micro RNAs in Ovarian Cancer

Year 2019, Volume: 33 Issue: 1, 93 - 101, 26.04.2019

Hüsnü Töre Yavuzşen Safiye Aktaş Hasan Bhadır Saatli Zekiye Sultan Altun

https://doi.org/10.5505/deutfd.2019.24381

Abstract

Ovarian cancer is the fifth most common cancer death in women. Currently, gynecological examination, evaluation with ultrasound and serum measurements such as CA-125 are the standard for ovarian cancer diagnosis and treatment. However, there is an intense need for new biomarkers that can lead to the diagnosis and treatment of the disease. MicroRNAs (miRNAs), short, protein-coding RNAs, are particularly useful stabilizing endogenous RNAs to become biomarkers in cancer. In this review, it is aimed to investigate the role of miRNAs in ovarian cancer studies conducted to date.

Keywords

Ovarian cancer, microRNA, biomarkers

Over Kanserinde mikro RNA’lar

Abstract

Over kanseri kadınlarda ölümler arasında 5. en sık ölüm nedeni olan kanserdir. Over kanseri tanı ve tedavisi için günümüzde standart olarak jinekolojik muayene, ultarason ile değerlendirme ve CA-125 gibi serum ölçümleri yer almaktadır. Ancak hem hastalığın tanısı ve tedavisi ile yol gösterebilecek yeni biyobelirteçlere yoğun bir ihtiyaç bulunmaktadır. Kısa, protein kodlamayan RNA’lar olan mikroRNA’lar (miRNA), özellikle kanserde biyobelirteç olmak için oldukça kullanışlı stabil endojen RNA’lardır. Bu derleme kapsamında over kanserinde miRNA’ların bugüne dek yapılan çalışmalarda ki rolünün irdelenmesi amaçlanmıştır.

Keywords

Over kanseri, mikroRNA, biyobelirteç

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