Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development

Mehmet Ası Oktan

Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development

Abstract

Background: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. Relationships between serum apelin concentrations and dysmetabolic conditions are still controversial. The aim of this study was to investigate the association of serum apelin levels with gestational diabetes mellitus (GDM). Material and Methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GDM (n=38), without GDM pregnant (n=41), and non-pregnant healthy women (n=39). Fasting blood glucose (FBG), serum apelin, insulin and lipids were measured. BMI and HOMA-IR were calculated for all subjects. Logistic regression analysis was performed to determine predictors of GDM development. Results: Serum apelin levels (GDM = 1.99 ± 1.36 mg/ml, non-GDM pregnant = 2.95 ± 1.36 mg/ml, non-pregnant women = 2.62 ± 1.67 mg/ml) were significantly lower (p = 0.017), HOMA-IR (p = 0.024) and BMI (p < 0.001) were significantly higher in the GDM group compared with both the non-GDM and the nonpregnant women. Serum apelin levels were found to be negatively correlated with FBG (r = -0.236, p = 0.010), OGTT 1 h glucose (r = -0.346, p = 0.002) & 2 h glucose (r = -0.248, p = 0.028), HbA1c (r = -0.209, p = 0.023), HOMA-IR (r= -0.360, p < 0.001) and BMI (r = -0.299, p = 0.001). Conclusions: Serum apelin levels were significantly lower in the GDM group as compared with both the non-GDM pregnant and the non-pregnant healthy women. Low apelin levels appear to be an independent predictor of GDM development.

Keywords

GDM, Apelin, HOMA-Ir, HbA1c

References

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Details

Primary Language

English

Subjects

Gastroenterology and Hepatology

Journal Section

Research Article

Authors

Mehmet Ası Oktan
0000-0002-9322-5844
Türkiye

Publication Date

March 12, 2025

Submission Date

August 1, 2023

Acceptance Date

January 15, 2025

Published in Issue

Year 2025 Volume: 39 Number: 1

IZ

https://izlik.org/JA56XB53KE

Cite

RIS / Bibtex

APA

Oktan, M. A. (2025). Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development. Developments and Experiments in Health and Medicine, 39(1), 1-10. https://izlik.org/JA56XB53KE

AMA

1.Oktan MA. Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development. Dev Exp Health Med. 2025;39(1):1-10. https://izlik.org/JA56XB53KE

Chicago

Oktan, Mehmet Ası. 2025. “Low Apelin Levels Are Associated With a Marked Increase in Risk of Gestational Diabetes Mellitus Development”. Developments and Experiments in Health and Medicine 39 (1): 1-10. https://izlik.org/JA56XB53KE.

EndNote

Oktan MA (March 1, 2025) Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development. Developments and Experiments in Health and Medicine 39 1 1–10.

IEEE

[1]M. A. Oktan, “Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development”, Dev Exp Health Med, vol. 39, no. 1, pp. 1–10, Mar. 2025, [Online]. Available: https://izlik.org/JA56XB53KE

ISNAD

Oktan, Mehmet Ası. “Low Apelin Levels Are Associated With a Marked Increase in Risk of Gestational Diabetes Mellitus Development”. Developments and Experiments in Health and Medicine 39/1 (March 1, 2025): 1-10. https://izlik.org/JA56XB53KE.

JAMA

1.Oktan MA. Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development. Dev Exp Health Med. 2025;39:1–10.

MLA

Oktan, Mehmet Ası. “Low Apelin Levels Are Associated With a Marked Increase in Risk of Gestational Diabetes Mellitus Development”. Developments and Experiments in Health and Medicine, vol. 39, no. 1, Mar. 2025, pp. 1-10, https://izlik.org/JA56XB53KE.

Vancouver

1.Mehmet Ası Oktan. Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development. Dev Exp Health Med [Internet]. 2025 Mar. 1;39(1):1-10. Available from: https://izlik.org/JA56XB53KE