Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management

Dudu Altıntaş Gündüz; Ufuk Koca

doi:10.38093/upmap.1947667c

EN TR

Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management

Abstract

Abstract Mangrove is the name given to a group of trees and shrubs living in salt soils that provide oxygen to the plant through their lenticels in marshy and low-oxygen soils. Mangroves are an important source for a wide range of wood, such as construction, shelters, fences, and non-wood forest products such as honey, sugar, alcohol, vinegar, foliage for fodder and cattle. Various Mangrove species were also identified to treat different ailments, including skin diseases, bleeding, and snake bites, abscesses, orthopedic problems, rheumatism, kidney disorders, diabetes, ulcers, boils, asthma, hepatitis, fever, leprosy, smallpox, dysentery, epilepsy, and hypertension in ethnobotanical surveys in different countries. For instance, in the Comoros and Mauritius Islands, a decoction prepared from the root of a mangrove shrub B. gymnorhiza and five to seven leaves of Piper borbonense boiled in two cups of water, is taken to treat haemorrhage, moreover, also used for diabetes and hypertension. The mangrove plant species are a good source of potential bioactive compounds, such as flavonoids, polyphenols, terpenes, tannins and alkaloids, which exhibit variety of therapeutic properties. Although many mangrove species have been used to treat ailments traditionally by local inhabitants for an extended period, following folk traditions, the number of studied extensively. Due to such rich phytochemical composition, pharmacological studies revealed their effects on various diseases. Among them, antidepressant and antihypertensive properties are also remarkable. Antidepressant effects are explained through mechanisms such as regulating neurotransmitters such as serotonin, dopamine, and norepinephrine, modulation of the HPA axis, and reduction of oxidative stress. Likewise, effects against hypertension are associated with ACE inhibition, improvement of vascular endothelial function, and diuretic effects. The present study will investigate the impact of mangroves on hypertension and depression.

Keywords

Mangrovdan Elde Edilen Fitokimyasallar: Depresyon ve Hipertansiyon Yönetiminde Terapötik Rolü

Abstract

Mangrov, bataklık ve düşük oksijenli topraklarda yaşayan ve bitkiye lentiselleri aracılığıyla oksijen sağlayan ağaç ve çalı gruplarına verilen isimdir. Mangrovlar, inşaat, barınaklar, çitler gibi çok çeşitli odun ve bal, şeker, alkol, sirke, yem ve sığırlar için yapraklar gibi odun dışı orman ürünleri için önemli bir kaynaktır. Ayrıca, farklı ülkelerde yapılan etnobotanik araştırmalarda, çeşitli mangrov türlerinin deri hastalıkları, kanama, yılan ısırıkları, apseler, ortopedik sorunlar, romatizma, böbrek rahatsızlıkları, diyabet, ülserler, çıbanlar, astım, hepatit, ateş, cüzzam, çiçek hastalığı, dizanteri, epilepsi ve hipertansiyon gibi çeşitli rahatsızlıkların tedavisinde kullanıldığı belirlenmiştir. Örneğin, Komor ve Mauritius adalarında, B. gymnorhiza adlı mangrov çalısının kökünden ve Piper borbonense bitkisinin beş ila yedi yaprağından iki bardak suda kaynatılarak hazırlanan bir dekoksiyon, kanamayı tedavi etmek için kullanılır; ayrıca diyabet ve hipertansiyon tedavisinde de kullanılır. Mangrov bitki türleri, flavonoidler, polifenoller, terpenler, tanenler ve alkaloidler gibi çeşitli terapötik özellikler gösteren potansiyel biyoaktif bileşikler açısından zengin bir kaynaktır. Birçok mangrov türü, halk geleneklerine bağlı olarak uzun süredir yerel halk tarafından çeşitli rahatsızlıkların tedavisinde kullanılmış olsa da, kapsamlı bir şekilde incelenenlerin sayısı azdır. Bu zengin fitokimyasal bileşim nedeniyle, farmakolojik çalışmalar çeşitli hastalıklar üzerindeki etkilerini ortaya koymuştur. Bunlar arasında antidepresan ve antihipertansif özellikleri de dikkat çekicidir. Antidepresan etkiler, serotonin, dopamin ve norepinefrin gibi nörotransmitterlerin düzenlenmesi, HPA ekseninin modülasyonu ve oksidatif stresin azaltılması gibi mekanizmalarla açıklanmaktadır. Benzer şekilde, hipertansiyona karşı etkiler, ACE inhibisyonu, vasküler endotel fonksiyonunun iyileştirilmesi ve diüretik etkilerle ilişkilidir. Bu çalışma, mangrovların hipertansiyon ve depresyon üzerindeki etkisini araştıracaktır.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Review

Authors

Dudu Altıntaş Gündüz ^*
0000-0002-5133-2799
Türkiye

Ufuk Koca
0000-0002-5216-7588
Türkiye

Publication Date

July 30, 2026

Submission Date

May 10, 2026

Acceptance Date

July 13, 2026

Published in Issue

Year 2026 Volume: 9

DOI

https://doi.org/10.38093/upmap.1947667c

IZ

https://izlik.org/JA83TA56GX

Cite

RIS / Bibtex

APA

Altıntaş Gündüz, D., & Koca, U. (2026). Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management. Current Perspectives on Medicinal and Aromatic Plants, 9. https://doi.org/10.38093/upmap.1947667c

AMA

1.Altıntaş Gündüz D, Koca U. Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management. CUPMAP. 2026;9. doi:10.38093/upmap.1947667c

Chicago

Altıntaş Gündüz, Dudu, and Ufuk Koca. 2026. “Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management”. Current Perspectives on Medicinal and Aromatic Plants 9 (July). https://doi.org/10.38093/upmap.1947667c.

EndNote

Altıntaş Gündüz D, Koca U (July 1, 2026) Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management. Current Perspectives on Medicinal and Aromatic Plants 9

IEEE

[1]D. Altıntaş Gündüz and U. Koca, “Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management”, CUPMAP, vol. 9, July 2026, doi: 10.38093/upmap.1947667c.

ISNAD

Altıntaş Gündüz, Dudu - Koca, Ufuk. “Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management”. Current Perspectives on Medicinal and Aromatic Plants 9 (July 1, 2026). https://doi.org/10.38093/upmap.1947667c.

JAMA

1.Altıntaş Gündüz D, Koca U. Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management. CUPMAP. 2026;9. doi:10.38093/upmap.1947667c.

MLA

Altıntaş Gündüz, Dudu, and Ufuk Koca. “Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management”. Current Perspectives on Medicinal and Aromatic Plants, vol. 9, July 2026, doi:10.38093/upmap.1947667c.

Vancouver

1.Dudu Altıntaş Gündüz, Ufuk Koca. Mangrove-Derived Phytochemicals: Therapeutic Role in Depression and Hypertension Management. CUPMAP. 2026 Jul. 1;9. doi:10.38093/upmap.1947667c

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) is an open access, double-blinded peer-reviewed and refereed international journal published by MESMAP scientific group. The main objective of the CUPMAP is to provide an intellectual outlook on the scientific researches on Medicinal and Aromatic Plants. CUPMAP have distinguished goals to promote interdisciplinary scientific studies in which results could easily be used in industrial production on MAPs.

CUPMAP Journal follows a continuous publication model.

The publication language of the journal is English.

Journal of CUPMAP welcomes article submissions and does not charge any article submission or processing charges.

The authors should ensure that they have written entirely original works, and if the authors have used the work and/or words of others that this has been appropriately cited or quoted.

All submissions are screened by iThenticate similarity detection software and our maximum allowed score is 24% for the document in which the References section truncated.

This international scientific journal publishes high-quality research articles related to Medicinal and Aromatic Plants in the fields of science and technology such as Biology, Molecular Biology and Genetics, Chemistry, Agriculture, Biochemistry, Botany, Ethnobotany, Environmental Science, Forestry, Horticulture, Health Care & Public Health, Nutrition and Food Science, Pharmaceutical Sciences, and so on.

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) areas of interest include;

· Agricultural Practices of MAPs & NWFPs

· Aromatherapy & Phytoteraphy & Phytochemistry

· Biodiversity

· Biology & Biochemistry & Biotechnology

· Botany & Ethnobotany & Ethnopharmacology

· Conservation, Management and Sustainable Uses of MAPs & NWFPs

· Essential Oils & Secondary Plant Metabolites

· Herbal & Traditional Medicines

· Industrial Processing Technologies of MAPs

· Legislations on MAPs & NWFPs

· Literature on MAPS

· Marketing of MAPs and Products

· Molecular Cancer Therapeutics

· Molecular Modeling and Simulations

· Natural Cosmetics

· Non-Governmental & Non-Profit Organizations (NGO & NPO) on MAPs

· Pharmacognosy & Phytopharmacology & Toxicology

· Standardization and Quality of MAP Products

· Traditional & Modern Herbal Products

Publishers Ethic Rules: “Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)” is an international journal, which publishes at the highest scientific level on original research articles dealing with Medicinal and Aromatic Plants in the fields of science and technology such as Biology, Molecular Biology and Genetics, Chemistry, Agriculture, Biochemistry, Botany, Ethnobotany, Environmental Science, Forestry, Horticulture, Health Care & Public Health, Nutrition and Food Science, Pharmaceutical Sciences, and so on. Originality, high scientific quality, and citation potential are the most important criteria for a manuscript to be accepted for publication. Manuscripts submitted for evaluation should not have been previously presented or already published in an electronic or printed medium. The journal should be informed of manuscripts that have been submitted to another journal for evaluation and rejected for publication. The submission of previous reviewer reports will expedite the evaluation process. Manuscripts that have been presented in a meeting should be submitted with detailed information on the organization, including the name, date, and location of the organization. All authors submitting their works to “Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)” for publication as original articles attest that the submitted works represent their authors’ contributions and have not been copied or plagiarized in whole or in part from other works. It is necessary to agree upon standards of expected ethical behavior for all parties involved in the act of publishing: the author, the journal editor, the peer reviewer and the publisher. “Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)” ethic statements are based on COPE’s Best Practice Guidelines for Journal Editors.

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Publication Decisions: The editor is responsible for deciding which of the articles submitted to the “Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)” should be published. The editor may be guided by the policies of the CUPMAP's editorial board and constrained by such legal requirements as shall then be in force regarding libel, copyright infringement and plagiarism. The editor may confer with other editors or reviewers in making this decision.

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Contribution to Editorial Decisions: Peer review assists the editor in making editorial decisions and through the editorial communications with the author may also assist the author in improving the paper.

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All submissions are screened by a similarity detection software.
We are using iThenticate plagiarism solution and our maximum allowed score, for the document in which the Materials and Methods and References sections truncated, is 24%. Higher scores are not allowed and the author will be given the plagiarism report and the manuscript will be returned to the authors.

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Editor-in-Chief

Nazim ŞEKEROĞLU

Medicinal and Aromatic Plants

Managing Editor

İlkay ERDOĞAN ORHAN

Plant Biotechnology, Ethobotany, Pharmacology and Pharmaceutical Sciences, Pharmacognosy, Pharmaceutical Botany

Associate Editors

JJ

Jeremy J. JOHNSON

Pharmacognosy

İpek SÜNTAR

Pharmacognosy, Pharmaceutical Botany, Natural Products and Bioactive Compounds

Nadire Pelin BAHADIRLI

Ethobotany, Medicinal and Aromatic Plants

Sevgi GEZICI

Molecular Genetics, Animal Cell and Molecular Biology, Medicinal Plants

Section Editors

DD

Dr. Hari Prasad DEVKOTA

Pharmaceutical Botany

JJ

Jeremy J. JOHNSON

Pharmacognosy

BC

Belgin COŞGE ŞENKAL

Medicinal and Aromatic Plants

OK

Oya KAÇAR

Medicinal and Aromatic Plants

BB

Biljiana BAUER

Autoimmunity

Ivan SALAMON

Agricultural, Veterinary and Food Sciences, Sustainable Agricultural Development

İlkay ERDOĞAN ORHAN

Plant Biotechnology, Ethobotany, Pharmacology and Pharmaceutical Sciences, Pharmacognosy, Pharmaceutical Botany

Mİ

Memet İNAN

Medicinal and Aromatic Plants

İffet İrem ÇANKAYA

Pharmacology and Pharmaceutical Sciences, Pharmaceutical Botany

Murat TUNÇTÜRK

Applied Computing, Field Crops and Pasture Production, Agrochemicals and Biocides (Incl. Application), Industrial Crops, Medicinal and Aromatic Plants

GY

Gülsüm YALDIZ

Agricultural, Veterinary and Food Sciences, Medicinal and Aromatic Plants

Ahmad ALI

Plant Physiology, Biochemistry and Cell Biology, Enzymes, Proteomics and Intermolecular Interactions, Industrial Biotechnology, Nutrition and Dietetics, Medical Biochemistry and Metabolomics, Medicinal and Biomolecular Chemistry, Food Sciences

TB

Tülay BAKIREL

Veterinary Pharmacology

VD

Vincenzo DE FEO

Pharmacognosy

AI

Alban IBRALIU

Medicinal and Aromatic Plants

SU

Serkan URANBEY

Genetically Modified Field Crops and Pasture, Plant Biotechnology in Agriculture, Agronomy, Industrial Crops

KD

Kuntal DAS

Pharmacognosy, Phytotherapy

KD

Koula DOUKANI

Biological Sciences, Food Sciences, Food Biotechnology

AS

Agnieszka SZOPA

Pharmacognosy, Pharmaceutical Biotechnology, Pharmaceutical Botany

YC

Yaowared CHULIKHIT

Pharmacognosy

Ufuk KOCA

Pharmacology and Pharmaceutical Sciences, Pharmacognosy, Pharmaceutical Biotechnology, Pharmaceutical Botany

HK

Hasene KESKIN ÇAVDAR

Food Engineering, Functional Foods, Food Sciences (Other)

MA

Mehmet Hakkı ALMA

Computational Material Sciences

Marina KRYVTSOVA

Pharmacognosy

MS

Marina SPINU

Veterinary Sciences, Veterinary Immunology, Veterinary Microbiology

Rüveyde TUNÇTÜRK

Agricultural, Veterinary and Food Sciences, Industrial Crops, Medicinal and Aromatic Plants

Durmuş Alpaslan KAYA

Materials Science and Technologies, Medicinal Plants, Agricultural, Veterinary and Food Sciences, Medicinal and Aromatic Plants

Özlem TONÇER

Medicinal and Aromatic Plants

SK

Saliha KIRICI

Medicinal and Aromatic Plants

HÖ

Hakan ÖZER

Industrial Crops, Medicinal and Aromatic Plants

DA

Doğan ARSLAN

Industrial Crops, Medicinal and Aromatic Plants

İT

İsa TELCI

Agricultural, Veterinary and Food Sciences

ŞK

Şengül KARAMAN

Plant Physiology, Medicinal and Aromatic Plants

İbrahim TÜMEN

Pharmaceutical Botany, Nonwood Forest Products Industry, Forest Products Chemistry, Agricultural, Veterinary and Food Sciences

KK

Kürşat KORKMAZ

Soil Sciences and Plant Nutrition, Plant Nutrition and Soil Fertility, Soil Sciences and Ecology

Hamdi TEMEL

Dental Therapeutics, Pharmacology and Toxicology, Inorganic Chemistry, Bioinorganic Chemistry, Transition Metal Chemistry, Veterinary Pharmacology

Sezgin SANCAKTAROĞLU

Medicinal and Aromatic Plants

FO

Faruk OZKUTLU

Plant Physiology, Plant Nutrition and Soil Fertility

Abdulhabip ÖZEL

Agronomy, Industrial Crops, Medicinal and Aromatic Plants

NA

Nazlı ARDA

Analytical Biochemistry, Cell Development, Proliferation and Death, Animal Cell and Molecular Biology, Medical Biochemistry - Proteins, Peptides and Proteomics, Mathematical Sciences, Food Biotechnology, Food Sciences (Other), Sustainable Agricultural Development, Non-Genetically Modified Uses of Biotechnology, Agricultural Molecular Engineering of Nucleic Acids and Proteins, Enzyme and Microbial Biotechnology in Agriculture, Medicinal and Aromatic Plants

FŞ

Fatma Sezer ŞENOL DENIZ

Pharmacognosy, Pharmaceutical Botany

Dilşat BOZDOĞAN KONUŞKAN

Food Sciences, Food Technology

ND

Noureddine DJEBLI

Pharmaceutical Botany

Language Editor

KD

Kuntal DAS

Pharmacognosy, Phytotherapy

Statistics Editor

Cenk Burak ŞAHIN

Industrial Crops

International Advisory Board

JJ

Jeremy J. JOHNSON

Pharmacognosy

MA

Madalina ALBU KAYA

Leather Engineering

Agnieszka SZOPA

Plant Biotechnology, Plant Tissue and Cell Culture, Pharmacognosy, Pharmaceutical Botany, Natural Products and Bioactive Compounds, Medicinal Plants, Non-Genetically Modified Uses of Biotechnology, Plant Biotechnology in Agriculture

RA

Riccardo AMORATI

Natural Products and Bioactive Compounds, Physical Organic Chemistry, Free Radical Chemistry

DJ

Dilfuza JABBOROVA