Year 2020, Volume 3 , Issue 2, Pages 135 - 142 2020-12-24

Effects of Tribulus terrestris, Avena sativa and White Ginseng on Adiponectin, Leptin, Resistin, Fatty Acid Binding Protein 4, Homocysteine and Paraoxonase-1 Levels in Hypercholesterolemic Rats

Ahmet NALBANT [1] , Ali BİLGİLİ [2] , Basak HANEDAN [3] , Mehmet AKDOĞAN [4]

This study was aimed to evaluate the effects of Tribulus terrestris (TT), Avena sativa (AS), white ginseng (WG), and a triple combination (TC) powder on adipokines, homocysteine and paraoxonase-1 levels in hypercholesterolemic rats. Hypercholesterolemia in rats was induced by diet added 2% cholesterol. Herbal treatment groups consisted of Group III (TT), Group IV (AS), Group V (WG) and Group VI (triple combination of TT, AS, and WG). Significant increase in total cholesterol, LDL-C, homocysteine, leptin and resistin levels (P<0.05) and insignificant decrease in adiponectin, and paraoxonase-1 levels (P>0.05) were found in hypercholesterolemic rats. The treatment combination with TT, AS and WG significantly reduced total cholesterol, LDL-C, homocysteine, leptin and resistin levels in hypercholesterolemic rats (P<0.05). In conclusion, it was found that TT, AS and WG had positive effects on reversing the effects of hypercholesterolemia in rats. The combination treatment with TT, AS and WG may have therapeutic effects in the treatment of hypercholesterolemia.
Hypercholesterolemia, Adipokines, Homocysteine, Paraoxonase-1, Herbal treatment
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Primary Language en
Subjects Chemistry, Multidisciplinary
Journal Section Research Articles

Orcid: 0000-0003-4756-3575
Author: Ahmet NALBANT
Institution: Sakarya University, Faculty of Medicine, Department of Internal Medicine, Sakarya, Turkey
Country: Turkey

Orcid: 0000-0001-6819-7952
Author: Ali BİLGİLİ (Primary Author)
Institution: Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara, Turkey
Country: Turkey

Orcid: 0000-0003-3873-0124
Author: Basak HANEDAN
Institution: Atatürk University, Faculty of Veterinary Medicine, Department of Internal Medicine, Erzurum, Turkey
Country: Turkey

Orcid: 0000-0002-0345-8362
Author: Mehmet AKDOĞAN
Institution: Sakarya University, Faculty of Medicine, Department of Biochemistry, Sakarya, Turkey
Country: Turkey


Publication Date : December 24, 2020

APA Nalbant, A , Bi̇lgi̇li̇, A , Hanedan, B , Akdoğan, M . (2020). Effects of Tribulus terrestris, Avena sativa and White Ginseng on Adiponectin, Leptin, Resistin, Fatty Acid Binding Protein 4, Homocysteine and Paraoxonase-1 Levels in Hypercholesterolemic Rats . Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) , 3 (2) , 135-142 . DOI: 10.38093/cupmap.829184