Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi

Hasan Çalışkan; Koray Hamza Cihan; Nezahat Zaloğlu

Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi

Abstract

Anksiyete çok farklı emosyonları içeren psikolojik bir rahatsızlıktır. Anksiyete tedavisinde son yıllarda antikonvülsan ajanlarda kullanılmaktadır. Bu derlemede antikonvülsan özelliğe sahip, voltaj bağımlı kalsiyum kanallarının ligandı olan Gabapentin ve Pregabalinin hayvan anksiyete testlerindeki anksiyolitik etkisi incelenmiştir.

Keywords

Anksiyete,Gabapentin,Pregabalin

References

Stahl SM. 2015. Stahl’ın Temel Psikofarmokolojisi, Sinirsel Temeli ve Pratik Uygulaması. Ed: Prof.Dr. Tunç Alkın. S: 388-420.
Goldlust A, Su TZ, Welty DF, Taylor CP, Oxender DL. 1995. Effects of anticonvulsantdruggabapentin on theenzymes in metabolicpathways of glutamateand GABA. EpilepsyRes. 22(1):1-11.
Petroff OA, Rothman DL, Behar KL, Lamoureux D, Mattson RH. 1996. Theeffect of gabapentin on brain gamma-aminobutyricacid in patientswithepilepsy. AnnNeurol. 39(1):95-9.
Schwan S, Sundström A, Stjernberg E, Hallberg E, Hallberg P. 2010. Signalfor an abuseliabilityforpregabalinresultsfromtheSwedishspontaneousadversedrugreactionreportingsystem. Eur J ClinPharmacol. 66(9):947-953.
Amin B, Hosseinzadeh H. 2012. Evaluation of aqueousandethanolicextracts of saffron, Crocussativus L.,anditsconstituents, safranalandcrocin in allodyniaandhyperalgesiainducedbychronicconstrictioninjury model of neuropathicpain in rats. Fitoterapia. 83(5):888-95.
Young LT, Robb JC, Hasey GM, MacQueen GM, PatelisSiotis I, Marriott M, Joffe RT. 1999. Gabapentin as an adjunctivetreatment in bipolardisorder. J AffectDisord. 55(1):73-7.
Rosenberg JM, Harrell C, Ristic H, Werner RA, de Rosayro AM. 1997. Theeffect of gabapentin on neuropathicpain. Clin J Pain. 13(3):251-5.
Gahr M, Freudenmann RW, Hiemke C, Kölle MA, Schönfeldt-Lecuona C. 2013. Pregabalinabuseanddependence in Germany: resultsfrom a databasequery. Eur J ClinPharmacol. 69(6):1335-42.

Montgomery KC. 1955. Therelationbetweenfearinducedbynovelstimulationandexploratorybehavior. J CompPhysiolPsychol. 48(4): 254-260.
Handley SL, Mithani S. 1984. Effects of alpha-adrenoceptoragonistsandantagonists in a maze-exploration model of ’fear’-motivatedbehaviour. NaunynSchmiedebergsArch. Pharmacol. 327:1–5.
Pellow S, Chopin P, File SE, Briley M. 1985. Validation of open: closedarmentries in an elevatedplus-maze as a measure of anxiety in therat. J. NeurosciMethods. 14: 149-167.
Watson WP, Robinson E, Little HJ. 1997. Thenovelanticonvulsant, gabapentin, protectsagainstbothconvulsantandanxiogenicaspects of theethanolwithdrawalsyndrome. Neuropharmacology. 36(10):1369-75.
de-Paris F, Busnello JV, Vianna MR, Salgueiro JB, Quevedo J, Izquierdo I, Kapczinski F. 2000. Theanticonvulsantcompoundgabapentinpossessesanxiolytic but not amnesiceffects in rats. BehavPharmacol. 11(2):169-73.
Kulkarni SK, Singh K, Bishnoi M. 2008. Comparativebehaviouralprofile of newerantianxietydrugs on differentmazes. Indian J ExpBiol. 46(9):633-8.
Celikyurt IK, Mutlu O, Ulak G, Akar FY, Erden F. 2011. Gabapentin, A GABA analogue, enhancescognitiveperformance in mice. NeurosciLett. 492(2):124-8.
Kilic FS, Ismailoglu S, Kaygisiz B, Oner S. 2014. Effects of singleandcombinedgabapentinuse in elevatedplusmazeandforcedswimmingtests. ActaNeuropsychiatr. 26(5):307-14.
Field MJ, Oles RJ, Singh L. 2001. Pregabalinmayrepresent a novelclass of anxiolyticagentswith a broadspectrum of activity. Br J Pharmacol. 132(1):1-4.
Zohar J, Matar MA, Ifergane G, Kaplan Z, Cohen H. 2008. Brief post-stressortreatmentwithpregabalin in an animal model for PTSD: short-termanxiolyticeffectswithoutlong-termanxiogeniceffect. EurNeuropsychopharmacol. 18(9):653-666.
Hall CS. 1934. Emotionalbehavior in rat: Defactionandurination as measure of individualdiffirences in emotionality. Journal of comparativePsychology. 18: 385-403.
Cilio MR, Bolanos AR, Liu Z, Schmid R, Yang Y, Stafstrom CE, Mikati MA, Holmes GL. 2001. Anticonvulsantactionandlong-termeffects of gabapentin in theimmaturebrain. Neuropharmacology. 40(1):139-47.
Lau W, Dykstra C, Thevarkunnnel S, Silenieks LB, de Lannoyy IA, Lee DK, Higgins GA. 2013. A backtranslation of pregabalinandcarbamazepineagainstevokedandnon-evokedendpoints in theratsparednerveinjury model of neuropathicpain. Neuropharmacology. 73: 204-215.
Avila-Martin G, Galan-Arriero I, Ferrer-Donato A, Busquets X, Gomez-Soriano J, Escribá PV, Taylor J. 2015. Oral 2-hydroxyoleic acidinhibitsreflexhypersensitivityandopen-field-inducedanxietyaftersparednerveinjury. Eur J Pain. 19(1):111-22.
Galan-Arriero I, Avila-Martin G, Ferrer-Donato A, Gomez-Soriano J, Piazza S, Taylor J. 2015. Earlytreatmentwith UR13870, a novelinhibitor of p38α mitogenousactivated protein kinase, preventshyperreflexiaandanxietybehaviors, in thesparednerveinjury model of neuropathicpain. NeurosciLett. 604: 69-74.
Crawley J, Goodwin FK. 1980. Preliminary report of a simpleanimalbehavior model fortheanxiolyticeffects of benzodiazepines. PharmacolBiochemBehav. 13(2):167-70.
Navarrete F, Pérez-Ortiz JM, Manzanares J. 2012. Pregabalin- andtopiramate-mediatedregulation of cognitiveand motor impulsivity in DBA/2 mice. Br J Pharmacol. 167(1): 183-195.

Details

Primary Language

Turkish

Subjects

-

Journal Section

Research Article

Authors

Hasan Çalışkan ^* This is me
Ankara Üniversitesi
Türkiye

Koray Hamza Cihan This is me
Ankara Üniversitesi

Nezahat Zaloğlu This is me
Ankara Üniversitesi
Türkiye

Publication Date

June 1, 2017

Submission Date

February 20, 2017

Acceptance Date

April 22, 2017

Published in Issue

Year 2017 Volume: 10 Number: 1

IZ

https://izlik.org/JA95JH32ZR

Cite

RIS / Bibtex

APA

Çalışkan, H., Cihan, K. H., & Zaloğlu, N. (2017). Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi. Turkish Journal of Scientific Reviews, 10(1), 13-15. https://izlik.org/JA95JH32ZR

AMA

1.Çalışkan H, Cihan KH, Zaloğlu N. Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi. Turkish Journal of Scientific Reviews. 2017;10(1):13-15. https://izlik.org/JA95JH32ZR

Chicago

Çalışkan, Hasan, Koray Hamza Cihan, and Nezahat Zaloğlu. 2017. “Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri Ile İncelenmesi”. Turkish Journal of Scientific Reviews 10 (1): 13-15. https://izlik.org/JA95JH32ZR.

EndNote

Çalışkan H, Cihan KH, Zaloğlu N (June 1, 2017) Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi. Turkish Journal of Scientific Reviews 10 1 13–15.

IEEE

[1]H. Çalışkan, K. H. Cihan, and N. Zaloğlu, “Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi”, Turkish Journal of Scientific Reviews, vol. 10, no. 1, pp. 13–15, June 2017, [Online]. Available: https://izlik.org/JA95JH32ZR

ISNAD

Çalışkan, Hasan - Cihan, Koray Hamza - Zaloğlu, Nezahat. “Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri Ile İncelenmesi”. Turkish Journal of Scientific Reviews 10/1 (June 1, 2017): 13-15. https://izlik.org/JA95JH32ZR.

JAMA

1.Çalışkan H, Cihan KH, Zaloğlu N. Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi. Turkish Journal of Scientific Reviews. 2017;10:13–15.

MLA

Çalışkan, Hasan, et al. “Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri Ile İncelenmesi”. Turkish Journal of Scientific Reviews, vol. 10, no. 1, June 2017, pp. 13-15, https://izlik.org/JA95JH32ZR.

Vancouver

1.Hasan Çalışkan, Koray Hamza Cihan, Nezahat Zaloğlu. Alfa 2 Delta(α2δ)LigandlarınınAnksiyolitik Etkisinin Hayvan Anksiyete Testleri ile İncelenmesi. Turkish Journal of Scientific Reviews [Internet]. 2017 Jun. 1;10(1):13-5. Available from: https://izlik.org/JA95JH32ZR