Year 2020, Volume 3 , Issue 1, Pages 49 - 53 2020-06-27

Characterization and Optimization of Phytosome Formulation Containing Alcohol-free Umckalin from Pelargonium sidoides

İ̇smail ASLAN [1] , Ahmet Arif KURT [2]


This research study was designed to investigate physicochemical properties of types of phytosome containing alcohol-free umckalin from Pelargonium sidoides.  Fourteen different phytosomal formulations were prepared by film method using P. sidoides in various types of phosphatidylcholine; Phospholipon 85 G (P 85 G) and phospholipon 100H (PL 100H).  Physicochemical properties were measured by particle size and size distribution, zeta potential and polydispersity index of optimum 4-phytosomal formulation. Polarized light microscopy (PLM) techniques were employed for obtaining size distribution and surface appearance and lamellarity. The determination of vesicle types of phytosomes was performed by using PLM. The most suitable alcohol-free phytosome combination was chosen as PL 100H: DCP: CHOL (10: 1: 4) containing 1 % P.S (UP 4) because of its particle size and distribution (<1000 nm) and zeta potential (<-30 mV). 

Liposome, Phytosome, Umckalin, Pelargonium sidoides, Characterization, Alcohol- free extract
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Primary Language en
Subjects Pharmacy
Published Date June
Journal Section Articles
Authors

Orcid: 0000-0001-7075-7103
Author: İ̇smail ASLAN (Primary Author)
Institution: Department of Pharmacy Services, Hamidiye Vocational School of Health Services, University of Health Sciences Turkey, 34668, Uskudar, Istanbul, Turkey
Country: Turkey


Orcid: 0000-0002-3490-0192
Author: Ahmet Arif KURT
Institution: SULEYMAN DEMIREL UNIVERSITY, EĞİRDİR HEALTH SERVICES VOCATIONAL SCHOOL
Country: Turkey


Thanks The authors would like to special thanks to MSc. Cosm. Bekir Çakıcı and MSc Biologist Leyla Tarhan (SFA R&D Laboratories, İstanbul, Turkey) for their valuable contribution to our research article.
Dates

Publication Date : June 27, 2020

APA Aslan, İ , Kurt, A . (2020). Characterization and Optimization of Phytosome Formulation Containing Alcohol-free Umckalin from Pelargonium sidoides . Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) , 3 (1) , 49-53 . DOI: 10.38093/cupmap.737878