Research Article
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Year 2019, , 11 - 22, 29.07.2019
https://doi.org/10.38093/cupmap.552083

Abstract

References

  • 1. Abdelmonem, A.M., Rasheed, S.M., Mohamed, A., 2012. Bee-honey and yogurt: a novel mixture for treating patients with vulvovaginal candidiasis during pregnancy. Archives of Gynecology and Obstetrics, 286(1), 109-114.
  • 2. Banaeian, S., Sereshti, M., Rafieian, M., Farahbod, F., Kheiri, S., 2017. Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial. Journal of Medical Mycology, 27(4), 494-500.
  • 3. Boskey, E.R., Telsch, K.M., Whaley, K.J., Moench, T.R., Cone, R.A., 1999. Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification. Infection and Immunity, 67, 5170–5175.
  • 4. Caillouette, J.C., Sharp, C.F. Jr, Zimmerman, G.J., Roy, S., 1997. Vaginal pH as a marker for bacterial pathogens and menopausal status. American Journal of Obstetrics and Gynecology, 176, 1270–1275.
  • 5. Calleja-Agius, J., Brincat, M.P., 2015. The urogenital system and the menopause. Climacteric, 18 Suppl 1,18-22.
  • 6. Darvishi, M., Jahdi, F., Hamzegardeshi, Z., Goodarzi, S., Vahedi, M., 2015. The Comparison of Vaginal Cream of Mixing Yogurt, Honey and Clotrimazole on Symptoms of Vaginal Candidiasis. Global Journal of Health Science, 7(6): 108–116.
  • 7. Klebanoff, S.J., Hillier, S.L., Eschenbach, D.A., Waltersdorph, A.M., 1991. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. Journal of Infectious Diseases, 164, 94–100.
  • 8. Larsen B., 1993. Vaginal flora in health and disease. Clinical Obstetrics and Gynecology, 36(1), 107-121.
  • 9. Milsom, I., Arvidsson, L., Ekelund, P., Molander, U., Eriksson, O., 1993. Factors influencing vaginal cytology, pH and bacterial flora in elderly women. Acta Obstetricia et Gynecologica Scandinavica, 72, 286–291.
  • 10. Oreščanin, V., Findri Guštek, Š., 2017. Application of Bioapigyn Herbal Ointment for the Treatment of Lower Genital Tract Infections. Indian Journal of Pharmaceutical Education and Research, 51(3s), 176-179.
  • 11. Panda, S., Das, A., Santa Singh, A., Pala, S., 2014. Vaginal pH: A marker for menopause. Journal of Midlife Health, 5(1), 34–37.
  • 12. Pandit, L., Ouslander, J.G., 1997. Postmenopausal vaginal atrophy and atrophic vaginitis. American Journal of Medical Science, 314, 228–231.
  • 13. Redondo-Lopez, V., Cook, R.L., Sobel, J.D., 1990. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Reviews of infectious diseases, 12, 856–872.
  • 14. Roy, S., Caillouette, J.C., Roy, T., Faden, J.S., 2004. Vaginal pH is similar to follicle-stimulating hormone for menopause diagnosis. American Journal of Obstetrics and Gynecology, 190, 1272–1277.
  • 15. Tuntiviriyapun, P., Panyakhamlerd, K., Triratanachat, S., Chatsuwan, T., Chaikittisilpa, S., Jaisamrarn, U., Taechakraichana, N., 2015. Newly developed vaginal atrophy symptoms II and vaginal pH: a better correlation in vaginal atrophy? Climacteric, 18(2), 246-251.
  • 16. Vahidroodsari, F., Ayati, S., Yousefi, Z., Saeed, S., 2010. Comparing Serum Follicle-Stimulating Hormone (FSH) Level with Vaginal pH in Women with Menopausal Symptoms. Oman Medical Journal, 25(1), 13-26.

BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS

Year 2019, , 11 - 22, 29.07.2019
https://doi.org/10.38093/cupmap.552083

Abstract




Objective / Purpose: The objective of the study was
assessment of the clinical efficacy and safety of Bioapigyn
Ò vaginal ointment and pessaries
compared to Acidosalus
Ò pessaries and vaginal probiotic in
alleviating vulvo-vaginal disorders.




Materials and
methods
: 124 females
were randomly selected into four groups (each of 31 participants) and treated
once a day for ten days with: A) Bioapigyn
Ò vaginal pessaries (one pessary per
day); B) 2.5 mL of Bioapygin
Ò vaginal ointment; C) AcidosalusÒ vaginal pessaries (one pessary per
day); D) 2.5 mL of Acidosalus
Ò vaginal probiotic. All the patients were subjected to
gynecological examination, measurement of vaginal pH, Pap test, native and KOH
test, self-assessment and clinical assessment of the symptoms at baseline and
following the therapy.




Results: Following the treatment with BioapiginÒ vaginal ointment, BioapigynÒ
pessaries, Acidosalus
Ò pessaries, AcidosalusÒ vaginal
probiotic the total score of vulvo-vaginal disorders decreased for 85.2%,
88.9%, 82.7% and 78%, respectively and vaginal pH decreased between 9.1% and 14.3%.
Native test showed normalization of the vaginal flora following the treatment
with all four products with no significant difference among the products.



Conclusion/Discussion:
Both Bioapigyn
Ò and
Acidosalus
Ò products
were highly efficient in alleviation of vulvo-vaginal disorders. The products
created unfavorable conditions for pathogenic growth through the lowering of
vaginal pH value, promoting the growth of lactobacilli, creating the environment
with low water activity and creating a protective layer on the damaged mucosa
that creates a physical barrier to the entrance of the pathogens into the cells
and enables the recovery of the vaginal mucosa.

References

  • 1. Abdelmonem, A.M., Rasheed, S.M., Mohamed, A., 2012. Bee-honey and yogurt: a novel mixture for treating patients with vulvovaginal candidiasis during pregnancy. Archives of Gynecology and Obstetrics, 286(1), 109-114.
  • 2. Banaeian, S., Sereshti, M., Rafieian, M., Farahbod, F., Kheiri, S., 2017. Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial. Journal of Medical Mycology, 27(4), 494-500.
  • 3. Boskey, E.R., Telsch, K.M., Whaley, K.J., Moench, T.R., Cone, R.A., 1999. Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification. Infection and Immunity, 67, 5170–5175.
  • 4. Caillouette, J.C., Sharp, C.F. Jr, Zimmerman, G.J., Roy, S., 1997. Vaginal pH as a marker for bacterial pathogens and menopausal status. American Journal of Obstetrics and Gynecology, 176, 1270–1275.
  • 5. Calleja-Agius, J., Brincat, M.P., 2015. The urogenital system and the menopause. Climacteric, 18 Suppl 1,18-22.
  • 6. Darvishi, M., Jahdi, F., Hamzegardeshi, Z., Goodarzi, S., Vahedi, M., 2015. The Comparison of Vaginal Cream of Mixing Yogurt, Honey and Clotrimazole on Symptoms of Vaginal Candidiasis. Global Journal of Health Science, 7(6): 108–116.
  • 7. Klebanoff, S.J., Hillier, S.L., Eschenbach, D.A., Waltersdorph, A.M., 1991. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. Journal of Infectious Diseases, 164, 94–100.
  • 8. Larsen B., 1993. Vaginal flora in health and disease. Clinical Obstetrics and Gynecology, 36(1), 107-121.
  • 9. Milsom, I., Arvidsson, L., Ekelund, P., Molander, U., Eriksson, O., 1993. Factors influencing vaginal cytology, pH and bacterial flora in elderly women. Acta Obstetricia et Gynecologica Scandinavica, 72, 286–291.
  • 10. Oreščanin, V., Findri Guštek, Š., 2017. Application of Bioapigyn Herbal Ointment for the Treatment of Lower Genital Tract Infections. Indian Journal of Pharmaceutical Education and Research, 51(3s), 176-179.
  • 11. Panda, S., Das, A., Santa Singh, A., Pala, S., 2014. Vaginal pH: A marker for menopause. Journal of Midlife Health, 5(1), 34–37.
  • 12. Pandit, L., Ouslander, J.G., 1997. Postmenopausal vaginal atrophy and atrophic vaginitis. American Journal of Medical Science, 314, 228–231.
  • 13. Redondo-Lopez, V., Cook, R.L., Sobel, J.D., 1990. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Reviews of infectious diseases, 12, 856–872.
  • 14. Roy, S., Caillouette, J.C., Roy, T., Faden, J.S., 2004. Vaginal pH is similar to follicle-stimulating hormone for menopause diagnosis. American Journal of Obstetrics and Gynecology, 190, 1272–1277.
  • 15. Tuntiviriyapun, P., Panyakhamlerd, K., Triratanachat, S., Chatsuwan, T., Chaikittisilpa, S., Jaisamrarn, U., Taechakraichana, N., 2015. Newly developed vaginal atrophy symptoms II and vaginal pH: a better correlation in vaginal atrophy? Climacteric, 18(2), 246-251.
  • 16. Vahidroodsari, F., Ayati, S., Yousefi, Z., Saeed, S., 2010. Comparing Serum Follicle-Stimulating Hormone (FSH) Level with Vaginal pH in Women with Menopausal Symptoms. Oman Medical Journal, 25(1), 13-26.
There are 16 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Višnja Oreščanin

štefica Findri Guštek This is me

Publication Date July 29, 2019
Published in Issue Year 2019

Cite

APA Oreščanin, V., & Findri Guštek, š. (2019). BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS. Current Perspectives on Medicinal and Aromatic Plants, 2(1), 11-22. https://doi.org/10.38093/cupmap.552083

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