Research Article

The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study

Volume: 9 September 8, 2026
EN

The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study

Abstract

Objective / Purpose: Cutaneous abscesses represent localized inflammatory lesions influenced by microbial and host immune factors. Psychophysiological stress may further modulate inflammatory responses and lesion dynamics. The efficacy and safety of BIOAPIFIT® Abscess Area Care Ointment, a honey-based multi-component topical formulation, were evaluated in a controlled clinical setting. Materials and methods: Eighty participants with early-stage abscess-prone inflammatory skin lesions were enrolled in a 10-day controlled study. Forty subjects received topical BIOAPIFIT® ointment, while 40 controls underwent wound hygiene alone. Clinical parameters (erythema, oedema, pain/tenderness, skin integrity, dryness) were assessed on Days 0, 5, and 10 using a standardized 4-point scale. Perceived stress was measured using the PSS-10 questionnaire. Results: Baseline characteristics were comparable between groups. The treated cohort demonstrated significantly accelerated abscess rupture (2.7 ± 0.9 vs. 5.9 ± 1.3 days) and complete healing in 37 of 40 subjects by Day 10 of the experimental group, compared with only 7/40 in the control subjects. Repeated measures ANOVA confirmed highly significant time-dependent improvements and between-group differences (p < 0.001). All participants exhibited elevated perceived stress levels. No adverse events were observed. Conclusion: BIOAPIFIT® Abscess Area Care Ointment significantly accelerated inflammatory resolution and wound closure compared with hygiene alone, with excellent tolerability. Elevated stress burden within the study population may represent a relevant contextual factor in lesion development and healing dynamics.

Keywords

References

  1. 1. Chrousos, G. P. (2009). Stress and disorders of the stress system. Nature Reviews Endocrinology, 5(7), 374–381. https://doi.org/10.1038/nrendo.2009.106
  2. 2. Dhabhar, F. S. (2014). Effects of stress on immune function: The good, the bad, and the beautiful. Immunologic Research, 58(2–3), 193–210. https://doi.org/10.1007/s12026-014-8517-0
  3. 3. Jull, A. B., Cullum, N., Dumville, J. C., Westby, M. J., Deshpande, S., & Walker, N. (2015). Honey as a topical treatment for wounds. Cochrane Database of Systematic Reviews, 2015(3), Article CD005083. https://doi.org/10.1002/14651858.CD005083.pub4
  4. 4. Karakaş, F. P., Karakaş, A., Boran, Ç., Türker, A. U., Yalçın, F. N., & Bilensoy, E. (2012). The evaluation of topical administration of Bellis perennis fraction on circular excision wound healing in Wistar albino rats. Pharmaceutical Biology, 50(8), 1031–1037. DOI: 10.3109/13880209.2012.656200.
  5. 5. Kobayashi, S. D., Malachowa, N., & DeLeo, F. R. (2015). Pathogenesis of Staphylococcus aureus abscesses. The American Journal of Pathology, 185(6), 1518–1527. https://doi.org/10.1016/j.ajpath.2014.11.030
  6. 6. Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature, 454(7203), 428–435. https://doi.org/10.1038/nature07201
  7. 7. Miller, G. E., Cohen, S., & Ritchey, A. K. (2002). Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model. Health Psychology, 21(6), 531–541. https://doi.org/10.1037/0278-6133.21.6.531
  8. 8. Molan, P. C. (2001). Potential of honey in the treatment of wounds and burns. American Journal of Clinical Dermatology, 2(1), 13–19. https://doi.org/10.2165/00128071-200102010-00003

Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry

Journal Section

Research Article

Publication Date

September 8, 2026

Submission Date

February 18, 2026

Acceptance Date

August 28, 2026

Published in Issue

Year 2026 Volume: 9

APA
Oreščanin, V. (2026). The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study. Current Perspectives on Medicinal and Aromatic Plants, 9. https://doi.org/10.38093/cupmap.1892671
AMA
1.Oreščanin V. The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study. CUPMAP. 2026;9. doi:10.38093/cupmap.1892671
Chicago
Oreščanin, Višnja. 2026. “The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study”. Current Perspectives on Medicinal and Aromatic Plants 9 (September). https://doi.org/10.38093/cupmap.1892671.
EndNote
Oreščanin V (September 1, 2026) The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study. Current Perspectives on Medicinal and Aromatic Plants 9
IEEE
[1]V. Oreščanin, “The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study”, CUPMAP, vol. 9, Sept. 2026, doi: 10.38093/cupmap.1892671.
ISNAD
Oreščanin, Višnja. “The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study”. Current Perspectives on Medicinal and Aromatic Plants 9 (September 1, 2026). https://doi.org/10.38093/cupmap.1892671.
JAMA
1.Oreščanin V. The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study. CUPMAP. 2026;9. doi:10.38093/cupmap.1892671.
MLA
Oreščanin, Višnja. “The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study”. Current Perspectives on Medicinal and Aromatic Plants, vol. 9, Sept. 2026, doi:10.38093/cupmap.1892671.
Vancouver
1.Višnja Oreščanin. The Efficiency and Safety of BIOAPIFIT® Abscess Area Care Ointment in the Management of Abscess-Prone Inflammatory Skin Lesions: A Controlled Clinical Study. CUPMAP. 2026 Sep. 1;9. doi:10.38093/cupmap.1892671

-------------------------------------------------------------------------------------------------------------------------------

csm_neu_ezb_logo_670e8bf80b.jpg  Google_Scholar_logo_2015.PNG index_copernicus.jpg wclogo_block.png  logo.png  

Akademia_sosyal_bilimler_indeksi_logosu.gif  wide.png424-4243430_reviewers-for-these-journals-can-track-verify-and.png  orcid_logo.png?version=1&modificationDate=1473862307894&api=v2  1*mvsP194Golg0Dmo2rjJ-oQ.jpeg  aji.png citefactor-e1553074491226.png    logo1.jpg  semantci.png

-------------------------------------------------------------------------------------------------------------------------

88x31.png CUPMAP Journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

-----------------------------------------------------------------------------------------------------------------------------------------

Open_Access_PLoS.svg

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or  use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.