Year 2019, Volume 2 , Issue 2, Pages 113 - 118 2019-12-26

The Effect of Corchorus olitorius L. Extract on Viability of Breast Cancer Cells: A friend or a foe?

Günsu Soykut Çağsın [1] , Eda Becer [2] , İhsan Çalış [3] , Seda Vatansever [4]


This Corchorus olitorius L. is known to be a medicinal plant widely consumed in the Eastern Mediterranean region and has anti-bacterial, anti-inflammatory and anti-cancer properties. Breast cancer has one of the highest mortality rates among all cancers. Therefore, the main aim of the study is to evaluate the effectiveness of C. olitorius plant on viability of estrogen receptor (ER) positive breast cancer cell line, MCF-7. C. olitorius leaves first extracted with ethanol, then LC-MS/MS analysis was done for identification of phytochemicals. MTT assay was used for assessment of cell viability of MCF-7 cells. Cells were treated with C. olitorius extracts at five concentrations (5, 10, 20, 50, 100 µg/ml) and four different incubation periods (24, 48, 72, 96 h). LC-MS/MS analysis identified seven phytochemicals in the extract, mainly quercetin and caffeoylquinic acid derivatives. MTT results showed that the extract was only slightly effective in terms of reduction of cell viability at 50 and 100 µg/ml doses which were incubated for 24 and 48 h. Lower concentration doses did not show any effect in cell viability of MCF-7 cells. Longer incubation periods tend to increase cell viability of breast cancer cells. Quercetin identified within the extract  might interfere with ER and promote MCF-7 cell proliferation. Therefore, in ER positive breast adenocarcinoma, quercetin intake and doses should carefully be monitored. More studies regarding the relationship between C. olitorius, quercetin and breast cancer should be done for further clarification of the topic.

Corchorus olitorius, MCF-7, Breast cancer, Cell viability
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Primary Language en
Subjects Biology
Published Date December
Journal Section Articles
Authors

Orcid: 0000-0002-8479-1457
Author: Günsu Soykut Çağsın (Primary Author)
Institution: YAKIN DOĞU ÜNİVERSİTESİ
Country: KKTC


Orcid: 0000-0002-2378-128X
Author: Eda Becer
Institution: YAKIN DOĞU ÜNİVERSİTESİ
Country: KKTC


Orcid: 0000-0001-5489-3420
Author: İhsan Çalış
Institution: YAKIN DOĞU ÜNİVERSİTESİ
Country: KKTC


Orcid: 0000-0002-7415-9618
Author: Seda Vatansever
Institution: MANİSA CELÂL BAYAR ÜNİVERSİTESİ
Country: Turkey


Thanks The authors are thankful to Experimental Health Research Center of Health Sciences and Pharmacognosy laboratories of Near East University for their valuable support during the study.
Dates

Publication Date : December 26, 2019

APA Soykut Çağsın, G , Becer, E , Çalış, İ , Vatansever, S . (2019). The Effect of Corchorus olitorius L. Extract on Viability of Breast Cancer Cells: A friend or a foe?. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) , 2 (2) , 113-118 . Retrieved from https://dergipark.org.tr/en/pub/cupmap/issue/51022/652991