Castleman disease of the parotid gland (hyaline vascular type): A case report

Abstract

ABTSTRACT Castleman Disease (CD) is a rare lymphoproliferative disease characterized by painless lymph node involvement. It is infrequent in the extrathoracic area. One of the areas where it is rarely seen is the salivary glands. In this study, the diagnosis and treatment of a 38-year-old patient with localized parotid CD were presented. The patient had a mass in the left parotid gland for about 6 years. Surgery was planned after the evaluation. Left superficial parotidectomy and left second zone neck exploration was performed. Macroscopic examination of the patient's pathology sample revealed several nodular gray tissue pieces and a large solid-looking, yellow and pink tissue piece. In the microscopic examination, in addition to the reactive lymph nodes in the left zone 2 of the neck, paracortical expansion clearly separated from the parotid gland structures in the main parotid mass, prominence in the mantle zone, follicular hyperplasia, fused germinal center structures (twinning) in some of the follicles, hyalinized sclerosis with transverse entry into some germinal centers. Vascular sections (lollipop image and twinning), vascular proliferation in the interfollicular area, significant hyalinization in the vessel walls, and lymphoid proliferation with increased plasma cells were observed. The described features were reported as compatible with “Hyaline vascular type Castleman Disease”. There was no recurrence during the patient's 2.5-year follow-up period. CD is a disease diagnosed by histopathological examination. Surgical treatment is sufficient in patients with localized involvement. Patients with residual disease or multicentric cases may require more aggressive treatment.

Keywords

• Castleman disease
• parotidectomy
• salivary glands.

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