Anxiolytic effects of an aqueous extract of Crassocephalum bauchiense Hutch (Asteraceae) in mice with possible GABAergic involvement. GSC Biological and Pharmaceutical Sciences, 22(1), 376–385. https://doi.org/10.30574/gscbps.2023.22.1.0400
• Kouame Bi, K. F. P., Coulibaly, W. K., Gooré, S. G., Ouattara, Z., Bedi, G., et al. (2022). Comparative phytochemical analysis of essential oils from different biological parts of a species of Crassocephalum in Côte d'Ivoire. International Journal of Chemical Studies, 10(6), 7–11.
• Mouokeu, R. S., Ngono, A. R. N., Lunga, P. K., Koanga, M. M., Tiabou, A. T., et al. (2011). Antibacterial and dermal toxicological profiles of ethyl acetate extract from Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae). BMC Complementary and Alternative Medicine, 11, 43. https://doi.org/10.1186/1472-6882-11-43
• Tchinda, A. T., Mouokeu, S. R., Ngono, R. A. N., Ebelle, M. R. E., Mokale, A. L. K., et al. (2015). A new ent-clerodane diterpenoid from Crassocephalum bauchiense Huch. (Asteraceae). Natural Product Research. https://doi.org/10.1080/14786419.2015.1022541
• Das, J., Chowdhury, A., Biswas, S. K., Karmakar, U. K., Syarif, S. R., et al. (2012). Cytotoxicity and antifungal activities of ethanolic and chloroform extracts of Cucumis sativus Linn (Cucurbitaceae) leaves and stems. Research Journal of Phytochemistry, 6(1), 25–30. https://doi.org/10.3923/rjphyto.2012.25.30
• Mouokeu, R. S., Ngane, R. A. N., Njateng, G. S. S., Kamtchueng, M. O., and Kuiate, J. (2014). Antifungal and antioxidant activity of Crassocephalum bauchiense (Hutch.) Milne-Redh ethyl acetate extract and fractions (Asteraceae). BMC Research Notes, 7, 244. https://doi.org/10.1186/1756-0500-7-244
• Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Raizis, A. F. A., et al. (2023). Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11. https://doi.org/10.3389/fchem.2023.1158198
• Ngoula, F., Chongsi, M. M. M., Ngouateu, O. B. K., Makona, A. M. N., Kenfack, A., et al. (2019). Effects of Crassocephalum bauchiense (Hutch) leaf aqueous extract on toxicity indicators and reproductive characteristics in Oryctolagus cuniculus exposed to potassium dichromate. Asian Pacific Journal of Reproduction, 8(6), 276– 282. https://doi.org/10.4103/2305- 0500.270105
• Bassey, S. E., and Izah, S. C. (2017). Nigerian plants with insecticidal potentials against various stages of mosquito development. ASIO Journal of Medical and Health Sciences Research, 2(1), 7– 18.
• Enechi, O. C., Okpe, C. C., Ibe, G. N., Omeje, K. O., and Ugwu, P. C. (2016). Effect of Buchholzia coriacea methanol extract on haematological indices and liver function parameters in Plasmodium berghei-infected mice. Global Veterinaria, 16(1), 57–66.
• Patel, P. K., Sahu, J., and Chandel, S. S. (2016). A detailed review on nociceptive models for the screening of analgesic activity in experimental animals. International Journal of Neurology and Physical Therapy, 2(6), 44–50.
• Akter, A., Begh, M. Z., Islam, F., and Afroz, T. (2020). Phytochemical screening and evaluation of thrombolytic, analgesic and antidiarrhoeal activity of the leaves of Cucumis sativus Linn. (Cucurbitaceae) of methanolic extracts. Journal of Pharmaceutical Sciences and Research, 12(3), 448–451.
• Taiwe, G. S., Bumd, E. N., Talla, E., Dimob, T., Sidiki, N., et al. (2012). Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents. Journal of Ethnopharmacology, 141, 234–241. https://doi.org/10.1016/j.jep.2012.02.024
• Nkwemeh, C. N., Tonfack, A. F., Noubissi, P. A., Sidiki, N., and Taiwe, G. S. (2023). Anxiolytic effects of an aqueous extract of Crassocephalum bauchiense Hutch (Asteraceae) in mice with possible GABAergic involvement. GSC Biological and Pharmaceutical Sciences, 22(1), 376–385. https://doi.org/10.30574/gscbps.2023.22.1.0400
• Alkali, W. T., Kameni, N. J. S., Ngimout, K. N., Kodji, M. J. J., Joseph, N., et al. (2025). Anticonvulsant and Anti-amnesic Effects of an Aqueous Extract of Crassocephalum bauchiense (Hutch.) Milne- Redh.(Asteraceae) in Mice Pilocarpine Model of Temporal Lobe Epilepsy. Journal of Advances in Medical and Pharmaceutical Sciences, 27(4), 105- 124.
• Chongsi, M. M. M., Manfo, T. F. P., Nyambi, P., Mouokeu, R. S., Vemo, B. N., et al. (2021). Effects of Crassocephalum bauchiense ethanolic extract on reproductive parameters in rabbit does expose to potassium dichromate. American Journal of Animal and Veterinary Sciences, 16(2), 151–161.
• Yemele, M. D., Njina, S. N., Lienou, L. L., Mapon, H. S. L., Tsague, M., et al. (2021). Acute and sub-acute toxicity of Crassocephalum bauchiense aqueous extract in female Wistar rats. World Journal of Pharmaceutical and Life Sciences, 7(8), 74–81.