Rats with Acute Gastritis Experimentally Induced with Ethanol Distribution of Mast Cells in the Liver, Lung and Kidneys

Year 2024, Volume: 1 Issue: 1, 1 - 6, 31.12.2024

Muhammed Kasım Aydın , Tuba Baksi , Zelal Karakoç , Nazan Baksi , Aydın Ketani

Abstract

Mast cells are found in systems that are in contact with the external environment, such as blood vessels, nerves, respiration, and digestion. Mast cell proteases play important roles in the regulation of humoral and cellular events in the tissue. In rodents, mast cells are of two types: mucosal and connective tissue origin. This study aimed to examine mast cells histochemically and eosinophils in the possible damage that ethanol may cause in the liver, lung, and kidneys of rats with gastritis and also to determine whether pomegranate extract affects these cells. In our study, liver, lung, and kidney tissue samples taken from rats were stained with Alcian Blue/ Safranin O, Toluidine Blue to identify mast cells, and Congo Red to identify eosinophils. In the histological evaluation, it was determined that mast cells were located especially around blood vessels. It was determined that heparin-containing mast cells were dense in liver tissue, and histamine-containing mast cells were dense in lung tissue. It was determined that mast cells were less dense in kidney tissue than in liver and lung tissues. When the locations and densities of mast cells in rats are considered, it can be said that they undertake similar tasks in functions such as vasopermeability and inflammatory cell response, as in other mammalian species.

Keywords

heparin, mast cells, histamin, rat

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