BLASTOCYST DEVELOPMENT; DIFFERENCE MECHANİSMS OF CELL LAYERS

Year 2018, Volume: 32 Issue: 3, 243 - 250, 15.12.2018

Funda Yılmaz İşıl Tekmen

Abstract

Zygotes formed after
fertilization undergo successive mitotic divisions, the first three mitosis
divisions are symmetric and morphologically identical 8 blastomeres are formed.
 Important morphological changes occur in
the embryo in 8-cell stage. These are compaction, polarization, and asymmetric
cell division. Following these changes, the primary lineage differentiation in
the cells of the embryo in the 8-32 cell morulae, consist of namely inner cell
mass (ICM) and outer cell mass (Trofoektoderm; TE). Shortly after the ICM,
epiblast (EPI) and primitive endoderm (PE) cell lines differentiate in the
process called secondary progeny differentiation. In this review, the stages of
blastocyst development in the preimplantation period will be elaborated
sequentially and via molecular pathways.

Keywords

Blastocyst, preimplantation, cell lineage

Blastosist gelişimi; hücre soylarının farklanma mekanizmaları

Abstract

Fertilizasyon sonucu oluşan zigot art arda
mitoz bölünmeler geçirir ve ilk 3 mitoz bölünme simetrik olup morfolojik olarak
birbirinin aynısı 8 adet blastomer oluşmaktadır. 8 hücreli aşamada embriyoda
önemli morfolojik değişiklikler meydana gelir. Bunlar; kompaksiyon,
polarizasyon ve asimetrik hücre bölünmesidir. Bu değişikliklerin ardından 8-32
hücreli morula evresinde embriyoda yer alan hücrelerde birincil soy farklanması
yani iç hücre kitlesi (ICM) ve dış hücre kitlesi (Trofoektoderm;TE) hücre
soyları oluşmaktadır. ICM’den kısa bir süre sonra ikincil soy farklanması
denilen epiblast (EPI) ve primitif endoderm (PE) hücre soyları farklanmaktadır.
Bu derlemede; preimplantasyon dönemde blastosist gelişim aşamaları sırasıyla ve
moleküler yolaklar üzerinden ayrıntılandırılacaktır.

Keywords

Blastosist, preimplantasyon, hücre soyları

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