Kanser Metabolizmasında ve Metastazında Glikanların Önemi

Abstract

Glikobiyolojinin kanser mekanizmalarının anlaşılmasındaki rolü, teşhis uygulamaları ve terapötik stratejiler için bir dizi hedef sağlaması, bu bilim alanının kanser araştırmalarındaki önemini her geçen gün arttırmaktadır. Glikozilasyonun, çeşitli fizyopatolojik süreçleri kontrol eden önemli düzenleyici bir mekanizma olarak işlev görebileceği ön görülmektedir. Hücrelerdeki glikozilasyon değişimleri ve bu değişimlerin hastalıklarla olan bağlantıları, glikomun önemli ölçüde biyolojik bilgi içerdiğini göstermektedir. Glikan zincirlerinin dallanma ve uzunluklarındaki değişiklikler, yapılarında yer alan karbohidratların çeşidi, bu moleküllerin biyolojik fonksiyonlarının değişmesine neden olmaktadır. Bununla birlikte glikan bağlayıcı proteinlerin biyolojik fonksiyonlarının karakterize edilmesi, kanser araştırmalarına önemli katkılar sağlamaktadır. Farklı glikokonjugat tipleri, anahtar kanser hücresi süreçlerine ve aynı zamanda tümör mikro-ortamına müdahale ederek, kanserin ilerlemesine yol açmaktadır.

Keywords

• Kanser
• Metastaz
• Glikan
• Glikolizasyon

The Importance of Glycans in Cancer Metabolism and Metastasis

Abstract

The role of glycobiology in understanding cancer mechanisms, providing a set of targets for diagnostic applications and therapeutic strategies increases the importance of this field of science in cancer research day by day. It is predicted that glycosylation may function as an important regulatory mechanism controlling a variety of physiopathological processes. Glycosylation changes in cells and their links with disease show that the glycome contains significant biological information. Changes in the branching and length of the glycan chains, the variety of carbohydrates in their structure cause the biological functions of these molecules to change. However, characterization of the biological functions of glycan binding proteins makes important contributions to cancer research. Different types of glycoconjugates lead to cancer progression by interfering with key cancer cell processes as well as the tumor microenvironment.

Keywords

• Cancer
• Metastasis
• Glycan
• Glycosylation

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