Autoimmune Interaction in the Coexistence of Hashimoto's Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis
Abstract
Immunoglobulin A nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. It can be associated with other autoimmune diseases. This case aims to present a patient with IgA nephropathy associated with severe hypothyroidism.
A 66-year-old male with type 2 diabetes mellitus, hypertension and chronic ischemic heart disease was admitted with complaints of widespread edema. Laboratory tests revealed elevated creatinine and thyroid-stimulating hormone. Initially, a kidney-protective diet and fluid intake regulation were instituted. Diuretic treatment was started due to hypervolemia, levothyroxine was initiated for hypothyroidism. Due to progression in creatinine and diuretic-resistant hypervolemia, hemodialysis was started. At this point, renal biopsy confirmed IgA nephropathy, therefore steroid and immunosuppressive treatments were initiated. The patient showed improvement in edema and general condition.
IgA nephropathy is known to occur alongside various autoimmune diseases. This case highlights the importance of considering autoimmune thyroiditis in patients presenting with rapidly progressive glomerulonephritis.
Keywords
Supporting Institution
This study did not receive support from any institution or organization.
Ethical Statement
All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.
References
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Details
Primary Language
English
Subjects
Internal Diseases
Journal Section
Case Report
Publication Date
October 26, 2026
Submission Date
October 29, 2025
Acceptance Date
August 4, 2026
Published in Issue
Year 2026 Volume: 40 Number: 4
APA
Erarslan, S., & Kaçar Koca, N. (2026). Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis. Developments and Experiments in Health and Medicine, 40(4), 555-560. https://doi.org/10.18614/dehm.1811369
AMA
1.Erarslan S, Kaçar Koca N. Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis. Dev Exp Health Med. 2026;40(4):555-560. doi:10.18614/dehm.1811369
Chicago
Erarslan, Sertaş, and Naime Kaçar Koca. 2026. “Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis”. Developments and Experiments in Health and Medicine 40 (4): 555-60. https://doi.org/10.18614/dehm.1811369.
EndNote
Erarslan S, Kaçar Koca N (October 1, 2026) Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis. Developments and Experiments in Health and Medicine 40 4 555–560.
IEEE
[1]S. Erarslan and N. Kaçar Koca, “Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis”, Dev Exp Health Med, vol. 40, no. 4, pp. 555–560, Oct. 2026, doi: 10.18614/dehm.1811369.
ISNAD
Erarslan, Sertaş - Kaçar Koca, Naime. “Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis”. Developments and Experiments in Health and Medicine 40/4 (October 1, 2026): 555-560. https://doi.org/10.18614/dehm.1811369.
JAMA
1.Erarslan S, Kaçar Koca N. Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis. Dev Exp Health Med. 2026;40:555–560.
MLA
Erarslan, Sertaş, and Naime Kaçar Koca. “Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis”. Developments and Experiments in Health and Medicine, vol. 40, no. 4, Oct. 2026, pp. 555-60, doi:10.18614/dehm.1811369.
Vancouver
1.Sertaş Erarslan, Naime Kaçar Koca. Autoimmune Interaction in the Coexistence of Hashimoto’s Thyroiditis and IgA Nephropathy: Case Report of Severe Hypothyroidism and Rapidly Progressive Glomerulonephritis. Dev Exp Health Med. 2026 Oct. 1;40(4):555-60. doi:10.18614/dehm.1811369