Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use

Sevgi Gezici; Nazım Şekeroğlu

doi:10.38093/cupmap.1742421

Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use

Abstract

Medicinal and aromatic plants (MAPs) are widely recognized as key materials for the development of innovative pharmaceutical and nutraceutical formulations. Alongside these valuable plants, agricultural byproducts—residues derived from widely cultivated crops—are gaining increasing attention as renewable resources in the field of natural compound extraction. These byproducts include a wide array of structures such as seeds (e.g., grape, pomegranate, fig, tomato), kernels (e.g., olive, cherry, melon), stalks, and peels. This review focuses on the valorization of grape, pomegranate, and fig seeds, emphasizing their phytochemical richness and potential health-promoting properties. These seeds contain notable quantities of bioactive compounds, including polyphenols, tocopherols, unsaturated fatty acids, and sterols, which contribute to various biological effects such as antioxidant, anti-inflammatory, metabolic, and dermatological actions. Extraction methods, particularly cold pressing versus Soxhlet techniques, are critically compared in terms of oil yield and bioactive preservation. Furthermore, the review discusses the applicability of these seed-derived compounds in addressing metabolic disorders, cardiovascular conditions, and dermatological aging. Finally, the integration of these byproducts into circular bioeconomy frameworks is examined, highlighting their relevance to sustainable innovation and waste minimization. Current literature supports the perspective that strategic utilization of such fruit residues could enhance the development of functional and environmentally responsible health solutions.

Keywords

References

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Details

Primary Language

English

Subjects

Structural Biology, Pharmacognosy, Industrial Crops

Journal Section

Review

Authors

Sevgi Gezici ^*
0000-0002-4856-0221
Türkiye

Nazım Şekeroğlu
Türkiye

Early Pub Date

November 23, 2025

Publication Date

December 28, 2025

Submission Date

July 14, 2025

Acceptance Date

October 29, 2025

Published in Issue

Year 2025 Volume: 8 Number: 2

DOI

https://doi.org/10.38093/cupmap.1742421

IZ

https://izlik.org/JA57KL52HT

Cite

RIS / Bibtex

APA

Gezici, S., & Şekeroğlu, N. (2025). Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use. Current Perspectives on Medicinal and Aromatic Plants, 8(2), 125-139. https://doi.org/10.38093/cupmap.1742421

AMA

1.Gezici S, Şekeroğlu N. Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use. CUPMAP. 2025;8(2):125-139. doi:10.38093/cupmap.1742421

Chicago

Gezici, Sevgi, and Nazım Şekeroğlu. 2025. “Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use”. Current Perspectives on Medicinal and Aromatic Plants 8 (2): 125-39. https://doi.org/10.38093/cupmap.1742421.

EndNote

Gezici S, Şekeroğlu N (December 1, 2025) Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use. Current Perspectives on Medicinal and Aromatic Plants 8 2 125–139.

IEEE

[1]S. Gezici and N. Şekeroğlu, “Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use”, CUPMAP, vol. 8, no. 2, pp. 125–139, Dec. 2025, doi: 10.38093/cupmap.1742421.

ISNAD

Gezici, Sevgi - Şekeroğlu, Nazım. “Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use”. Current Perspectives on Medicinal and Aromatic Plants 8/2 (December 1, 2025): 125-139. https://doi.org/10.38093/cupmap.1742421.

JAMA

1.Gezici S, Şekeroğlu N. Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use. CUPMAP. 2025;8:125–139.

MLA

Gezici, Sevgi, and Nazım Şekeroğlu. “Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use”. Current Perspectives on Medicinal and Aromatic Plants, vol. 8, no. 2, Dec. 2025, pp. 125-39, doi:10.38093/cupmap.1742421.

Vancouver

1.Sevgi Gezici, Nazım Şekeroğlu. Sustainable Valorization of Bioactive Compounds from Grape, Pomegranate, and Fig Seeds for Pharmaceutical and Nutraceutical Use. CUPMAP. 2025 Dec. 1;8(2):125-39. doi:10.38093/cupmap.1742421