Genomic biomarkers for immunotherapy response in pediatric solid tumors

Safiye Aktaş

doi:10.18614/dehm.1873512

Genomic biomarkers for immunotherapy response in pediatric solid tumors

Abstract

Immunotherapy is an increasingly popular treatment strategy offering hope for many cancers. The FDA (Food and Drug Administration) has just approved the use of immune checkpoint inhibitors for treating malignancies in both adults and children. Immune checkpoint inhibitors have been more successful in treating adult cancers than in pediatric cancers. Adult tumors have a higher tumor mutation burden (TMB) than pediatric tumors. The level of microsatellite instability (MSI) in adult tumors is greater than in pediatric solid tumors due to DNA-mismatch deficiency. TMB in tumors correlates with MSI. TMB and MSI analysis are genomic biomarkers for immune checkpoint blockade response in tumors. TMB and MSI analyses have been used in clinical practice to predict which patients are candidates for immunotherapy. This review evaluates the use of TMB and MSI analysis to predict the immunotherapy response of pediatric tumors.

Keywords

References

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Details

Primary Language

English

Subjects

Pathology

Journal Section

Review

Authors

Safiye Aktaş
0000-0002-7658-5565
Türkiye

Publication Date

January 28, 2026

Submission Date

January 21, 2025

Acceptance Date

November 12, 2025

Published in Issue

Year 2026 Volume: 40 Number: 1

DOI

https://doi.org/10.18614/dehm.1873512

IZ

https://izlik.org/JA57XJ68FF

Cite

RIS / Bibtex

APA

Aktaş, S. (2026). Genomic biomarkers for immunotherapy response in pediatric solid tumors. Developments and Experiments in Health and Medicine, 40(1), 15-26. https://doi.org/10.18614/dehm.1873512

AMA

1.Aktaş S. Genomic biomarkers for immunotherapy response in pediatric solid tumors. Dev Exp Health Med. 2026;40(1):15-26. doi:10.18614/dehm.1873512

Chicago

Aktaş, Safiye. 2026. “Genomic Biomarkers for Immunotherapy Response in Pediatric Solid Tumors”. Developments and Experiments in Health and Medicine 40 (1): 15-26. https://doi.org/10.18614/dehm.1873512.

EndNote

Aktaş S (January 1, 2026) Genomic biomarkers for immunotherapy response in pediatric solid tumors. Developments and Experiments in Health and Medicine 40 1 15–26.

IEEE

[1]S. Aktaş, “Genomic biomarkers for immunotherapy response in pediatric solid tumors”, Dev Exp Health Med, vol. 40, no. 1, pp. 15–26, Jan. 2026, doi: 10.18614/dehm.1873512.

ISNAD

Aktaş, Safiye. “Genomic Biomarkers for Immunotherapy Response in Pediatric Solid Tumors”. Developments and Experiments in Health and Medicine 40/1 (January 1, 2026): 15-26. https://doi.org/10.18614/dehm.1873512.

JAMA

1.Aktaş S. Genomic biomarkers for immunotherapy response in pediatric solid tumors. Dev Exp Health Med. 2026;40:15–26.

MLA

Aktaş, Safiye. “Genomic Biomarkers for Immunotherapy Response in Pediatric Solid Tumors”. Developments and Experiments in Health and Medicine, vol. 40, no. 1, Jan. 2026, pp. 15-26, doi:10.18614/dehm.1873512.

Vancouver

1.Safiye Aktaş. Genomic biomarkers for immunotherapy response in pediatric solid tumors. Dev Exp Health Med. 2026 Jan. 1;40(1):15-26. doi:10.18614/dehm.1873512