Characterization and Optimization of Phytosome Formulation Containing Alcohol-free Umckalin from Pelargonium sidoides

Year 2020, Volume: 3 Issue: 1, 49 - 53, 27.06.2020

İsmail Aslan Ahmet Arif Kurt

https://doi.org/10.38093/cupmap.737878

Cited By: 1

Abstract

This research study was designed to investigate
physicochemical properties of types of phytosome containing alcohol-free
umckalin from Pelargonium sidoides. 
Fourteen different phytosomal formulations were prepared by film method
using P. sidoides in various types of phosphatidylcholine; Phospholipon
85 G (P 85 G) and phospholipon 100H (PL 100H). 
Physicochemical properties were measured by particle size and size
distribution, zeta potential and polydispersity index of optimum 4-phytosomal
formulation. Polarized light microscopy (PLM) techniques were employed for
obtaining size distribution and surface appearance and lamellarity. The determination of vesicle types of
phytosomes was performed by using PLM. The most suitable alcohol-free
phytosome combination was chosen as PL 100H: DCP: CHOL (10: 1: 4) containing 1
% P.S (UP 4) because of its particle size and distribution (<1000 nm) and
zeta potential (<-30 mV). 

Keywords

Liposome, Phytosome, Umckalin, Pelargonium sidoides, Characterization, Alcohol- free extract

Thanks

The authors would like to special thanks to MSc. Cosm. Bekir Çakıcı and MSc Biologist Leyla Tarhan (SFA R&D Laboratories, İstanbul, Turkey) for their valuable contribution to our research article.

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