THE EFFECTS OF THE SIDERITIS OZTURKII EXTRACT ON THE EXPRESSION LEVELS OF SOME APOPTOTIC GENES

Year 2018, Volume: 1 Issue: 1, 8 - 12, 28.07.2018

Ela Nur Şimşek Sezer , Tuna Uysal

Abstract

Sideritis öztürkii (Lamiaceae) Aytac & Aksoy is an
endemic species to Turkey and used as herbal tea and folk medicine in Central
Anatolia.  The purpose of this study is
to reveal the apoptotic effects of different extracts derived from S. öztürkii on DLD-1 colorectal cancer
cell line via Real Time PCR technique. By this aim, the expression levels of
apoptotic genes for each extract were determined via Real Time PCR and then the
expression levels were evaluated and compared respectively. Especially, leaf
methanol extract was found to be more effective than leaf aqueous extract in
terms of apoptosis induction. The results infer that the ironwort extracts have
different effects on pro and anti-apoptotic gene expression levels. In
conclusion, the leaf and flower extracts have apoptosis inducing activity in
the different levels on DLD-1 cell line. 

Keywords

DLD-1, endemic, Turkey

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