Regional Localization of Mast Cells and Eosinophils in the Small and Large Intestine of Bovine Fetuses during Pregnancy

Year 2024, Volume: 1 Issue: 1, 7 - 14, 31.12.2024

Eray Dişbudak , Fatma Çelenk , Uğur Topaloğlu , Asuman Arkaş Alklay , Hakan Sağsöz

Abstract

Mast cells and eosinophils are important components of the immune system and play pro-inflammatory and anti-inflammatory roles in complex processes associated with the regulation of the immune system. During prenatal development, the development and maturity of the fetal digestive tract is affected by hormones (e.g. endogenous cortisol release), molecular factors and various immune cell secretions (e.g. mast cells, eosinophils). We aimed to histochemically investigate the cellular localization and quantitative distribution of mast cells and eosinophils in sections and tissue layers of the small (duodenum, jejunum and ileum) and large intestine (secum, colon, rectum) of bovine fetuses during prenatal development. A total of 37 Holstein cow fetuses were used in this study. Mast cells were observed in various sizes and appearances. It was observed that mast cell sizes were small especially in the first period of pregnancy and increased as the pregnancy progressed. Their shapes were oval-round or flat spindle-like. Eosinophils were localized in the lamina propria, submucosa layers and in the tunica serosa layer and around the blood vessels in these layers. In conclusion, the presence of these cells in bovine fetal intestinal segments and their biological roles suggest that they are important in maintaining protective mucosal barrier integrity during pregnancy.

Keywords

colon, duodenum, fetus, histochemistry, intestine, mast cell

Project Number

none

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