Sıçanlarda Allium Schoenoprasum L. Etanol Ekstraktı Ve Akrilamid Uygulandıktan Sonra Hematolojik Parametrelerin Değerlendirilmesi

Abstract

Bu çalışmada, Allium schoenoprasum L. bitkisinin akrilamid toksisitesine karşı koruyucu etkisinin araştırılması amaçlanmıştır. Hayvan materyali olarak 32 adet Wistar-Albino dişi rat 4 gruba ayrıldı. Birinci grup kontrol grubunu oluşturdu. İkinci gruba 15 gün boyunca her gün 25 mg/kg Akrilamid gastrik sonda ile verildi. Üçüncü gruba 200 mg/kg Allium schoenoprasum L. etanol ekstresi gastrik sonda ile 15 gün verildi. Dördüncü gruba 25 mg/kg Acrylamide + 200 mg/kg Allium schoenoprasum L. etanol ekstresi gastrik sonda ile 15 gün verildi. Analiz sonucunda akrilamid grubundaki sıçanlarda RBC, HCT, HGB, MCV, MCH, MCHC WBC, Lenfosit, Monosit ve Eozinofil Lenfosit (%) seviyeleri düşmesine rağmen, nötrofil ve RDW miktarı arttı (P <0,05). Allium schoenoprasum L. bitkisinin akrilamit maruziyetinin olumsuz etkilerini düzeltmede etkili olabileceği belirlendi.

Keywords

• akrilamid
• allium schoenoprasum L.
• hematolojik parmetreler
• sıçan

The Evaluation Of Hematological Parameters After Administrated Allium Schoenoprasum L. Ethanol Extract And Acrylamide İn The Rats

Abstract

In this study, it was aimed to investigate the protective effect of Allium schoenoprasum L. plant against acrylamide toxicity. As animal material, 32 Wistar-Albino female rats were divided into 4 groups. The first group formed the control group. In the second group, 25 mg/kg Acrylamide was administered by gastric gavage every day for 15 days. In the third group, 200 mg/kg Allium schoenoprasum L. ethanol extract was given by gastric gavage for 15 days. In the fourth group, 25 mg/kg Acrylamide + 200 mg/kg Allium schoenoprasum L. ethanol extract was administered by gastric gavage for 15 days. As a result of the analysis, although the levels of RBC, HCT, HGB, MCV, MCH, MCHC WBC, Lymphocyte, Monocyte and Eosinophil Lymphocyte (%) decreased in rats in the acrylamide group, the amount of neutrophils and RDW increased (P<0.05). It was determined that Allium schoenoprasum L. plant may have an effect in correcting the negative effects of acrylamide exposure.

Keywords

• acrylamide
• allium schoenoprasum L
• hematological parameters
• rat

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