The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism

Zeynep Ece Demirbaş

The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism

Abstract

Aims: Hypoparathyroidism (HPT) is a chronic disease characterized by low calcium levels and significant psychological and physical complications. The aim of this study was to investigate the relationship between depressive symptoms and treatment adherence in patients with HPT. Materials and Methods: This cross-sectional, observational study included patients with chronic HPT from the endocrinology clinic of a tertiary care hospital. Adults receiving oral calcium and active vitamin D therapy, who volunteered to complete the Beck Depression Inventory (BDI), and who did not have any mental disability or concomitant chronic serious disease were included. Biochemical and complication data were collected, and treatment adherence was assessed on the basis of self-reported medication use. Results: Of the 33 patients (mean age 53.7 ± 12.7 years; 78.8% female), 54.5% were non-adherent to treatment. Depressive symptoms ranged from minimal to severe, with 24.3% experiencing moderate to severe symptoms. A significant association was found between HPT etiology and depressive symptom severity (p = 0.011), with moderate symptoms more common in post-operative patients (34.8% vs. 0% in non-surgical cases). A weak negative correlation was observed between depressive symptom scores and highest calcium levels (r = -0.359, p = 0.04). Conclusions: This study emphasizes the importance of treatment goals by demonstrating the negative correlation between Ca levels and BDI scores. The high prevalence of depressive symptoms and non-adherence in patients with HPT underlines the need for tailored mental health and adherence interventions.

Keywords

References

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Details

Primary Language

English

Subjects

Endocrinology, Internal Diseases

Journal Section

Research Article

Authors

Zeynep Ece Demirbaş
0000-0002-2009-4505
Türkiye

Publication Date

March 12, 2025

Submission Date

December 29, 2024

Acceptance Date

March 4, 2025

Published in Issue

Year 2025 Volume: 39 Number: 1

IZ

https://izlik.org/JA83ZN78GL

Cite

RIS / Bibtex

APA

Demirbaş, Z. E. (2025). The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism. Developments and Experiments in Health and Medicine, 39(1), 47-60. https://izlik.org/JA83ZN78GL

AMA

1.Demirbaş ZE. The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism. Dev Exp Health Med. 2025;39(1):47-60. https://izlik.org/JA83ZN78GL

Chicago

Demirbaş, Zeynep Ece. 2025. “The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism”. Developments and Experiments in Health and Medicine 39 (1): 47-60. https://izlik.org/JA83ZN78GL.

EndNote

Demirbaş ZE (March 1, 2025) The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism. Developments and Experiments in Health and Medicine 39 1 47–60.

IEEE

[1]Z. E. Demirbaş, “The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism”, Dev Exp Health Med, vol. 39, no. 1, pp. 47–60, Mar. 2025, [Online]. Available: https://izlik.org/JA83ZN78GL

ISNAD

Demirbaş, Zeynep Ece. “The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism”. Developments and Experiments in Health and Medicine 39/1 (March 1, 2025): 47-60. https://izlik.org/JA83ZN78GL.

JAMA

1.Demirbaş ZE. The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism. Dev Exp Health Med. 2025;39:47–60.

MLA

Demirbaş, Zeynep Ece. “The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism”. Developments and Experiments in Health and Medicine, vol. 39, no. 1, Mar. 2025, pp. 47-60, https://izlik.org/JA83ZN78GL.

Vancouver

1.Zeynep Ece Demirbaş. The Relationship Between Depressive Symptoms and Treatment Adherence in Patients With Hypoparathyroidism. Dev Exp Health Med [Internet]. 2025 Mar. 1;39(1):47-60. Available from: https://izlik.org/JA83ZN78GL