Symptom Management in Hematopoietic Stem Cell Transplantation: A Scoping Review Coupled with Bibliometric Analysis

Abstract

Objective: Haematopoietic stem cell transplantation (HSCT) is a common treatment for various benign and genetic diseases, particularly haematologic malignancies. Despite its utility, the transplantation process and post-transplantation period significantly challenge symptom management and quality of life for patients. Methods: This study presents a scoping review integrated with a bibliometric analysis based on 59 studies retrieved from the Web of Science (WoS) database, focusing on symptom management in patients with HSCT. The search was conducted between February 18 and 21, 2025, using the terms "bone marrow transplant" OR "haematopoietic stem cell transplantation" AND "symptom management," limited to peerreviewed English articles. Of the identified studies, 15 were nursing-focused and included in the review. VOSviewer 1.6.20 was used to explore research trends and collaboration networks, while thematic analysis was conducted to categorise the findings. Results: The research spans from 2005 to 2024, with peak publications in 2013. The predominant WoS categories were health services sciences, oncology, and nursing, with palliative care and cancer survivorship as the most cited topics. The United States contributed the most publications, particularly after 2020. Most studies involved adult patients, with a significant number being randomised controlled trials (RCTs) or descriptive studies. Interventions, such as telephone counselling training, virtual reality applications, and mobile app support for nutritional habits, demonstrated effectiveness in symptom management. Conclusion: Patient-centred strategies, individualised nursing practices, and the integration of digital health technologies are crucial for effective symptom management in HSCT patients. Future research should not only evaluate the long-term effects of these approaches but also address specific gaps in the literature such as their impact on paediatric HSCT patients, caregivers, and diverse cultural populations.

Keywords

• bibliometric analysis
• haematopoietic stem cell transplantation
• nursing
• scoping review
• symptom management

References

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