Comparison of the Serum Lipid Concentratıons Between Women With Pcos and Healthy Women- a Retrospective Study

Year 2016, Volume: 30 Issue: 2, 71 - 77, 21.10.2016

Özgür Yılmaz , Halil Gürsoy Pala Tuncay Küme , Burcu Artunç Ülkümen

Abstract

Objective: Hyperlipidemia is
the one of the most common metabolic disorders in PCOS. Therefore in this study
we aim to evaluate lipid concentrations in women with or without PCOS in our
population.

Methods: Fifty five women
with PCOS and fifty five age and body mass index (BMI) matched healthy women
were retrospectively assessed. Fasting serum high-density lipoprotein(HDL) cholesterol, low-density lipoprotein (LDL) cholesterol,
and total cholesterol, triglyceride, glucose and insulin concentrations were
evaluated.

Results: There were no
significant differences between two groups according to serum fasting total
cholesterol, HDL cholesterol, LDL cholesterol, glucose and insulin
concentrations (p>0.05). Serum
triglycerides (121.13±42.633 mg/dL versus 94.444±41.809 mg/dL; p=0.004) and total tetosterone
concencentrations (46.422±18.551ng/mL versus 36.546±14.365ng/mL; p=0.006) were significantly higher in
women with PCOS. According to linear regression analysis, only triglyceride
levels were associated with PCOS (β=0.262; p=0.016).

Discussion and
conclusion: Although, as a metabolic disorder, hyperlipidemia is an expected finding
in PCOS; there are conflicting results depending on the evaluated population.
Therefore advanced longitudinal studies are necessary to explain the relationship
between PCOS and lipid levels in our country.

Keywords

HDL cholesterol, LDL cholesterol, hyperlipidemia, Polycystic ovary syndrome

Polikistik Over Sendromlu Kadınların Serum Lipid Konsantrasyonlarının Sağlıklı Kadınlar ile Kıyaslanması- Geriye Yönelik (Retrospektif) İnceleme

Abstract

Bu nedenle biz bu çalışmada PKOS’lu ve ek sağlık
problemi olmayan kadınlar arasındaki lipid parametrelerini kıyaslayarak
incelediğimiz populasyonda hangi parametreler arasında farklılıklar olduğunu ve
bu farklılıkların düzeyini incelemeyi amaçladık.

Yöntem
ve gereçler: 45 PKOS’lu ve 45 sağlıklı kadın yaş ve vücut kitle
indeksi (VKİ) kıyaslamalı olarak retrospektif olarak incelendi. Serum açlık
total kolesterol, yüksek dansiteli lipoprotein (HDL) kolesterol, düşük
dansiteli lipoprotein (LDL) kolesterol, trigliserid, glukoz ve insülin
düzeyleri değerlendirildi.

Bulgular:
Gruplar arasında serum açlık glukoz, total kolesterol, HDL kolesterol, LDL
kolesterol ve insülin konsantrasyonlari arasında anlamlı fark bulunmadı (p>0.05). Serum trigliserid (121,13±42,633
mg/dL ve 94,444±41,809 mg/dL; p=0,004)
ve serum total testosteron konsantrasyonu (46,422±18,551ng/mL ve 36,546±14,365ng/mL;
p=0,006) ise PKOS'lularda anlamlı
olarak daha yüksek saptandı. Lineer regresyon analizinin sonuçlarına göre
sadece trigliserid düzeyleri PKOS ile anlamlı birliktelik gösteriyordu (β=0,262;
p=0,016).

Tartışma
ve sonuç: Bir metabolik bozukluk olarak PKOS’da hiperlipidemi
beklenen bir bulgu olsa da; incelenen populasyonlara bağlı olarak farklı
sonuçlar mevcuttur. Bundan dolayı PKOS’lu kadınlara uygulanacak tedavilerin
uygun planlanması amacı ile ülkemize ait geniş sayıda olguyu içeren longitudinal
çalışmalardan elde edilecek verilere ihtiyaç vardır.

Keywords

HDL kolesterol, LDL kolesterol, Hiperlipidemi, Polikistik over sendromu, Trigliserid

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