Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis

Vahit Ağır; Mustafa Numan Bucak

doi:10.51754/cusbed.1750799

Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis

Abstract

Spermatogenesis is a highly coordinated process that ensures the continuous production of spermatozoa in adult males. This process originates from spermatogonial stem cells (SSCs) located in the basal compartment of the seminiferous tubules. SSCs are unique among adult stem cells in that they not only maintain the stem cell pool through self-renewal but also give rise to differentiated germ cells that contribute genetically to the next generation. Spermatogenesis involves sequential stages of proliferation, meiosis, and morphological maturation, supported by Sertoli cells and regulated by endocrine signals from the hypothalamic pituitary gonadal axis. In this context, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) play essential roles by acting on Sertoli and Leydig cells, respectively, to sustain the microenvironment required for germ cell development. Leydig cell-derived testosterone exerts its effects through classical and non-classical pathways, modulating gene expression and cellular interactions critical for spermatogenesis. Furthermore, spermatozoa undergo functional maturation during epididymal transit, acquiring motility and fertilizing capacity. Understanding the biology of SSCs and the molecular and hormonal mechanisms controlling spermatogenesis has profound implications for reproductive medicine, infertility treatment, and the conservation of endangered species. Recent advances in SSC isolation, culture, and transplantation have highlighted their potential in both regenerative and reproductive applications, although significant challenges remain in maintaining their viability and purity during manipulation.

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Details

Primary Language

English

Subjects

Veterinary Sciences (Other)

Journal Section

Review

Authors

Vahit Ağır ^*
0000-0001-6271-6088
Türkiye

Mustafa Numan Bucak
0000-0002-2955-8599
Türkiye

Early Pub Date

August 20, 2025

Publication Date

August 30, 2025

Submission Date

July 25, 2025

Acceptance Date

August 14, 2025

Published in Issue

Year 2025 Volume: 10 Number: 2

DOI

https://doi.org/10.51754/cusbed.1750799

IZ

https://izlik.org/JA27DC83SK

Cite

RIS / Bibtex

APA

Ağır, V., & Bucak, M. N. (2025). Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis. Instıtute of Health Sciences Journal, 10(2), 169-187. https://doi.org/10.51754/cusbed.1750799

AMA

1.Ağır V, Bucak MN. Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis. J Cumhuriyet Univ Health Sci Inst. 2025;10(2):169-187. doi:10.51754/cusbed.1750799

Chicago

Ağır, Vahit, and Mustafa Numan Bucak. 2025. “Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis”. Instıtute of Health Sciences Journal 10 (2): 169-87. https://doi.org/10.51754/cusbed.1750799.

EndNote

Ağır V, Bucak MN (August 1, 2025) Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis. Instıtute of Health Sciences Journal 10 2 169–187.

IEEE

[1]V. Ağır and M. N. Bucak, “Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis”, J Cumhuriyet Univ Health Sci Inst, vol. 10, no. 2, pp. 169–187, Aug. 2025, doi: 10.51754/cusbed.1750799.

ISNAD

Ağır, Vahit - Bucak, Mustafa Numan. “Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis”. Instıtute of Health Sciences Journal 10/2 (August 1, 2025): 169-187. https://doi.org/10.51754/cusbed.1750799.

JAMA

1.Ağır V, Bucak MN. Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis. J Cumhuriyet Univ Health Sci Inst. 2025;10:169–187.

MLA

Ağır, Vahit, and Mustafa Numan Bucak. “Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis”. Instıtute of Health Sciences Journal, vol. 10, no. 2, Aug. 2025, pp. 169-87, doi:10.51754/cusbed.1750799.

Vancouver

1.Vahit Ağır, Mustafa Numan Bucak. Embryonic Testis Development, Anatomy and the Role of Spermatogonial Stem Cells in Spermatogenesis. J Cumhuriyet Univ Health Sci Inst. 2025 Aug. 1;10(2):169-87. doi:10.51754/cusbed.1750799